Publications by authors named "Michael R Botchan"

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Molecular determinants of phase separation for DNA replication licensing factors.
Matthew W Parker, Jonchee A Kao, Alvin Huang, James M Berger, Michael R Botchan

Elife· December 2021

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Structural Mechanisms for Replicating DNA in Eukaryotes.
Ilan Attali, Michael R Botchan, James M Berger

Annu Rev Biochem· June 2021

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Molecular Basis for ATP-Hydrolysis-Driven DNA Translocation by the CMG Helicase of the Eukaryotic Replisome.
Patrik Eickhoff, Hazal B Kose, Fabrizio Martino, Tatjana Petojevic, Ferdos Abid Ali, Michael R Botchan

Cell Rep· September 2019

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A new class of disordered elements controls DNA replication through initiator self-assembly.
Matthew W Parker, Maren Bell, Mustafa Mir, Jonchee A Kao, Xavier Darzacq, Michael R Botchan

Elife· September 2019

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Conformational control and DNA-binding mechanism of the metazoan origin recognition complex.
Franziska Bleichert, Alexander Leitner, Ruedi Aebersold, Michael R Botchan, James M Berger

Proc Natl Acad Sci U S A· June 2018

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Mechanisms and regulation of DNA replication initiation in eukaryotes.
Matthew W Parker, Michael R Botchan, James M Berger

Crit Rev Biochem Mol Biol· April 2017

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Mechanisms for initiating cellular DNA replication.
Franziska Bleichert, Michael R Botchan, James M Berger

Science· February 2017

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Crystal structure of the eukaryotic origin recognition complex.
Franziska Bleichert, Michael R Botchan, James M Berger

Nature· March 2015

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Cdc45 (cell division cycle protein 45) guards the gate of the Eukaryote Replisome helicase stabilizing leading strand engagement.
Tatjana Petojevic, James J Pesavento, Alessandro Costa, Jingdan Liang, Zhijun Wang, Michael R Botchan

Proc Natl Acad Sci U S A· January 2015

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Chromatin reader L(3)mbt requires the Myb-MuvB/DREAM transcriptional regulatory complex for chromosomal recruitment.
Daniel P Blanchard, Daphne Georlette, Lisa Antoszewski, Michael R Botchan

Proc Natl Acad Sci U S A· October 2014

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DNA binding polarity, dimerization, and ATPase ring remodeling in the CMG helicase of the eukaryotic replisome.
Alessandro Costa, Ludovic Renault, Paolo Swuec, Tatjana Petojevic, James J Pesavento, Michael R Botchan

Elife· August 2014

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The minichromosome maintenance replicative helicase.
Stephen D Bell, Michael R Botchan

Cold Spring Harb Perspect Biol· November 2013

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A Meier-Gorlin syndrome mutation in a conserved C-terminal helix of Orc6 impedes origin recognition complex formation.
Franziska Bleichert, Maxim Balasov, Igor Chesnokov, Eva Nogales, Michael R Botchan

Elife· October 2013

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Drosophila lin-52 acts in opposition to repressive components of the Myb-MuvB/dREAM complex.
Peter W Lewis, Debashis Sahoo, Cuiyun Geng, Maren Bell, Joseph S Lipsick, Michael R Botchan

Mol Cell Biol· August 2012

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Checkpoint kinase 2 (Chk2) inhibits the activity of the Cdc45/MCM2-7/GINS (CMG) replicative helicase complex.
Ivar Ilves, Nele Tamberg, Michael R Botchan

Proc Natl Acad Sci U S A· August 2012

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ATP-dependent conformational dynamics underlie the functional asymmetry of the replicative helicase from a minimalist eukaryote.
Artem Y Lyubimov, Alessandro Costa, Franziska Bleichert, Michael R Botchan, James M Berger

Proc Natl Acad Sci U S A· July 2012

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Zelda binding in the early Drosophila melanogaster embryo marks regions subsequently activated at the maternal-to-zygotic transition.
Melissa M Harrison, Xiao-Yong Li, Tommy Kaplan, Michael R Botchan, Michael B Eisen

PLoS Genet· October 2011

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The structural basis for MCM2-7 helicase activation by GINS and Cdc45.
Alessandro Costa, Ivar Ilves, Nele Tamberg, Tatjana Petojevic, Eva Nogales, Michael R Botchan

Nat Struct Mol Biol· April 2011

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Stalled fork rescue via dormant replication origins in unchallenged S phase promotes proper chromosome segregation and tumor suppression.
Tsuyoshi Kawabata, Spencer W Luebben, Satoru Yamaguchi, Ivar Ilves, Ilze Matise, Michael R Botchan

Mol Cell· March 2011

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Grainyhead and Zelda compete for binding to the promoters of the earliest-expressed Drosophila genes.
Melissa M Harrison, Michael R Botchan, Thomas W Cline

Dev Biol· September 2010

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Activation of the MCM2-7 helicase by association with Cdc45 and GINS proteins.
Ivar Ilves, Tatjana Petojevic, James J Pesavento, Michael R Botchan

Mol Cell· January 2010

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Genomic profiling and expression studies reveal both positive and negative activities for the Drosophila Myb MuvB/dREAM complex in proliferating cells.
Daphne Georlette, Soyeon Ahn, David M MacAlpine, Evelyn Cheung, Peter W Lewis, Michael R Botchan

Genes Dev· November 2007

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Discovery of tMAC: a Drosophila testis-specific meiotic arrest complex paralogous to Myb-Muv B.
Eileen L Beall, Peter W Lewis, Maren Bell, Michael Rocha, D Leanne Jones, Michael R Botchan

Genes Dev· April 2007

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Structure of the papillomavirus DNA-tethering complex E2:Brd4 and a peptide that ablates HPV chromosomal association.
Eric A Abbate, Christian Voitenleitner, Michael R Botchan

Mol Cell· December 2006

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Isolation of the Cdc45/Mcm2-7/GINS (CMG) complex, a candidate for the eukaryotic DNA replication fork helicase.
Stephen E Moyer, Peter W Lewis, Michael R Botchan

Proc Natl Acad Sci U S A· July 2006

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