Publications by authors named "Michael Spohn"

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Investigation of a global mouse methylome atlas reveals subtype-specific copy number alterations in pediatric cancer models.
Melanie Schoof, Tuyu Zheng, Martin Sill, Roland Imle, Alessia Cais, Michael Spohn

Nat Genet· December 2025

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Characterization of a PRKCE::ETV6 fusion as a potential oncogenic driver in T-cell acute lymphoblastic leukemia.
Esther L Monsees, Udo Zur Stadt, Julia Strauss, Sabrina Schuster, Nadja Kleist, Michael Spohn

Mol Cell Pediatr· October 2025

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Defective proviruses cause T cell reprogramming through promoter exaptation in HIV-1 infection.
Martin V Hamann, Lisa Brauckmann, Christoph Schwarz, Michael Spohn, Ramon Stoeck

bioRxiv· September 2025

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A case report of a pediatric T-cell acute lymphoblastic leukemia with a subclonal t(2;5) translocation - implementation for the selection of MRD-targets.
Esther L Monsees, Richard T Hauch, Antonina Wrzeszcz, Michael Spohn, Julia Strauss

Leuk Lymphoma· August 2025

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Interferon Regulatory Factor 4 dose-dependently controls peripheral Treg cell differentiation and homeostasis by modulating chromatin accessibility in mice.
Leonie Caroline Voß, Constantin Schmidt, Aenne Harberts, Michael Spohn, Peter Bradtke

Front Immunol· July 2025

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Memory-like Natural Killer Cell and CD19 Antibody-Based Immunotherapy in Combination with Tyrosine Kinase Inhibition Has Antitumor Effects against Ph(-like) Acute Lymphoblastic Leukemia.
Zoya Eskandarian, Richard Hauch, Sabrina Schuster, Dorothee Winterberg, Hjördis Grabellus, Michael Spohn

Cancer Immunol Res· June 2025

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MVA-based SARS-CoV-2 vaccine candidates encoding different spike protein conformations induce distinct early transcriptional responses which may impact subsequent adaptive immunity.
Ilka Grewe, Monika Friedrich, Marie-Louise Dieck, Michael Spohn, My Linh Ly

Front Immunol· January 2025

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Genetic Risk Profiling Reveals Altered Glycosyltransferase Expression as a Predictor for Patient Outcome in Neuroblastoma.
Isabelle Ariane Bley, Stefan Behrens, Michael Spohn, Ingo Müller, Benjamin Schattling

J Clin Med· January 2025

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Functional screening reveals genetic dependencies and diverging cell cycle control in atypical teratoid rhabdoid tumors.
Daniel J Merk, Foteini Tsiami, Sophie Hirsch, Bianca Walter, Lara A Haeusser, Michael Spohn

Genome Biol· December 2024

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Transcriptomics-based characterization of the immuno-stromal microenvironment in pediatric low-grade glioma.
Meik Körner, Michael Spohn, Ulrich Schüller, Michael Bockmayr

Oncoimmunology· August 2024

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Diagnostic leukapheresis reveals distinct phenotypes of NSCLC circulating tumor cells.
Lisa-Marie Rieckmann, Michael Spohn, Lisa Ruff, David Agorku, Lisa Becker

Mol Cancer· May 2024

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CD301 and LSECtin glycan-binding receptors of innate immune cells serve as prognostic markers and potential predictors of immune response in breast cancer subtypes.
Anne-Sophie Wegscheider, Irina Wojahn, Pablo Gottheil, Michael Spohn, Joseph Alfons Käs

Glycobiology· April 2024

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SMARCA4 Loss and Mutated β-Catenin Induce Proliferative Lesions in the Murine Embryonic Cerebellum.
Carolin Göbel, Melanie Schoof, Dörthe Holdhof, Michael Spohn, Ulrich Schüller

J Neurosci· April 2024

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Expression of full-length FOXP3 exceeds other isoforms in thymus and stimulated CD4 + T cells.
Benita Kröger, Michael Spohn, Marion Mengel, Jan-Peter Sperhake, Benjamin Ondruschka

J Clin Immunol· April 2024

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Mouse models of pediatric high-grade gliomas with MYCN amplification reveal intratumoral heterogeneity and lineage signatures.
Melanie Schoof, Shweta Godbole, Thomas K Albert, Matthias Dottermusch, Carolin Walter, Michael Spohn

Nat Commun· November 2023

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Risk prediction in early childhood sonic hedgehog medulloblastoma treated with radiation-avoiding chemotherapy: Evidence for more than 2 subgroups.
Svenja Tonn, Andrey Korshunov, Denise Obrecht, Martin Sill, Michael Spohn

Neuro Oncol· August 2023

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IRF4 is required for migration of CD4 T cells to the intestine but not for Th2 and Th17 cell maintenance.
Constantin Schmidt, Aenne Harberts, Daniel Reimers, Tabea Bertram, Leonie Caroline Voß, Michael Spohn

Front Immunol· July 2023

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Early-life exposure to tobacco smoke alters airway signaling pathways and later mortality in D. melanogaster.
Karolina-Theresa Sirocko, Hanna Angstmann, Stephanie Papenmeier, Christina Wagner, Michael Spohn

Environ Pollut· September 2022

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Disease modeling of a mutation in α-actinin 2 guides clinical therapy in hypertrophic cardiomyopathy.
Maksymilian Prondzynski, Marc D Lemoine, Antonia Tl Zech, András Horváth, Vittoria Di Mauro, Michael Spohn

EMBO Mol Med· August 2022

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Persistence of MERS-CoV-spike-specific B cells and antibodies after late third immunization with the MVA-MERS-S vaccine.
Leonie M Weskamm, Anahita Fathi, Matthijs P Raadsen, Anna Z Mykytyn, Till Koch, Michael Spohn

Cell Rep Med· July 2022

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Clofarabine increases the eradication of minimal residual disease of primary B-precursor acute lymphoblastic leukemia compared to high-dose cytarabine without improvement of outcome. Results from the randomized clinical trial 08-09 of the Cooperative Acute Lymphoblastic Leukemia Study Group.
Gabriele Escherich, Udo Zur Stadt, Arndt Borkhardt, Dagmar Dilloo, Jörg Faber, Michael Spohn

Haematologica· May 2022

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Clinical and molecular characterization of isolated M1 disease in pediatric medulloblastoma: experience from the German HIT-MED studies.
Denise Obrecht, Martin Mynarek, Christian Hagel, Robert Kwiecien, Michael Spohn

J Neurooncol· March 2022

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Primary central nervous system sarcoma with DICER1 mutation-treatment results of a novel molecular entity in pediatric Peruvian patients.
Rosdali Y Diaz Coronado, Martin Mynarek, Christian Koelsche, Pamela Mora Alferez, Sandro Casavilca Zambrano, Michael Spohn

Cancer· February 2022

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Generation of hiPSC-derived low threshold mechanoreceptors containing axonal termini resembling bulbous sensory nerve endings and expressing Piezo1 and Piezo2.
Shuyong Zhu, Nancy Stanslowsky, Jorge Fernández-Trillo, Tamrat M Mamo, Pengfei Yu, Michael Spohn

Stem Cell Res· October 2021

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Brahma-related gene 1 has time-specific roles during brain and eye development.
Dörthe Holdhof, Melanie Schoof, Sina Al-Kershi, Michael Spohn, Catena Kresbach

Development· May 2021

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