Publications by authors named "Mihir D Parikh"

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Peptidylarginine Deiminase (PAD) Inhibitor Optimization through Displacement of a Trapped Water Molecule.
Mark E Schnute, Gary M Chinigo, Kentaro Futatsugi, Masaya Yamaguchi, Scott W Bagley, Mihir D Parikh

ACS Med Chem Lett· August 2025

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PF-07059013: A Noncovalent Modulator of Hemoglobin for Treatment of Sickle Cell Disease.
Ariamala Gopalsamy, Ann E Aulabaugh, Amey Barakat, Kevin C Beaumont, Shawn Cabral, Mihir D Parikh

J Med Chem· January 2021

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Selective, Small-Molecule Co-Factor Binding Site Inhibition of a Su(var)3-9, Enhancer of Zeste, Trithorax Domain Containing Lysine Methyltransferase.
Alexandria P Taylor, Magdalena Swewczyk, Steven Kennedy, Viacheslav V Trush, Hong Wu, Mihir D Parikh

J Med Chem· September 2019

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Aminopyrazole Carboxamide Bruton's Tyrosine Kinase Inhibitors. Irreversible to Reversible Covalent Reactive Group Tuning.
Mark E Schnute, Stephen E Benoit, Ingrid P Buchler, Nicole Caspers, Margaret L Grapperhaus, Mihir D Parikh

ACS Med Chem Lett· January 2019

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Identification of N-{cis-3-[Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide (PF-04965842): A Selective JAK1 Clinical Candidate for the Treatment of Autoimmune Diseases.
Michael L Vazquez, Neelu Kaila, Joseph W Strohbach, John D Trzupek, Matthew F Brown, Mihir D Parikh

J Med Chem· February 2018

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Design of Potent mRNA Decapping Scavenger Enzyme (DcpS) Inhibitors with Improved Physicochemical Properties To Investigate the Mechanism of Therapeutic Benefit in Spinal Muscular Atrophy (SMA).
Ariamala Gopalsamy, Arjun Narayanan, Shenping Liu, Mihir D Parikh, Robert E Kyne

J Med Chem· April 2017

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Chemoselective Preparation of Clickable Aryl Sulfonyl Fluoride Monomers: A Toolbox of Highly Functionalized Intermediates for Chemical Biology Probe Synthesis.
Olugbeminiyi Fadeyi, Mihir D Parikh, Ming Z Chen, Robert E Kyne, Alexandria P Taylor

Chembiochem· October 2016

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A library approach to rapidly discover photoaffinity probes of the mRNA decapping scavenger enzyme DcpS.
Hua Xu, Erik C Hett, Ariamala Gopalsamy, Mihir D Parikh, Kieran F Geoghegan

Mol Biosyst· October 2015

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Rational targeting of active-site tyrosine residues using sulfonyl fluoride probes.
Erik C Hett, Hua Xu, Kieran F Geoghegan, Ariamala Gopalsamy, Robert E Kyne, Mihir D Parikh

ACS Chem Biol· April 2015

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Selectively targeting an inactive conformation of interleukin-2-inducible T-cell kinase by allosteric inhibitors.
Seungil Han, Robert M Czerwinski, Nicole L Caspers, David C Limburg, WeiDong Ding, Mihir D Parikh

Biochem J· June 2014

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Biochemical, cellular, and anti-inflammatory properties of a potent, selective, orally bioavailable benzamide inhibitor of Rho kinase activity.
Lakshman E Rajagopalan, Michael S Davies, Larry E Kahn, Christine M Kornmeier, Hideaki Shimada, Mihir D Parikh

J Pharmacol Exp Ther· June 2010

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Structure-based drug design enables conversion of a DFG-in binding CSF-1R kinase inhibitor to a DFG-out binding mode.
Marvin J Meyers, Matthew Pelc, Satwik Kamtekar, Jacqueline Day, Gennadiy I Poda, Mihir D Parikh

Bioorg Med Chem Lett· March 2010

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Benzothiophene inhibitors of MK2. Part 2: improvements in kinase selectivity and cell potency.
David R Anderson, Marvin J Meyers, Ravi G Kurumbail, Nicole Caspers, Gennadiy I Poda, Mihir D Parikh

Bioorg Med Chem Lett· August 2009

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Discovery of +(2-{4-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethoxy]phenyl}-cyclopropyl)acetic acid as potent and selective alphavbeta3 inhibitor: design, synthesis, and optimization.
Srinivasan R Nagarajan, Hwang-Fun Lu, Alan F Gasiecki, Ish K Khanna, Mihir D Parikh

Bioorg Med Chem· May 2007

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