Publications by authors named "Michael Toft Overgaard"

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Functional consequences of calmodulin variants identified among schizophrenia patients and controls.
Helene Halkjær Jensen, Malene Brohus, John W Hussey, Ana-Octavia Busuioc, Emil Drivsholm Iversen, Michael Toft Overgaard

Transl Psychiatry· November 2025

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To Fly, or Not to Fly, That Is the Question: A Deep Learning Model for Peptide Detectability Prediction in Mass Spectrometry.
Naim Abdul-Khalek, Mario Picciani, Omar Shouman, Reinhard Wimmer, Michael Toft Overgaard

J Proteome Res· June 2025

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Inositol 1,4,5-Trisphosphate Receptor 1 Gain-of-Function Increases the Risk for Cardiac Arrhythmias in Mice and Humans.
Bo Sun, Mingke Ni, Yanhui Li, Zhenpeng Song, Hui Wang, Michael Toft Overgaard

Circulation· March 2025

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A homo-FRET assay for patatin-specific proteolytic activity.
Lise Friis Christensen, Michael Toft Overgaard, Egon Bech Hansen, Simon Gregersen Echers

Food Chem· January 2025

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Role of Calmodulin in Cardiac Disease: Insights on Genotype and Phenotype.
Peter J Schwartz, Lia Crotti, Mette Nyegaard, Michael Toft Overgaard

Circ Genom Precis Med· October 2024

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Decoding the impact of neighboring amino acids on ESI-MS intensity output through deep learning.
Naim Abdul-Khalek, Reinhard Wimmer, Michael Toft Overgaard, Simon Gregersen Echers

J Proteomics· October 2024

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Calmodulin, sudden death, and the Folbigg case: genes in court.
Peter J Schwartz, Lia Crotti, Mette Nyegaard, Michael Toft Overgaard

Eur Heart J· May 2024

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Allosteric changes in protein stability and dynamics as pathogenic mechanism for calmodulin variants not affecting Ca coordinating residues.
Christina Vallentin Holler, Nina Møller Petersson, Malene Brohus, Miska Aleksanteri Niemelä, Emil Drivsholm Iversen, Michael Toft Overgaard

Cell Calcium· January 2024

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Calmodulin mutations affecting Gly114 impair binding to the Na1.5 IQ-domain.
Malene Brohus, Ana-Octavia Busuioc, Reinhard Wimmer, Mette Nyegaard, Michael Toft Overgaard

Front Pharmacol· August 2023

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Insight on physicochemical properties governing peptide MS1 response in HPLC-ESI-MS/MS: A deep learning approach.
Naim Abdul-Khalek, Reinhard Wimmer, Michael Toft Overgaard, Simon Gregersen Echers

Comput Struct Biotechnol J· July 2023

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Polygenic Risk Score Prediction for Endometriosis.
Kirstine Kloeve-Mogensen, Palle Duun Rohde, Simone Twisttmann, Marianne Nygaard, Kristina Magaard Koldby, Michael Toft Overgaard

Front Reprod Health· December 2021

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Infanticide vs. inherited cardiac arrhythmias.
Malene Brohus, Todor Arsov, David A Wallace, Helene Halkjær Jensen, Mette Nyegaard, Michael Toft Overgaard

Europace· March 2021

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AnOxPePred: using deep learning for the prediction of antioxidative properties of peptides.
Tobias Hegelund Olsen, Betül Yesiltas, Frederikke Isa Marin, Margarita Pertseva, Pedro J García-Moreno, Michael Toft Overgaard

Sci Rep· December 2020

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Biofunctionality of Enzymatically Derived Peptides from Codfish () Frame: Bulk In Vitro Properties, Quantitative Proteomics, and Bioinformatic Prediction.
Ali Jafarpour, Simon Gregersen, Rocio Marciel Gomes, Paolo Marcatili, Tobias Hegelund Olsen, Michael Toft Overgaard

Mar Drugs· November 2020

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The arrhythmogenic N53I variant subtly changes the structure and dynamics in the calmodulin N-terminal domain, altering its interaction with the cardiac ryanodine receptor.
Christian Holt, Louise Hamborg, Kelvin Lau, Malene Brohus, Anders Bundgaard Sørensen, Michael Toft Overgaard

J Biol Chem· May 2020

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Arrhythmia mutations in calmodulin can disrupt cooperativity of Ca binding and cause misfolding.
Kaiqian Wang, Malene Brohus, Christian Holt, Michael Toft Overgaard, Reinhard Wimmer

J Physiol· March 2020

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Beating tissue factor at its own game: Design and properties of a soluble tissue factor-independent coagulation factor VIIa.
Anders B Sorensen, Inga Tuneew, L Anders Svensson, Egon Persson, Henrik Østergaard, Michael Toft Overgaard

J Biol Chem· January 2020

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Therapeutic endometrial scratching and implantation after in vitro fertilization: a multicenter randomized controlled trial.
Mia Steengaard Olesen, Benedicte Hauge, Lisbeth Ohrt, Tine Nørregaard Olesen, Janne Roskær, Michael Toft Overgaard

Fertil Steril· December 2019

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Dissection of the antimicrobial and hemolytic activity of Cap18: Generation of Cap18 derivatives with enhanced specificity.
Anna Ebbensgaard, Hanne Mordhorst, Michael Toft Overgaard, Frank Møller Aarestrup, Egon Bech Hansen

PLoS One· December 2018

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Arrhythmia mutations in calmodulin cause conformational changes that affect interactions with the cardiac voltage-gated calcium channel.
Kaiqian Wang, Christian Holt, Jocelyn Lu, Malene Brohus, Kamilla Taunsig Larsen, Michael Toft Overgaard

Proc Natl Acad Sci U S A· November 2018

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Monoclonal antibodies targeting the disintegrin-like domain of ADAMDEC1 modulates the proteolytic activity and enables quantification of ADAMDEC1 protein in human plasma.
Jacob Lund, Anne Mette Elimar Bitsch, Morten Grønbech Rasch, Mari Enoksson, Linda Troeberg, Michael Toft Overgaard

MAbs· January 2018

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The Arrhythmogenic Calmodulin p.Phe142Leu Mutation Impairs C-domain Ca2+ Binding but Not Calmodulin-dependent Inhibition of the Cardiac Ryanodine Receptor.
Mads Toft Søndergaard, Yingjie Liu, Kamilla Taunsig Larsen, Alma Nani, Xixi Tian, Michael Toft Overgaard

J Biol Chem· January 2017

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Biochemical Foundations of Health and Energy Conservation in Hibernating Free-ranging Subadult Brown Bear Ursus arctos.
Karen Gjesing Welinder, Rasmus Hansen, Michael Toft Overgaard, Malene Brohus, Mads Sønderkær

J Biol Chem· October 2016

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Comparative Evaluation of the Antimicrobial Activity of Different Antimicrobial Peptides against a Range of Pathogenic Bacteria.
Anna Ebbensgaard, Hanne Mordhorst, Michael Toft Overgaard, Claus Gyrup Nielsen, Frank Møller Aarestrup

PLoS One· June 2016

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Participation of mitogen-activated protein kinase in luteinizing hormone-induced differential regulation of steroidogenesis and steroidogenic gene expression in mural and cumulus granulosa cells of mouse preovulatory follicles.
You-Qiang Su, Mette Nyegaard, Michael Toft Overgaard, Jie Qiao, Linda C Giudice

Biol Reprod· December 2006

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