Publications by authors named "Michael Riscoe"

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Discovery of Amodiachins, a Novel Class of 4-Aminoquinoline Antimalarials Active against Multidrug-Resistant .
Mason J Handford, Yuexin Li, Teresa Riscoe, Katherine M Liebman, Xiaowei Zhang, Michael K Riscoe

J Med Chem· October 2025

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Structure, assembly and inhibition of the Toxoplasma gondii respiratory chain supercomplex.
Andrew E MacLean, Shikha Shikha, Mariana Ferreira Silva, Max J Gramelspacher, Aaron Nilsen, Michael K Riscoe

Nat Struct Mol Biol· August 2025

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In vivo screen of Plasmodium targets for mosquito-based malaria control.
Alexandra S Probst, Douglas G Paton, Federico Appetecchia, Selina Bopp, Kelsey L Adams, Michael K Riscoe

Nature· July 2025

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Potent Acridone Antimalarial against All Three Life Stages of .
Papireddy Kancharla, Rozalia A Dodean, Yuexin Li, Xiaowei Zhang, Sean Kelly, Michael Riscoe

Res Sq· June 2025

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Development of Next-Generation Antimalarial Acridones with Radical Cure Potential.
Rozalia A Dodean, Yuexin Li, Xiaowei Zhang, Diana Caridha, Michael S Madejczyk, Michael K Riscoe

J Med Chem· April 2025

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Enhanced Anti-Babesia Efficacy of Buparvaquone and Imidocarb When Combined with ELQ-316 In Vitro Culture of .
Natalia M Cardillo, Nicolas F Villarino, Paul A Lacy, Joseph S Doggett, Michael K Riscoe

Pharmaceuticals (Basel)· February 2025

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In artemisinin-resistant falciparum malaria parasites, mitochondrial metabolic pathways are essential for survival but not those of apicoplast.
Manel Ouji, Thibaud Reyser, Yoshiki Yamaryo-Botté, Michel Nguyen, David Rengel, Michael K Riscoe

Int J Parasitol Drugs Drug Resist· December 2024

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The Combination of Buparvaquone and ELQ316 Exhibit a Stronger Effect than ELQ316 and Imidocarb Against In Vitro.
Natalia M Cardillo, Nicolas F Villarino, Paul A Lacy, Michael K Riscoe, Joseph Stone Doggett

Pharmaceutics· October 2024

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Robenidine derivatives as potential antischistosomal drug candidates.
Christian N Lotz, Alina Krollenbrock, Lea Imhof, Michael Riscoe, Jennifer Keiser

Int J Parasitol Drugs Drug Resist· August 2024

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Long-acting intramuscular injections of ELQ-331, an antimalarial agent.
Dipu Karunakaran, Shravan K Mutyam, Melody Fu, Jiaming Chen, Kim Hue Nicky Pham, Michael K Riscoe

Eur J Pharm Sci· July 2024

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3-Position Biaryl Endochin-like Quinolones with Enhanced Antimalarial Performance.
Sovitj Pou, Rolf W Winter, Rozalia A Dodean, Katherine Liebman, Yuexin Li, Teresa M Riscoe, Michael K Riscoe

ACS Infect Dis· July 2024

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Synthesis of Deuterated Endochin-Like Quinolones.
Sovitj Pou, Rolf W Winter, Katherine M Liebman, Rosie A Dodean, Aaron Nilsen, Michael K Riscoe

J Labelled Comp Radiopharm· May 2024

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Comparative efficacy of buparvaquone and imidocarb in inhibiting the growth of .
Natalia M Cardillo, Paul A Lacy, Nicolas F Villarino, J Stone Doggett, Michael K Riscoe

Front Pharmacol· May 2024

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Effectiveness of Two New Endochin-like Quinolones, ELQ-596 and ELQ-650, in Experimental Mouse Models of Human Babesiosis.
Pratap Vydyam, Meenal Chand, Sovitj Pou, Rolf W Winter, Katherine M Liebman, Michael K Riscoe

ACS Infect Dis· April 2024

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2-hydroxy-1,4-naphthoquinones with 3-alkyldiarylether groups: synthesis and inhibitory activity.
Amanda Berg, Chelsea B Swartchick, Noah Forrest, Matthew Chavarria, Madeleine C Deem, Teresa M Riscoe, Michael K Riscoe

Future Med Chem· November 2022

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Babesia duncani as a Model Organism to Study the Development, Virulence, and Drug Susceptibility of Intraerythrocytic Parasites In Vitro and In Vivo.
Anasuya C Pal, Isaline Renard, Pallavi Singh, Pratap Vydyam, Joy E Chiu, Michael K Riscoe

J Infect Dis· September 2022

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Cytochrome b Drug Resistance Mutation Decreases Babesia Fitness in the Tick Stages But Not the Mammalian Erythrocytic Cycle.
Joy E Chiu, Isaline Renard, Santosh George, Anasuya C Pal, P Holland Alday, Michael K Riscoe

J Infect Dis· January 2022

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Effective Therapy Targeting Cytochrome Prevents Erythrocytic Development and Protects from Lethal Infection.
Joy E Chiu, Isaline Renard, Anasuya C Pal, Pallavi Singh, Pratap Vydyam, Michael K Riscoe

Antimicrob Agents Chemother· August 2021

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A New Scalable Synthesis of ELQ-300, ELQ-316, and other Antiparasitic Quinolones.
Sovitj Pou, Rozalia A Dodean, Lisa Frueh, Katherine M Liebman, Rory T Gallagher, Michael K Riscoe

Org Process Res Dev· August 2021

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Robenidine Analogues Are Potent Antimalarials in Drug-Resistant .
Alina Krollenbrock, Yuexin Li, Jane Xu Kelly, Michael K Riscoe

ACS Infect Dis· July 2021

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Atypical Molecular Basis for Drug Resistance to Mitochondrial Function Inhibitors in Plasmodium falciparum.
Heather J Painter, Joanne M Morrisey, Michael W Mather, Lindsey M Orchard, Cuyler Luck, Michael K Riscoe

Antimicrob Agents Chemother· February 2021

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Endochin-like quinolone-300 and ELQ-316 inhibit Babesia bovis, B. bigemina, B. caballi and Theileria equi.
Marta G Silva, Reginaldo G Bastos, J Stone Doggett, Michael K Riscoe, Sovitj Pou

Parasit Vectors· December 2020

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Orally Bioavailable Endochin-Like Quinolone Carbonate Ester Prodrug Reduces Toxoplasma gondii Brain Cysts.
J Stone Doggett, Tracey Schultz, Alyssa J Miller, Igor Bruzual, Sovitj Pou, Michael K Riscoe

Antimicrob Agents Chemother· August 2020

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Lead Optimization of Second-Generation Acridones as Broad-Spectrum Antimalarials.
Papireddy Kancharla, Rozalia A Dodean, Yuexin Li, Sovitj Pou, Brandon Pybus, Michael K Riscoe

J Med Chem· June 2020

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Genetic ablation of the mitoribosome in the malaria parasite sensitizes it to antimalarials that target mitochondrial functions.
Liqin Ling, Maruthi Mulaka, Justin Munro, Swati Dass, Michael W Mather, Michael K Riscoe

J Biol Chem· May 2020

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