Publications by authors named "Michael Witcher"

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Assessing radiosensitivity through sublethal damage recovery: a comparison of survival-based and molecular repair kinetics.
Naim Chabaytah, Mirta Dumančić, Emmanuel C Asante, Tanner Connell, Michael Witcher

Phys Med Biol· June 2025

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Combined Inhibition of MNK Signaling and BET Proteins Reveals TGM2 as a Novel Vulnerability in Melanoma.
Antoine Méant, Omar Moussa, Benjamin Lebeau, Christophe Gonçalves, Vincent R Richard, Michael Witcher

J Invest Dermatol· April 2025

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The Neurodevelopmental Protein POGZ Suppresses Metastasis in Triple-Negative Breast Cancer by Attenuating TGFβ Signaling.
John Heath, Caitlynn Mirabelli, Matthew G Annis, Valerie Sabourin, Steven Hebert, Michael Witcher

Cancer Res· November 2024

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MTOR modulation induces selective perturbations in histone methylation which influence the anti-proliferative effects of mTOR inhibitors.
HaEun Kim, Benjamin Lebeau, David Papadopoli, Predrag Jovanovic, Mariana Russo, Michael Witcher

iScience· March 2024

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3D chromatin remodeling potentiates transcriptional programs driving cell invasion.
Benjamin Lebeau, Maïka Jangal, Tiejun Zhao, Cheng Kit Wong, Nolan Wong, Michael Witcher

Proc Natl Acad Sci U S A· September 2022

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Single base-pair resolution analysis of DNA binding motif with MoMotif reveals an oncogenic function of CTCF zinc-finger 1 mutation.
Benjamin Lebeau, Kaiqiong Zhao, Maika Jangal, Tiejun Zhao, Maria Guerra, Michael Witcher

Nucleic Acids Res· August 2022

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POGZ promotes homology-directed DNA repair in an HP1-dependent manner.
John Heath, Estelle Simo Cheyou, Steven Findlay, Vincent M Luo, Edgar Pinedo Carpio, Michael Witcher

EMBO Rep· January 2022

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STAT1 potentiates oxidative stress revealing a targetable vulnerability that increases phenformin efficacy in breast cancer.
Stephanie P Totten, Young Kyuen Im, Eduardo Cepeda Cañedo, Ouafa Najyb, Alice Nguyen, Michael Witcher

Nat Commun· June 2021

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Achieving clinical success with BET inhibitors as anti-cancer agents.
Tatiana Shorstova, William D Foulkes, Michael Witcher

Br J Cancer· April 2021

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Glioblastoma cell populations with distinct oncogenic programs release podoplanin as procoagulant extracellular vesicles.
Nadim Tawil, Rayhaan Bassawon, Brian Meehan, Ali Nehme, Laura Montermini, Michael Witcher

Blood Adv· March 2021

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p66ShcA potentiates the cytotoxic response of triple-negative breast cancers to PARP inhibitors.
Eduardo Cepeda Cañedo, Stephanie Totten, Ryuhjin Ahn, Paul Savage, Deanna MacNeil, Michael Witcher

JCI Insight· February 2021

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Reprogramming of Nucleotide Metabolism Mediates Synergy between Epigenetic Therapy and MAP Kinase Inhibition.
Tatiana Shorstova, Jie Su, Tiejun Zhao, Michael Dahabieh, Matthew Leibovitch, Michael Witcher

Mol Cancer Ther· January 2021

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Antitumor activity of the dual BET and CBP/EP300 inhibitor NEO2734.
Filippo Spriano, Eugenio Gaudio, Luciano Cascione, Chiara Tarantelli, Federica Melle, Michael Witcher

Blood Adv· September 2020

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Small-Cell Carcinoma of the Ovary, Hypercalcemic Type-Genetics, New Treatment Targets, and Current Management Guidelines.
Marc Tischkowitz, Sidong Huang, Susana Banerjee, Jennifer Hague, William P D Hendricks, Michael Witcher

Clin Cancer Res· August 2020

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Methionine Metabolism Shapes T Helper Cell Responses through Regulation of Epigenetic Reprogramming.
Dominic G Roy, Jocelyn Chen, Victoria Mamane, Eric H Ma, Brejnev M Muhire, Michael Witcher

Cell Metab· February 2020

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Beyond EZH2: is the polycomb protein CBX2 an emerging target for anti-cancer therapy?
Maïka Jangal, Benjamin Lebeau, Michael Witcher

Expert Opin Ther Targets· July 2019

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SWI/SNF-Compromised Cancers Are Susceptible to Bromodomain Inhibitors.
Tatiana Shorstova, Maud Marques, Jie Su, Jake Johnston, Claudia L Kleinman, Michael Witcher

Cancer Res· May 2019

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MNK1/NODAL Signaling Promotes Invasive Progression of Breast Ductal Carcinoma .
Qianyu Guo, Vivian Z Li, Jessica N Nichol, Fan Huang, William Yang, Michael Witcher

Cancer Res· April 2019

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Oncogenic activity of poly (ADP-ribose) glycohydrolase.
Maud Marques, Maika Jangal, Li-Chun Wang, Anna Kazanets, Sabrina Daniela da Silva, Michael Witcher

Oncogene· March 2019

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CDK4/6 inhibitors target SMARCA4-determined cyclin D1 deficiency in hypercalcemic small cell carcinoma of the ovary.
Yibo Xue, Brian Meehan, Elizabeth Macdonald, Sriram Venneti, Xue Qing D Wang, Michael Witcher

Nat Commun· February 2019

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HIV-1 Employs Multiple Mechanisms To Resist Cas9/Single Guide RNA Targeting the Viral Primer Binding Site.
Zhen Wang, Wenzhou Wang, Ya Cheng Cui, Qinghua Pan, Weijun Zhu, Michael Witcher

J Virol· October 2018

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Peroxisomes and cancer: The role of a metabolic specialist in a disease of aberrant metabolism.
Michael S Dahabieh, Erminia Di Pietro, Maïka Jangal, Christophe Goncalves, Michael Witcher

Biochim Biophys Acta Rev Cancer· August 2018

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Competition between translation initiation factor eIF5 and its mimic protein 5MP determines non-AUG initiation rate genome-wide.
Leiming Tang, Jacob Morris, Ji Wan, Chelsea Moore, Yoshihiko Fujita, Michael Witcher

Nucleic Acids Res· November 2017

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CTCF facilitates DNA double-strand break repair by enhancing homologous recombination repair.
Khalid Hilmi, Maïka Jangal, Maud Marques, Tiejun Zhao, Amine Saad, Michael Witcher

Sci Adv· May 2017

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Insights into a novel nuclear function for Fascin in the regulation of the amino-acid transporter SLC3A2.
Amine Saad, Krikor Bijian, Dinghong Qiu, Sabrina Daniela da Silva, Maud Marques, Michael Witcher

Sci Rep· November 2016

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