Publications by authors named "Milan Reinis"

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Novel PD-1-targeted, activity-optimized IL-15 mutein SOT201 acting in cis provides antitumor activity superior to PD1-IL2v.
Hana Matuskova, Pavel Marasek, Vladyslav Mazhara, Ekaterina Simonova, Lucie Kosinova, Milan Reinis

J Immunother Cancer· April 2025

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Nanrilkefusp alfa (SOT101), an IL-15 receptor βγ superagonist, as a single agent or with anti-PD-1 in patients with advanced cancers.
Stephane Champiat, Elena Garralda, Vladimir Galvao, Philippe A Cassier, Carlos Gomez-Roca, Milan Reinis

Cell Rep Med· February 2025

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Discovery of a 6-Aminobenzo[]thiophene 1,1-Dioxide Derivative (K2071) with a Signal Transducer and Activator of Transcription 3 Inhibitory, Antimitotic, and Senotherapeutic Activities.
Patrik Oleksak, David Rysanek, Marketa Vancurova, Pavla Vasicova, Alexandra Urbancokova, Milan Reinis

ACS Pharmacol Transl Sci· September 2024

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PEGylated Molybdenum-Iodine Nanocluster as a Promising Radiodynamic Agent against Prostatic Adenocarcinoma.
Tomáš Přibyl, Michaela Rumlová, Romana Mikyšková, Milan Reiniš, Antonín Kaňa

Inorg Chem· March 2024

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STAT3 inhibitor Stattic and its analogues inhibit STAT3 phosphorylation and modulate cytokine secretion in senescent tumour cells.
Romana Mikyskova, Olena Sapega, Miroslav Psotka, Ondrej Novotny, Zdeněk Hodny, Milan Reinis

Mol Med Rep· April 2023

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Type I interferon signaling in malignant blasts contributes to treatment efficacy in AML patients.
Peter Holicek, Iva Truxova, Jana Rakova, Cyril Salek, Michal Hensler, Milan Reinis

Cell Death Dis· March 2023

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Chronic inflammation decreases HSC fitness by activating the druggable Jak/Stat3 signaling pathway.
Srdjan Grusanovic, Petr Danek, Maria Kuzmina, Miroslava K Adamcova, Monika Burocziova, Milan Reinis

EMBO Rep· January 2023

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Discovery of small molecule mechanistic target of rapamycin inhibitors as anti-aging and anti-cancer therapeutics.
Zofia Chrienova, David Rysanek, Patrik Oleksak, Dorota Stary, Marek Bajda, Milan Reinis

Front Aging Neurosci· December 2022

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Avenue to X-ray-induced photodynamic therapy of prostatic carcinoma with octahedral molybdenum cluster nanoparticles.
Martina Koncošová, Michaela Rumlová, Romana Mikyšková, Milan Reiniš, Jaroslav Zelenka

J Mater Chem B· May 2022

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Design, synthesis, and evaluation of BP-1-102 analogs with modified hydrophobic fragments for STAT3 inhibition.
Patrik Oleksak, Miroslav Psotka, Marketa Vancurova, Olena Sapega, Jana Bieblova, Milan Reinis

J Enzyme Inhib Med Chem· December 2021

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Calreticulin exposure on malignant blasts correlates with improved natural killer cell-mediated cytotoxicity in acute myeloid leukemia patients.
Iva Truxova, Lenka Kasikova, Cyril Salek, Michal Hensler, Daniel Lysak, Milan Reinis

Haematologica· July 2020

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Distinct phenotypes and 'bystander' effects of senescent tumour cells induced by docetaxel or immunomodulatory cytokines.
Olena Sapega, Romana Mikyšková, Jana Bieblová, Blanka Mrázková, Zdeněk Hodný

Int J Oncol· November 2018

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Biological safety and tissue distribution of (16-mercaptohexadecyl)trimethylammonium bromide-modified cationic gold nanorods.
Monika Zarska, Michal Sramek, Filip Novotny, Filip Havel, Andrea Babelova, Milan Reinis

Biomaterials· February 2018

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Dendritic cells pulsed with tumor cells killed by high hydrostatic pressure inhibit prostate tumor growth in TRAMP mice.
Romana Mikyskova, Marie Indrova, Ivan Stepanek, Ivan Kanchev, Jana Bieblova, Milan Reinis

Oncoimmunology· August 2017

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Resistance of novel mouse strains different in MHC class I and the NKC domain to the development of experimental tumors.
Anna Fišerová, Jan Richter, Katarína Čapková, Jana Bieblová, Romana Mikyšková

Int J Oncol· August 2016

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Tumor growth accelerated by chemotherapy-induced senescent cells is suppressed by treatment with IL-12 producing cellular vaccines.
Jana Simova, Olena Sapega, Terezie Imrichova, Ivan Stepanek, Lenka Kyjacova, Milan Reinis

Oncotarget· August 2016

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Dynamic alterations of bone marrow cytokine landscape of myelodysplastic syndromes patients treated with 5-azacytidine.
Alena Moudra, Sona Hubackova, Veronika Machalova, Marketa Vancurova, Jiri Bartek, Milan Reinis

Oncoimmunology· May 2016

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Dendritic cells pulsed with tumor cells killed by high hydrostatic pressure induce strong immune responses and display therapeutic effects both in murine TC-1 and TRAMP-C2 tumors when combined with docetaxel chemotherapy.
Romana Mikyšková, Ivan Štěpánek, Marie Indrová, Jana Bieblová, Jana Šímová

Int J Oncol· March 2016

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Interferon gamma/NADPH oxidase defense system in immunity and cancer.
Zdenek Hodny, Milan Reinis, Sona Hubackova, Pavla Vasicova, Jiri Bartek

Oncoimmunology· February 2016

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Epigenetic regulations in the IFNγ signalling pathway: IFNγ-mediated MHC class I upregulation on tumour cells is associated with DNA demethylation of antigen-presenting machinery genes.
Veronika Vlková, Ivan Štěpánek, Veronika Hrušková, Filip Šenigl, Veronika Mayerová

Oncotarget· August 2014

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DNA demethylating agent 5-azacytidine inhibits myeloid-derived suppressor cells induced by tumor growth and cyclophosphamide treatment.
Romana Mikyšková, Marie Indrová, Veronika Vlková, Jana Bieblová, Jana Šímová

J Leukoc Biol· May 2014

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Administration of anti-CD25 mAb leads to impaired α-galactosylceramide-mediated induction of IFN-γ production in a murine model.
Rodney A Rosalia, Ivan Štěpánek, Veronika Polláková, Jana Šímová, Jana Bieblová

Immunobiology· June 2013

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Cyclophosphamide-induced myeloid-derived suppressor cell population is immunosuppressive but not identical to myeloid-derived suppressor cells induced by growing TC-1 tumors.
Romana Mikyšková, Marie Indrová, Veronika Polláková, Jana Bieblová, Jana Símová

J Immunother· June 2012

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Genetically modified tumour vaccines producing IL-12 augment chemotherapy of HPV16-associated tumours with gemcitabine.
Romana Mikyšková, Marie Indrová, Jana Símová, Jana Bieblová, Jan Bubeník

Oncol Rep· June 2011

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NK1.1+ cells are important for the development of protective immunity against MHC I-deficient, HPV16-associated tumours.
Marie Indrová, Jana Símová, Jana Bieblová, Jan Bubeník, Milan Reinis

Oncol Rep· January 2011

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