Publications by authors named "Misato Hashizume"

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Effectiveness and safety of tocilizumab, an anti-interleukin-6 receptor antibody, in 342 Japanese patients with multicentric Castleman disease: a 3-year, prospective, observational study.
Norihiro Nishimoto, Miho Murakami, Takeshi Johkoh, Seiji Hayashi, Shiro Ohshima, Misato Hashizume

Mod Rheumatol· October 2025

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A phase 2 study of polatuzumab vedotin + bendamustine + rituximab in relapsed/refractory diffuse large B-cell lymphoma.
Yasuhito Terui, Shinya Rai, Koji Izutsu, Motoko Yamaguchi, Jun Takizawa, Misato Hashizume

Cancer Sci· July 2021

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Outlook of IL-6 signaling blockade for COVID-19 pneumonia.
Misato Hashizume

Inflamm Regen· October 2020

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Translating IL-6 biology into effective treatments.
Ernest H Choy, Fabrizio De Benedetti, Tsutomu Takeuchi, Misato Hashizume, Markus R John

Nat Rev Rheumatol· June 2020

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Discriminating phenotypic signatures identified for tocilizumab, adalimumab, and tofacitinib monotherapy and their combinations with methotrexate.
Alison O'Mahony, Markus R John, Hannah Cho, Misato Hashizume, Ernest H Choy

J Transl Med· June 2018

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Host interleukin 6 production regulates inflammation but not tryptophan metabolism in the brain during murine GVHD.
Ludovic Belle, Vivian Zhou, Kara L Stuhr, Margaret Beatka, Emily M Siebers, Misato Hashizume

JCI Insight· July 2017

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Baseline Serum Osteopontin Levels Predict the Clinical Effectiveness of Tocilizumab but Not Infliximab in Biologic-Naïve Patients with Rheumatoid Arthritis: A Single-Center Prospective Study at 1 Year (the Keio First-Bio Cohort Study).
Keisuke Izumi, Yuko Kaneko, Misato Hashizume, Keiko Yoshimoto, Tsutomu Takeuchi

PLoS One· July 2016

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Correction: Baseline Serum Osteopontin Levels Predict the Clinical Effectiveness of Tocilizumab but Not Infliximab in Biologic-Naïve Patients with Rheumatoid Arthritis: A Single-Center Prospective Study at 1 Year (the Keio First-Bio Cohort Study).
Keisuke Izumi, Yuko Kaneko, Misato Hashizume, Keiko Yoshimoto, Tsutomu Takeuchi

PLoS One· July 2016

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Tocilizumab, a humanized anti-IL-6R antibody, as an emerging therapeutic option for rheumatoid arthritis: molecular and cellular mechanistic insights.
Misato Hashizume, Seng-Lai Tan, Junichi Takano, Kazunori Ohsawa, Ikuo Hasada

Int Rev Immunol· May 2015

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IL-6 as a target in inflammation.
Misato Hashizume, Yoshiyuki Ohsugi

Endocr Metab Immune Disord Drug Targets· March 2015

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Peripheral blood CD4(+)CD25(+)CD127(low) regulatory T cells are significantly increased by tocilizumab treatment in patients with rheumatoid arthritis: increase in regulatory T cells correlates with clinical response.
Jun Kikuchi, Misato Hashizume, Yuko Kaneko, Keiko Yoshimoto, Naoshi Nishina

Arthritis Res Ther· January 2015

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[IL-6 as a target in autoimmune disease and inflammation].
Misato Hashizume, Yoshiyuki Ohsugi

Nihon Yakurigaku Zasshi· October 2014

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Baseline levels of soluble interleukin-6 receptor predict clinical remission in patients with rheumatoid arthritis treated with tocilizumab: implications for molecular targeted therapy.
Naoshi Nishina, Jun Kikuchi, Misato Hashizume, Keiko Yoshimoto, Hideto Kameda

Ann Rheum Dis· May 2014

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Anti-interleukin-6 receptor antibody prevents systemic bone mass loss via reducing the number of osteoclast precursors in bone marrow in a collagen-induced arthritis model.
Keisuke Tanaka, Misato Hashizume, Masahiko Mihara, Hiroto Yoshida, Miho Suzuki

Clin Exp Immunol· February 2014

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Blockade of IL-6 and TNF-α inhibited oxLDL-induced production of MCP-1 via scavenger receptor induction.
Misato Hashizume, Masahiko Mihara

Eur J Pharmacol· August 2012

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Atherogenic effects of TNF-α and IL-6 via up-regulation of scavenger receptors.
Misato Hashizume, Masahiko Mihara

Cytokine· June 2012

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Interleukin-6 regulates anti-arthritic effect of methotrexate via reduction of SLC19A1 expression in a mouse arthritis model.
Misato Hashizume, Hiroto Yoshida, Keisuke Tanaka, Miho Suzuki, Isao Matsumoto

Arthritis Res Ther· April 2012

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IL-6/IL-6 receptor system and its role in physiological and pathological conditions.
Masahiko Mihara, Misato Hashizume, Hiroto Yoshida, Miho Suzuki, Masashi Shiina

Clin Sci (Lond)· February 2012

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Induction of high-dose tolerance to the rat anti-mouse IL-6 receptor antibody in NZB/NZW F1 mice.
Hiroto Yoshida, Misato Hashizume, Miho Suzuki, Masahiko Mihara

Rheumatol Int· November 2011

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The roles of interleukin-6 in the pathogenesis of rheumatoid arthritis.
Misato Hashizume, Masahiko Mihara

Arthritis· November 2011

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IL-6 plays an essential role in neutrophilia under inflammation.
Misato Hashizume, Yoshinobu Higuchi, Yasushi Uchiyama, Masahiko Mihara

Cytokine· April 2011

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IL-6 blockade preferentially inhibits Th17 differentiation in collagen-induced arthritis.
Hiroto Yoshida, Misato Hashizume, Masahiko Mihara

Rheumatol Int· January 2011

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High molecular weight hyaluronic acid inhibits IL-6-induced MMP production from human chondrocytes by up-regulating the ERK inhibitor, MKP-1.
Misato Hashizume, Masahiko Mihara

Biochem Biophys Res Commun· December 2010

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High molecular weight hyaluronic acid relieved joint pain and prevented the progression of cartilage degeneration in a rabbit osteoarthritis model after onset of arthritis.
Misato Hashizume, Nobuo Koike, Hiroto Yoshida, Miho Suzuki, Masahiko Mihara

Mod Rheumatol· October 2010

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Striking species difference in the contribution of concentrative nucleoside transporter 2 to nucleoside uptake between mouse and rat hepatocytes.
Tomomi Furihata, Yukina Fukuchi, Minami Iikura, Misato Hashizume, Atsushi Miyajima

Antimicrob Agents Chemother· July 2010

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