Publications by authors named "Michael Ringel"

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Accelerating activity in the longevity biopharmaceutical sector.
Michael S Ringel, Yue Zhang, Wen Kin Lim

Nat Aging· December 2025

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Why we age.
Michael S Ringel

Biol Rev Camb Philos Soc· December 2025

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Why We Can Thrive past Seventy-Five: In Favor of Efforts to Extend the Human Lifespan.
Carolyn B Ringel, Michael S Ringel, Arthur L Caplan

Hastings Cent Rep· June 2025

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2024 FDA approvals exceed average number but have lower sales projections.
Mathias Baedeker, Michael S Ringel, Clemens C Möller

Nat Rev Drug Discov· February 2025

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Lewy body dementia: Overcoming barriers and identifying solutions.
Kanishka Agarwal, Wendi Backler, Ece Bayram, Leah Bloom, Bradley F Boeve, Michael S Ringel

Alzheimers Dement· March 2024

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2023 FDA approvals: unprecedented volume at moderate value.
Mathias Baedeker, Michael S Ringel, Clemens C Möller

Nat Rev Drug Discov· February 2024

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First-in-class versus best-in-class: an update for new market dynamics.
Lindsay Spring, Kunle Demuren, Michael Ringel, John Wu

Nat Rev Drug Discov· July 2023

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2022 FDA approval number dips: a COVID-19 hangover?
Mathias Baedeker, Michael S Ringel, Clemens C Möller, Ulrik Schulze

Nat Rev Drug Discov· February 2023

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TatA and TatB generate a hydrophobic mismatch important for the function and assembly of the Tat translocon in Escherichia coli.
Denise Mehner-Breitfeld, Michael T Ringel, Daniel Alexander Tichy, Laura J Endter, Kai Steffen Stroh

J Biol Chem· September 2022

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PvdM of fluorescent pseudomonads is required for the oxidation of ferribactin by PvdP in periplasmic pyoverdine maturation.
Michael-Frederick Sugue, Ali Nazmi Burdur, Michael T Ringel, Gerald Dräger, Thomas Brüser

J Biol Chem· August 2022

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2021 FDA approvals: value driven by COVID-19 vaccines.
Mathias Baedeker, Michael S Ringel, Ulrik Schulze

Nat Rev Drug Discov· February 2022

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An unusual overrepresentation of genetic factors related to iron homeostasis in the genome of the fluorescent Pseudomonas sp. ABC1.
Daniel Valenzuela-Heredia, Carlos Henríquez-Castillo, Raúl Donoso, Paris Lavín, Michael T Ringel

Microb Biotechnol· May 2021

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2020 FDA approvals: momentum kept despite COVID-19, but value falls.
Mathias Baedeker, Michael Ringel, Ulrik Schulze

Nat Rev Drug Discov· February 2021

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Breaking Eroom's Law.
Michael S Ringel, Jack W Scannell, Mathias Baedeker, Ulrik Schulze

Nat Rev Drug Discov· December 2020

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Value of 2019 FDA approvals: back to the recent average.
Mathias Baedeker, Michael Ringel, Ulrik Schulze

Nat Rev Drug Discov· February 2020

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Artificial intelligence and machine learning in clinical development: a translational perspective.
Pratik Shah, Francis Kendall, Sean Khozin, Ryan Goosen, Jianying Hu, Michael Ringel

NPJ Digit Med· July 2019

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Innovation in Regulatory Science Is Meeting Evolution of Clinical Evidence Generation.
Myrto Lee, Hoan Ly, Clemens C Möller, Michael S Ringel

Clin Pharmacol Ther· April 2019

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2018 FDA approvals hit all time high - but average value slips again.
Mathias Baedeker, Michael Ringel, Ulrik Schulze

Nat Rev Drug Discov· February 2019

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The biosynthesis of pyoverdines.
Michael T Ringel, Thomas Brüser

Microb Cell· August 2018

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What drives site performance in clinical trials?
Brendan Smith, Linda Martin, Scott Martin, Maria Denslow, Melissa Hutchens, Michael S Ringel

Nat Rev Drug Discov· June 2018

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PvdO is required for the oxidation of dihydropyoverdine as the last step of fluorophore formation in .
Michael T Ringel, Gerald Dräger, Thomas Brüser

J Biol Chem· February 2018

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Market watch: 2017 FDA drug approvals: number rebounds but average value slips.
Mathias Baedeker, Michael Ringel, Valery Panier, Ulrik Schulze

Nat Rev Drug Discov· February 2018

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The periplasmic transaminase PtaA of converts the glutamic acid residue at the pyoverdine fluorophore to α-ketoglutaric acid.
Michael T Ringel, Gerald Dräger, Thomas Brüser

J Biol Chem· November 2017

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What is the right amount to spend on biopharma R&D?
Michael S Ringel

Nat Rev Drug Discov· September 2017

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