Publications by authors named "Mio Mejima"

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MucoRice-CTB line 19A, a new marker-free transgenic rice-based cholera vaccine produced in an LED-based hydroponic system.
Yoshikazu Yuki, Shiho Kurokawa, Kotomi Sugiura, Koji Kashima, Shinichi Maruyama, Mio Mejima

Front Plant Sci· March 2024

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Oral MucoRice-CTB vaccine for safety and microbiota-dependent immunogenicity in humans: a phase 1 randomised trial.
Yoshikazu Yuki, Masanori Nojima, Osamu Hosono, Hirotoshi Tanaka, Yasumasa Kimura, Mio Mejima

Lancet Microbe· September 2021

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Seed Metabolome Analysis of a Transgenic Rice Line Expressing Cholera Toxin B-subunit.
Takumi Ogawa, Koji Kashima, Yoshikazu Yuki, Mio Mejima, Shiho Kurokawa

Sci Rep· July 2017

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Differential analyses of major allergen proteins in wild-type rice and rice producing a fragment of anti-rotavirus antibody.
Yoshikazu Yuki, Shiho Kurokawa, Hiroko Kozuka-Hata, Daisuke Tokuhara, Mio Mejima

Regul Toxicol Pharmacol· April 2016

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Good manufacturing practices production of a purification-free oral cholera vaccine expressed in transgenic rice plants.
Koji Kashima, Yoshikazu Yuki, Mio Mejima, Shiho Kurokawa, Yuji Suzuki

Plant Cell Rep· March 2016

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Oral rice-based vaccine induces passive and active immunity against enterotoxigenic E. coli-mediated diarrhea in pigs.
Natsumi Takeyama, Yoshikazu Yuki, Daisuke Tokuhara, Kazuki Oroku, Mio Mejima

Vaccine· September 2015

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Comparative whole-genome analyses of selection marker-free rice-based cholera toxin B-subunit vaccine lines and wild-type lines.
Koji Kashima, Mio Mejima, Shiho Kurokawa, Masaharu Kuroda, Hiroshi Kiyono

BMC Genomics· February 2015

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Specific expression of apolipoprotein A-IV in the follicle-associated epithelium of the small intestine.
Daisuke Tokuhara, Tomonori Nochi, Akiko Matsumura, Mio Mejima, Yuko Takahashi

Dig Dis Sci· November 2014

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A rice-based soluble form of a murine TNF-specific llama variable domain of heavy-chain antibody suppresses collagen-induced arthritis in mice.
Michiyo Abe, Yoshikazu Yuki, Shiho Kurokawa, Mio Mejima, Masaharu Kuroda

J Biotechnol· April 2014

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RNAi-mediated suppression of endogenous storage proteins leads to a change in localization of overexpressed cholera toxin B-subunit and the allergen protein RAG2 in rice seeds.
Shiho Kurokawa, Masaharu Kuroda, Mio Mejima, Rika Nakamura, Yuko Takahashi

Plant Cell Rep· January 2014

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Induction of toxin-specific neutralizing immunity by molecularly uniform rice-based oral cholera toxin B subunit vaccine without plant-associated sugar modification.
Yoshikazu Yuki, Mio Mejima, Shiho Kurokawa, Tomoko Hiroiwa, Yuko Takahashi

Plant Biotechnol J· September 2013

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Rice-based oral antibody fragment prophylaxis and therapy against rotavirus infection.
Daisuke Tokuhara, Beatriz Álvarez, Mio Mejima, Tomoko Hiroiwa, Yuko Takahashi

J Clin Invest· September 2013

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MucoRice-cholera toxin B-subunit, a rice-based oral cholera vaccine, down-regulates the expression of α-amylase/trypsin inhibitor-like protein family as major rice allergens.
Shiho Kurokawa, Rika Nakamura, Mio Mejima, Hiroko Kozuka-Hata, Masaharu Kuroda

J Proteome Res· July 2013

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Nanogel-based PspA intranasal vaccine prevents invasive disease and nasal colonization by Streptococcus pneumoniae.
Il Gyu Kong, Ayuko Sato, Yoshikazu Yuki, Tomonori Nochi, Haruko Takahashi, Mio Mejima

Infect Immun· May 2013

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RNAi suppression of rice endogenous storage proteins enhances the production of rice-based Botulinum neutrotoxin type A vaccine.
Yoshikazu Yuki, Mio Mejima, Shiho Kurokawa, Tomoko Hiroiwa, Il Gyu Kong

Vaccine· June 2012

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In vivo molecular imaging analysis of a nasal vaccine that induces protective immunity against botulism in nonhuman primates.
Yoshikazu Yuki, Tomonori Nochi, Norihiro Harada, Yuko Katakai, Hiroaki Shibata, Mio Mejima

J Immunol· November 2010

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Nanogel antigenic protein-delivery system for adjuvant-free intranasal vaccines.
Tomonori Nochi, Yoshikazu Yuki, Haruko Takahashi, Shin-ichi Sawada, Mio Mejima

Nat Mater· July 2010

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Secretory IgA-mediated protection against V. cholerae and heat-labile enterotoxin-producing enterotoxigenic Escherichia coli by rice-based vaccine.
Daisuke Tokuhara, Yoshikazu Yuki, Tomonori Nochi, Toshio Kodama, Mio Mejima

Proc Natl Acad Sci U S A· May 2010

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A rice-based oral cholera vaccine induces macaque-specific systemic neutralizing antibodies but does not influence pre-existing intestinal immunity.
Tomonori Nochi, Yoshikazu Yuki, Yuko Katakai, Hiroaki Shibata, Daisuke Tokuhara, Mio Mejima

J Immunol· November 2009

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Oral MucoRice expressing double-mutant cholera toxin A and B subunits induces toxin-specific neutralising immunity.
Yoshikazu Yuki, Daisuke Tokuhara, Tomonori Nochi, Hiroshi Yasuda, Mio Mejima

Vaccine· October 2009

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Comprehensive gene expression profiling of Peyer's patch M cells, villous M-like cells, and intestinal epithelial cells.
Kazutaka Terahara, Masato Yoshida, Osamu Igarashi, Tomonori Nochi, Gemilson Soares Pontes, Mio Mejima

J Immunol· June 2008

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A novel M cell-specific carbohydrate-targeted mucosal vaccine effectively induces antigen-specific immune responses.
Tomonori Nochi, Yoshikazu Yuki, Akiko Matsumura, Mio Mejima, Kazutaka Terahara

J Exp Med· November 2007

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Rice-based mucosal vaccine as a global strategy for cold-chain- and needle-free vaccination.
Tomonori Nochi, Hidenori Takagi, Yoshikazu Yuki, Lijun Yang, Takehiro Masumura, Mio Mejima

Proc Natl Acad Sci U S A· June 2007

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