Publications by authors named "Mike Firth"

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Dual inhibition of DNA-PK and Polϴ boosts precision of diverse prime editing systems.
Louis C Dacquay, Panagiotis Antoniou, Astrid Mentani, Niklas Selfjord, Hanna Mårtensson, Mike Firth

Nat Commun· May 2025

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Customizable virus-like particles deliver CRISPR-Cas9 ribonucleoprotein for effective ocular neovascular and Huntington's disease gene therapy.
Sikai Ling, Xue Zhang, Yao Dai, Zhuofan Jiang, Xujiao Zhou, Mike Firth

Nat Nanotechnol· April 2025

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Modified pegRNAs mitigate scaffold-derived prime editing by-products.
Panagiotis Antoniou, Louis Dacquay, Hanna Mårtensson, Katja Madeyski-Bengtson, Anna-Lena Loyd, Mike Firth

Nat Commun· April 2025

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Barcoded Hybrids of Extracellular Vesicles and Lipid Nanoparticles for Multiplexed Analysis of Tissue Distribution.
Alena Ivanova, Renata Chalupska, Ana Filipa Louro, Mike Firth, Hernán González-King Garibotti

Adv Sci (Weinh)· March 2025

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Optimized prime editing of the Alzheimer's disease-associated APOE4 mutation.
Antje K Rottner, Anders Lundin, Songyuan Li, Mike Firth, Marcello Maresca

Stem Cell Reports· January 2025

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Identification of cell type-specific cell-penetrating peptides through in vivo phage display leveraged by next generation sequencing.
Franziska Kohl, Oliver Laufkötter, Mike Firth, Luc Krimpenfort, Priyanka Mangla

Biomed Pharmacother· January 2025

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An aptamer-mediated base editing platform for simultaneous knockin and multiple gene knockout for allogeneic CAR-T cells generation.
Immacolata Porreca, Robert Blassberg, Jennifer Harbottle, Bronwyn Joubert, Olga Mielczarek, Mike Firth

Mol Ther· August 2024

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In vivo phage display identifies novel peptides for cardiac targeting.
Alena Ivanova, Franziska Kohl, Hernán González-King Garibotti, Renata Chalupska, Aleksander Cvjetkovic, Mike Firth

Sci Rep· May 2024

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Epigenetic modulators link mitochondrial redox homeostasis to cardiac function in a sex-dependent manner.
Zaher ElBeck, Mohammad Bakhtiar Hossain, Humam Siga, Nikolay Oskolkov, Fredrik Karlsson, Mike Firth

Nat Commun· March 2024

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A Type II-B Cas9 nuclease with minimized off-targets and reduced chromosomal translocations in vivo.
Burcu Bestas, Sandra Wimberger, Dmitrii Degtev, Alexandra Madsen, Antje K Rottner, Mike Firth

Nat Commun· September 2023

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Simultaneous inhibition of DNA-PK and Polϴ improves integration efficiency and precision of genome editing.
Sandra Wimberger, Nina Akrap, Mike Firth, Johan Brengdahl, Susanna Engberg

Nat Commun· August 2023

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Engineered Cas9 extracellular vesicles as a novel gene editing tool.
Xabier Osteikoetxea, Andreia Silva, Elisa Lázaro-Ibáñez, Nikki Salmond, Olga Shatnyeva, Mike Firth

J Extracell Vesicles· May 2022

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Harnessing DSB repair to promote efficient homology-dependent and -independent prime editing.
Martin Peterka, Nina Akrap, Songyuan Li, Sandra Wimberger, Pei-Pei Hsieh, Mike Firth

Nat Commun· March 2022

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Rapid target validation in a Cas9-inducible hiPSC derived kidney model.
Yasaman Shamshirgaran, Anna Jonebring, Anna Svensson, Isabelle Leefa, Mohammad Bohlooly-Y, Mike Firth

Sci Rep· August 2021

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Correction of a urea cycle defect after ex vivo gene editing of human hepatocytes.
Mihaela Zabulica, Raghuraman C Srinivasan, Pinar Akcakaya, Gabriella Allegri, Burcu Bestas, Mike Firth

Mol Ther· May 2021

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Author Correction: Universal toxin-based selection for precise genome engineering in human cells.
Songyuan Li, Nina Akrap, Silvia Cerboni, Michelle J Porritt, Sandra Wimberger, Mike Firth

Nat Commun· May 2021

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Universal toxin-based selection for precise genome engineering in human cells.
Songyuan Li, Nina Akrap, Silvia Cerboni, Michelle J Porritt, Sandra Wimberger, Mike Firth

Nat Commun· January 2021

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CRISPR GUARD protects off-target sites from Cas9 nuclease activity using short guide RNAs.
Matthew A Coelho, Etienne De Braekeleer, Mike Firth, Michal Bista, Sebastian Lukasiak

Nat Commun· August 2020

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Delivering Robust Candidates to the Drug Pipeline through Computational Analysis of Arrayed CRISPR Screens.
Maria Luisa Guerriero, Adam Corrigan, Aurélie Bornot, Mike Firth, Patrick O'Shea

SLAS Discov· July 2020

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A Novel Screening Approach for the Dissection of Cellular Regulatory Networks of NF-κB Using Arrayed CRISPR gRNA Libraries.
Patrick O'Shea, Jan Wildenhain, Mathew Leveridge, Chetana Revankar, Jian-Ping Yang, Mike Firth

SLAS Discov· July 2020

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Systematic Evaluation of CRISPRa and CRISPRi Modalities Enables Development of a Multiplexed, Orthogonal Gene Activation and Repression System.
Andrea Martella, Mike Firth, Benjamin J M Taylor, Anne Göppert, Emanuela M Cuomo

ACS Synth Biol· September 2019

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High-content phenotypic assay for proliferation of human iPSC-derived cardiomyocytes identifies L-type calcium channels as targets.
Laura A Woo, Svyatoslav Tkachenko, Mei Ding, Alleyn T Plowright, Ola Engkvist, Mike Firth

J Mol Cell Cardiol· February 2019

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BE-FLARE: a fluorescent reporter of base editing activity reveals editing characteristics of APOBEC3A and APOBEC3B.
Matthew A Coelho, Songyuan Li, Luna Simona Pane, Mike Firth, Giovanni Ciotta

BMC Biol· December 2018

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In vivo CRISPR editing with no detectable genome-wide off-target mutations.
Pinar Akcakaya, Maggie L Bobbin, Jimmy A Guo, Jose Malagon-Lopez, Kendell Clement, Mike A Firth

Nature· September 2018

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Pre-clinical pharmacology of AZD3965, a selective inhibitor of MCT1: DLBCL, NHL and Burkitt's lymphoma anti-tumor activity.
Nicola J Curtis, Lorraine Mooney, Lorna Hopcroft, Filippos Michopoulos, Nichola Whalley, Mike A Firth

Oncotarget· September 2017

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