Publications by authors named "Richard Lock"

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Polyamine depletion limits progression of acute leukaemia.
Weiman Gao, Mawar Karsa, Lin Xiao, Dayna Spurling, Ayu Karsa, Richard B Lock

Int J Cancer· June 2025

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Immune-deficient MISTRG mice support expansion of leukaemia-initiating cells in xenograft models of paediatric acute myeloid leukaemia.
Patrick Connerty, Jinhan Xie, Fatima El-Najjar, Toby N Trahair, Nisitha Jayatilleke, Richard B Lock

Br J Haematol· April 2025

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Targeting LMO2-induced autocrine FLT3 signaling to overcome chemoresistance in early T-cell precursor acute lymphoblastic leukemia.
Cedric S Tremblay, Jesslyn Saw, Feng Yan, Jacqueline A Boyle, Ovini Amarasinghe, Richard B Lock

Leukemia· March 2025

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Inhibition of the NLRP3 inflammasome using MCC950 reduces vincristine-induced adverse effects in an acute lymphoblastic leukemia patient-derived xenograft model.
Hana Starobova, Hannah McCalmont, Svetlana Shatunova, Nicolette Tay, Christopher M Smith, Richard B Lock

Hemasphere· March 2025

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Targeting osteoclasts for treatment of high-risk B-cell acute lymphoblastic leukemia.
Rishi S Kotecha, Sarah M Trinder, Anastasia M Hughes, Benjamin H Mullin, Sarah Rashid, Richard B Lock

Blood Cancer J· February 2025

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The CD123 antibody-drug conjugate pivekimab sunirine exerts profound activity in preclinical models of pediatric acute lymphoblastic leukemia.
Ben Watts, Christopher M Smith, Kathryn Evans, Andrew J Gifford, Sara M A Mohamed, Richard B Lock

Hemasphere· January 2025

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Lessons learned from 20 years of preclinical testing in pediatric cancers.
Malcolm A Smith, Peter J Houghton, Richard B Lock, John M Maris, Richard Gorlick

Pharmacol Ther· December 2024

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The third generation AKR1C3-activated prodrug, ACHM-025, eradicates disease in preclinical models of aggressive T-cell acute lymphoblastic leukemia.
Cara E Toscan, Hannah McCalmont, Amir Ashoorzadeh, Xiaojing Lin, Zhe Fu, Richard B Lock

Blood Cancer J· November 2024

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PU.1 eviction at lymphocyte-specific chromatin domains mediates glucocorticoid response in acute lymphoblastic leukemia.
Dominik Beck, Honghui Cao, Feng Tian, Yizhou Huang, Miao Jiang, Richard B Lock

Nat Commun· November 2024

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Patient-Specific Circulating Tumor DNA for Monitoring Response to Menin Inhibitor Treatment in Preclinical Models of Infant Leukemia.
Louise Doculara, Kathryn Evans, J Justin Gooding, Narges Bayat, Richard B Lock

Cancers (Basel)· November 2024

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translocation-driven super-enhancer activation leads to eosinophilia in acute lymphoblastic leukemia through IL-3 overexpression.
Wenqian Xu, Feng Tian, Xiaolu Tai, Gaoxian Song, Yuanfang Liu, Richard B Lock

Haematologica· August 2024

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TOPORS E3 ligase mediates resistance to hypomethylating agent cytotoxicity in acute myeloid leukemia cells.
Peter Truong, Sylvie Shen, Swapna Joshi, Md Imtiazul Islam, Ling Zhong, Richard B Lock

Nat Commun· August 2024

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Precision-guided treatment in high-risk pediatric cancers.
Loretta M S Lau, Dong-Anh Khuong-Quang, Chelsea Mayoh, Marie Wong, Paulette Barahona, Richard B Lock

Nat Med· July 2024

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In vivo activity of the second-generation proteasome inhibitor ixazomib against pediatric T-cell acute lymphoblastic leukemia xenografts.
Joanna Randall, Kathryn Evans, Ben Watts, Hansen J Kosasih, Christopher M Smith, Richard B Lock

Exp Hematol· April 2024

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FDA-approved disulfiram as a novel treatment for aggressive leukemia.
Mawar Karsa, Lin Xiao, Emma Ronca, Angelika Bongers, Dayna Spurling, Richard B Lock

J Mol Med (Berl)· April 2024

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An antibody fragment-decorated liposomal conjugate targets Philadelphia-like acute lymphoblastic leukemia.
Sara M A Mohamed, Peter Schofield, Hannah McCalmont, Ernest Moles, Karl-Heinz Friedrich, Richard B Lock

Int J Biol Macromol· January 2024

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The tip of the iceberg-The roles of long noncoding RNAs in acute myeloid leukemia.
Patrick Connerty, Richard B Lock

Wiley Interdiscip Rev RNA· November 2023

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Management of a Large Post-tonsillectomy Thrombus Obstructing the Laryngeal View: A Case Report.
Rana Tamraz, Roman Austin, Ricardo Falcon, Tania Kraai, Richard Lock

Cureus· October 2023

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PLK1 as a cooperating partner for BCL2-mediated antiapoptotic program in leukemia.
Kinjal Shah, Ahmad Nasimian, Mehreen Ahmed, Lina Al Ashiri, Linn Denison, Richard B Lock

Blood Cancer J· September 2023

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In vivo activity of the dual PI3Kδ and PI3Kγ inhibitor duvelisib against pediatric acute lymphoblastic leukemia xenografts.
Joanna Randall, Kathryn Evans, Ben Watts, Christopher M Smith, Keira Hughes, Richard B Lock

Pediatr Blood Cancer· August 2023

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High-Throughput Drug Screening of Primary Tumor Cells Identifies Therapeutic Strategies for Treating Children with High-Risk Cancer.
Chelsea Mayoh, Jie Mao, Jinhan Xie, Gabor Tax, Shu-Oi Chow, Richard B Lock

Cancer Res· August 2023

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STAT5 activation promotes progression and chemotherapy resistance in early T-cell precursor acute lymphoblastic leukemia.
Cedric S Tremblay, Jesslyn Saw, Jacqueline A Boyle, Katharina Haigh, Veronique Litalien, Richard B Lock

Blood· July 2023

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In vivo activity of the dual SYK/FLT3 inhibitor TAK-659 against pediatric acute lymphoblastic leukemia xenografts.
Keira Hughes, Kathryn Evans, Eric J Earley, Christopher M Smith, Stephen W Erickson, Richard B Lock

Pediatr Blood Cancer· June 2023

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Delivery of PEGylated liposomal doxorubicin by bispecific antibodies improves treatment in models of high-risk childhood leukemia.
Ernest Moles, Christopher B Howard, Pie Huda, Mawar Karsa, Hannah McCalmont, Richard B Lock

Sci Transl Med· May 2023

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Blockade of ROS production inhibits oncogenic signaling in acute myeloid leukemia and amplifies response to precision therapies.
Zacary P Germon, Jonathan R Sillar, Abdul Mannan, Ryan J Duchatel, Dilana Staudt, Richard B Lock

Sci Signal· March 2023

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