Publications by authors named "Mikhail Linetsky"

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Radical-induced lipid oxidation produces a torrent of leukotriene-like agonists in severe asthma.
Si-Yang Liu, Mikhail Linetsky, Abby Hite, Yu-Shiuan Cheng, Masaru Miyagi

J Allergy Clin Immunol· October 2025

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Cysteinyl leukotriene-like metabolites are generated in retinal pigment epithelial cells through glutathionylation/reduction of an oxidatively truncated fragment of arachidonate.
Mikhail Linetsky, Anshula Mondal, Si-Yang Liu, Abby M Hite, Shravani Enduri

Results Chem· December 2023

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Glycation-mediated protein crosslinking and stiffening in mouse lenses are inhibited by carboxitin in vitro.
Sandip K Nandi, Johanna Rankenberg, Stefan Rakete, Rooban B Nahomi, Marcus A Glomb, Mikhail D Linetsky

Glycoconj J· June 2021

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4-Hydroxy-7-oxo-5-heptenoic acid lactone can induce mitochondrial dysfunction in retinal pigmented epithelial cells.
Yu-Shiuan Cheng, Mikhail Linetsky, Haoting Li, Naji Ayyash, Anthony Gardella

Free Radic Biol Med· November 2020

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4-Hydroxy-7-oxo-5-heptenoic acid (HOHA) lactone induces apoptosis in retinal pigment epithelial cells.
Mikhail Linetsky, Junhong Guo, Emeka Udeigwe, Duoming Ma, Amanda S Chamberlain

Free Radic Biol Med· May 2020

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Toll-like Receptor 2 Facilitates Oxidative Damage-Induced Retinal Degeneration.
Kelly Mulfaul, Ema Ozaki, Nilisha Fernando, Kiva Brennan, Kathleen R Chirco, Mikhail Linetsky

Cell Rep· February 2020

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The Adductomics of Isolevuglandins: Oxidation of IsoLG Pyrrole Intermediates Generates Pyrrole⁻Pyrrole Crosslinks and Lactams.
Wenzhao Bi, Geeng-Fu Jang, Lei Zhang, John W Crabb, James Laird, Mikhail Linetsky

High Throughput· May 2019

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Light-induced generation and toxicity of docosahexaenoate-derived oxidation products in retinal pigmented epithelial cells.
Yu-Shiuan Cheng, Mikhail Linetsky, Xilin Gu, Naji Ayyash, Anthony Gardella

Exp Eye Res· April 2019

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4-Hydroxy-7-oxo-5-heptenoic Acid Lactone Is a Potent Inducer of the Complement Pathway in Human Retinal Pigmented Epithelial Cells.
Mikhail Linetsky, Karina S Bondelid, Sofiya Losovskiy, Vadym Gabyak, Mario J Rullo

Chem Res Toxicol· August 2018

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High-resolution dynamic oxygen-17 MR imaging of mouse brain with golden-ratio-based radial sampling and k-space-weighted image reconstruction.
Yuchi Liu, Yifan Zhang, Chunying Wu, Junqing Zhu, Charlie Wang, Mikhail D Linetsky

Magn Reson Med· January 2018

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4-Hydroxy-7-oxo-5-heptenoic Acid Lactone Induces Angiogenesis through Several Different Molecular Pathways.
Junhong Guo, Mikhail Linetsky, Annabelle O Yu, Liang Zhang, Scott J Howell

Chem Res Toxicol· December 2016

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Molecular Structures of Isolevuglandin-Protein Cross-Links.
Wenzhao Bi, Geeng-Fu Jang, Lei Zhang, John W Crabb, James Laird, Mikhail Linetsky

Chem Res Toxicol· October 2016

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Metabolism of 4-Hydroxy-7-oxo-5-heptenoic Acid (HOHA) Lactone by Retinal Pigmented Epithelial Cells.
Hua Wang, Mikhail Linetsky, Junhong Guo, Annabelle O Yu, Robert G Salomon

Chem Res Toxicol· July 2016

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4-Hydroxy-7-oxo-5-heptenoic Acid (HOHA) Lactone is a Biologically Active Precursor for the Generation of 2-(ω-Carboxyethyl)pyrrole (CEP) Derivatives of Proteins and Ethanolamine Phospholipids.
Hua Wang, Mikhail Linetsky, Junhong Guo, Jaewoo Choi, Li Hong

Chem Res Toxicol· May 2015

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Detection and biological activities of carboxyethylpyrrole ethanolamine phospholipids (CEP-EPs).
Hua Wang, Junhong Guo, Xiaoxia Z West, Hemant K Bid, Liang Lu, Mikhail Linetsky

Chem Res Toxicol· December 2014

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UVA light-excited kynurenines oxidize ascorbate and modify lens proteins through the formation of advanced glycation end products: implications for human lens aging and cataract formation.
Mikhail Linetsky, Cibin T Raghavan, Kaid Johar, Xingjun Fan, Vincent M Monnier

J Biol Chem· June 2014

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The pathogenic role of Maillard reaction in the aging eye.
Ram H Nagaraj, Mikhail Linetsky, Alan W Stitt

Amino Acids· April 2012

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Acetylation of αA-crystallin in the human lens: effects on structure and chaperone function.
Ram H Nagaraj, Rooban B Nahomi, Shilpa Shanthakumar, Mikhail Linetsky, Smitha Padmanabha

Biochim Biophys Acta· February 2012

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Determination of dideoxyosone precursors of AGEs in human lens proteins.
Mikhail Linetsky, S R Kaid Johar, Jasmin Meltretter, Smitha Padmanabha, Trilok Parmar

Arch Biochem Biophys· October 2011

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Modulation of advanced glycation endproduct synthesis by kynurenines in human lens proteins.
Ram H Nagaraj, Smitha Padmanabha, Maneesh Mailankot, Magdalena Staniszewska, Liew Jun Mun, Mikhail D Linetsky

Biochim Biophys Acta· April 2010

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Hydroimidazolone modification of human alphaA-crystallin: Effect on the chaperone function and protein refolding ability.
Mahesha H Gangadhariah, Benlian Wang, Mikhail Linetsky, Christian Henning, Robert Spanneberg

Biochim Biophys Acta· April 2010

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Glycation by ascorbic acid oxidation products leads to the aggregation of lens proteins.
Mikhail Linetsky, Ekaterina Shipova, Rongzhu Cheng, Beryl J Ortwerth

Biochim Biophys Acta· January 2008

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Influence of glutathione fructosylation on its properties.
Mikhail Linetsky, Ekaterina V Shipova, Ognyan K Argirov

Arch Biochem Biophys· May 2006

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Glucose-derived Amadori compounds of glutathione.
Mikhail D Linetsky, Ekaterina V Shipova, Roy D Legrand, Ognyan O Argirov

Biochim Biophys Acta· June 2005

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Glutathionylation of lens proteins through the formation of thioether bond.
Mikhail Linetsky, Roy D LeGrand

Mol Cell Biochem· April 2005

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