Publications by authors named "Michal Stark"

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Folylpolyglutamate synthetase mRNA G-quadruplexes regulate its cell protrusion localization and enhance a cancer cell invasive phenotype upon folate repletion.
Michal Stark, May Levin, Igor Ulitsky, Yehuda G Assaraf

BMC Biol· February 2023

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Doubly Stimulated Corrole for Organelle-Selective Antitumor Cytotoxicity.
Vinay K Sharma, Michal Stark, Natalia Fridman, Yehuda G Assaraf, Zeev Gross

J Med Chem· April 2022

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Folylpoly-ɣ-glutamate synthetase association to the cytoskeleton: Implications to folate metabolon compartmentalization.
Michal Stark, Shachar Raz, Yehuda G Assaraf

J Proteomics· May 2021

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Deciphering molecular mechanisms underlying chemoresistance in relapsed AML patients: towards precision medicine overcoming drug resistance.
May Levin, Michal Stark, Yishai Ofran, Yehuda G Assaraf

Cancer Cell Int· January 2021

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The Lysosomotropic Activity of Hydrophobic Weak Base Drugs is Mediated via Their Intercalation into the Lysosomal Membrane.
Michal Stark, Tomás F D Silva, Guy Levin, Miguel Machuqueiro, Yehuda G Assaraf

Cells· April 2020

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Surmounting Cytarabine-resistance in acute myeloblastic leukemia cells and specimens with a synergistic combination of hydroxyurea and azidothymidine.
May Levin, Michal Stark, Bluma Berman, Yehuda G Assaraf

Cell Death Dis· May 2019

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Lysosomotropic drugs activate TFEB via lysosomal membrane fluidization and consequent inhibition of mTORC1 activity.
Benny Zhitomirsky, Anna Yunaev, Roman Kreiserman, Ariel Kaplan, Michal Stark

Cell Death Dis· December 2018

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The JmjN domain as a dimerization interface and a targeted inhibitor of KDM4 demethylase activity.
May Levin, Michal Stark, Yehuda G Assaraf

Oncotarget· March 2018

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Structural recognition of tubulysin B derivatives by multidrug resistance efflux transporters in human cancer cells.
Michal Stark, Yehuda G Assaraf

Oncotarget· July 2017

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Folylpoly-γ-glutamate synthetase: A key determinant of folate homeostasis and antifolate resistance in cancer.
Shachar Raz, Michal Stark, Yehuda G Assaraf

Drug Resist Updat· September 2016

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Folylpolyglutamate synthetase splicing alterations in acute lymphoblastic leukemia are provoked by methotrexate and other chemotherapeutics and mediate chemoresistance.
Anna Wojtuszkiewicz, Shachar Raz, Michal Stark, Yehuda G Assaraf, Gerrit Jansen

Int J Cancer· April 2016

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Binding of a Smad4/Ets-1 complex to a novel intragenic regulatory element in exon12 of FPGS underlies decreased gene expression and antifolate resistance in leukemia.
Shachar Raz, Michal Stark, Yehuda G Assaraf

Oncotarget· October 2014

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Multiple MAPK cascades regulate the transcription of IME1, the master transcriptional activator of meiosis in Saccharomyces cerevisiae.
Smadar Kahana-Edwin, Michal Stark, Yona Kassir

PLoS One· September 2014

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The roles of the catalytic and noncatalytic activities of Rpd3L and Rpd3S in the regulation of gene transcription in yeast.
Daniella Yeheskely-Hayon, Anat Kotler, Michal Stark, Tamar Hashimshony, Shira Sagee

PLoS One· September 2014

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Heterogeneous nuclear ribonucleoprotein H1/H2-dependent unsplicing of thymidine phosphorylase results in anticancer drug resistance.
Michal Stark, Eran E Bram, Martin Akerman, Yael Mandel-Gutfreund, Yehuda G Assaraf

J Biol Chem· February 2011

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Arabinogalactan-folic acid-drug conjugate for targeted delivery and target-activated release of anticancer drugs to folate receptor-overexpressing cells.
Roy I Pinhassi, Yehuda G Assaraf, Shimon Farber, Michal Stark, Diana Ickowicz

Biomacromolecules· January 2010

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Chemotherapeutic drug-induced ABCG2 promoter demethylation as a novel mechanism of acquired multidrug resistance.
Eran E Bram, Michal Stark, Shachar Raz, Yehuda G Assaraf

Neoplasia· December 2009

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Functional elements in the minimal promoter of the human proton-coupled folate transporter.
Michal Stark, Nitzan Gonen, Yehuda G Assaraf

Biochem Biophys Res Commun· October 2009

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Aberrant splicing of folylpolyglutamate synthetase as a novel mechanism of antifolate resistance in leukemia.
Michal Stark, Chen Wichman, Irit Avivi, Yehuda G Assaraf

Blood· April 2009

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Sex-specific differences in peripheral microvascular blood flow in preterm infants.
Michal J Stark, Vicki L Clifton, Ian M R Wright

Pediatr Res· April 2008

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Loss of Sp1 function via inhibitory phosphorylation in antifolate-resistant human leukemia cells with down-regulation of the reduced folate carrier.
Michal Stark, Yehuda G Assaraf

Blood· January 2006

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The reduced folate carrier gene is a novel selectable marker for recombinant protein overexpression.
Lilah Rothem, Bluma Berman, Michal Stark, Gerrit Jansen, Yehuda G Assaraf

Mol Pharmacol· September 2005

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Disparate mechanisms of antifolate resistance provoked by methotrexate and its metabolite 7-hydroxymethotrexate in leukemia cells: implications for efficacy of methotrexate therapy.
Kambiz Fotoohi, Gerrit Jansen, Yehuda G Assaraf, Lilah Rothem, Michal Stark

Blood· December 2004

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Impaired CREB-1 phosphorylation in antifolate-resistant cell lines with down-regulation of the reduced folate carrier gene.
Lilah Rothem, Michal Stark, Yehuda G Assaraf

Mol Pharmacol· December 2004

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Targeting an extracellular epitope of the human multidrug resistance protein 1 (MRP1) in malignant cells with a novel recombinant single chain Fv antibody.
Liat Binyamin, Yehuda G Assaraf, Maya Haus-Cohen, Michal Stark, Yoram Reiter

Int J Cancer· July 2004

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