Publications by authors named "Mike Aylott"

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Evaluating Associations Between Nonclinical Cardiovascular Functional Endpoints and Repeat-dose Cardiovascular Toxicity in the Beagle Dog: A Cross-company Initiative.
Philip Milliken, Mike Aylott, Nick Edmunds, Steven Engle, Lorna Ewart

Toxicol Sci· July 2020

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Engineered hexavalent Fc proteins with enhanced Fc-gamma receptor avidity provide insights into immune-complex interactions.
Tania F Rowley, Shirley J Peters, Mike Aylott, Robert Griffin, Nicola L Davies

Commun Biol· September 2018

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The concordance between nonclinical and phase I clinical cardiovascular assessment from a cross-company data sharing initiative.
Lorna Ewart, Mike Aylott, Mark Deurinck, Mike Engwall, David J Gallacher

Toxicol Sci· December 2014

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Application of QbD principles for the evaluation of empty hard capsules as an input parameter in formulation development and manufacturing.
Sven Stegemann, Paul Connolly, Wayne Matthews, Rodger Barnett, Mike Aylott

AAPS PharmSciTech· June 2014

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Comparison of electrophysiological data from human-induced pluripotent stem cell-derived cardiomyocytes to functional preclinical safety assays.
Kate Harris, Mike Aylott, Yi Cui, James B Louttit, Nicholas C McMahon

Toxicol Sci· August 2013

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The in vivo rat skin photomicronucleus assay: phototoxicity and photogenotoxicity evaluation of six fluoroquinolones.
Astrid A Reus, Mustafa Usta, Julia D Kenny, Peter J Clements, Ingrid Pruimboom-Brees, Mike Aylott

Mutagenesis· November 2012

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Recommendations on the statistical analysis of the Comet assay.
Jonathan Bright, Mike Aylott, Simon Bate, Helena Geys, Philip Jarvis

Pharm Stat· May 2012

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An assessment of the statistical methods used to analyse toxicology studies.
Philip Jarvis, Jim Saul, Mike Aylott, Simon Bate, Helena Geys

Pharm Stat· May 2012

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Review of the statistical analysis of the dog telemetry study.
Mike Aylott, Simon Bate, Susie Collins, Philip Jarvis, Jim Saul

Pharm Stat· January 2012

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International Pig-a gene mutation assay trial (stage III): results with N-methyl-N-nitrosourea.
Anthony M Lynch, Amanda Giddings, Laura Custer, Carol Gleason, Andrew Henwood, Mike Aylott

Environ Mol Mutagen· December 2011

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The effects of the TRPV1 antagonist SB-705498 on TRPV1 receptor-mediated activity and inflammatory hyperalgesia in humans.
Boris A Chizh, Mary B O'Donnell, Antonella Napolitano, Jie Wang, Allison C Brooke, Mike C Aylott

Pain· November 2007

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Potential urinary and plasma biomarkers of peroxisome proliferation in the rat: identification of N-methylnicotinamide and N-methyl-4-pyridone-3-carboxamide by 1H nuclear magnetic resonance and high performance liquid chromatography.
Stephanie Ringeissen, Susan C Connor, H Roger Brown, Brian C Sweatman, Mark P Hodson, Mike C Aylott

Biomarkers· June 2004

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