Publications by authors named "Mitchell Cheung"

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Alterations of the AKT Pathway in Sporadic Human Tumors, Inherited Susceptibility to Cancer, and Overgrowth Syndromes.
Craig W Menges, Dalal Hassan, Mitchell Cheung, Alfonso Bellacosa, Joseph R Testa

Curr Top Microbiol Immunol· August 2024

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Low Exposures to Amphibole or Serpentine Asbestos in Germline Bap1-mutant Mice Induce Mesothelioma Characterized by an Immunosuppressive Tumor Microenvironment.
Yuwaraj Kadariya, Eleonora Sementino, Maggie Ruan, Mitchell Cheung, Parham Hadikhani

Cancer Res Commun· April 2024

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Inactivation of p21-Activated Kinase 2 (Pak2) Inhibits the Development of Nf2-Deficient Tumors by Restricting Downstream Hedgehog and Wnt Signaling.
Eleonora Sementino, Yuwaraj Kadariya, Mitchell Cheung, Craig W Menges, Yinfei Tan

Mol Cancer Res· May 2022

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Novel LRRK2 mutations and other rare, non-BAP1-related candidate tumor predisposition gene variants in high-risk cancer families with mesothelioma and other tumors.
Mitchell Cheung, Yuwaraj Kadariya, Eleonora Sementino, Michael J Hall, Ilaria Cozzi

Hum Mol Genet· August 2021

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Kinetic Characterization of ASXL1/2-Mediated Allosteric Regulation of the BAP1 Deubiquitinase.
Hongzhuang Peng, Joel Cassel, Daniel S McCracken, Jeremy W Prokop, Eleonora Sementino, Mitchell Cheung

Mol Cancer Res· July 2021

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Somatic Epigenetic Silencing of Inactivates Necroptosis and Contributes to Chemoresistance in Malignant Mesothelioma.
Yinfei Tan, Eleonora Sementino, Mitchell Cheung, Suraj Peri, Craig W Menges

Clin Cancer Res· February 2021

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Inactivation of Cooperates with Losses of and to Drive the Development of Pleural Malignant Mesothelioma in Conditional Mouse Models.
Anna-Mariya Kukuyan, Eleonora Sementino, Yuwaraj Kadariya, Craig W Menges, Mitchell Cheung

Cancer Res· August 2019

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Comprehensive Study of the Clinical Phenotype of Germline BAP1 Variant-Carrying Families Worldwide.
Sebastian Walpole, Antonia L Pritchard, Colleen M Cebulla, Robert Pilarski, Meredith Stautberg, Mitchell Cheung

J Natl Cancer Inst· December 2018

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Familial and Somatic Mutations Inactivate ASXL1/2-Mediated Allosteric Regulation of BAP1 Deubiquitinase by Targeting Multiple Independent Domains.
Hongzhuang Peng, Jeremy Prokop, Jayashree Karar, Kyewon Park, Li Cao, Mitchell Cheung

Cancer Res· March 2018

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, a tumor suppressor gene driving malignant mesothelioma.
Mitchell Cheung, Joseph R Testa

Transl Lung Cancer Res· June 2017

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Haploinsufficiency in tumor predisposition syndromes: altered genomic transcription in morphologically normal cells heterozygous for VHL or TSC mutation.
Suraj Peri, Elena Caretti, Rossella Tricarico, Karthik Devarajan, Mitchell Cheung

Oncotarget· March 2017

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Bap1 Is a Bona Fide Tumor Suppressor: Genetic Evidence from Mouse Models Carrying Heterozygous Germline Bap1 Mutations.
Yuwaraj Kadariya, Mitchell Cheung, Jinfei Xu, Jianming Pei, Eleonora Sementino

Cancer Res· May 2016

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Inflammation-Related IL1β/IL1R Signaling Promotes the Development of Asbestos-Induced Malignant Mesothelioma.
Yuwaraj Kadariya, Craig W Menges, Jacqueline Talarchek, Kathy Q Cai, Andres J Klein-Szanto, Mitchell Cheung

Cancer Prev Res (Phila)· May 2016

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Germline BAP1 Mutational Landscape of Asbestos-Exposed Malignant Mesothelioma Patients with Family History of Cancer.
Jill A Ohar, Mitchell Cheung, Jacqueline Talarchek, Suzanne E Howard, Timothy D Howard

Cancer Res· January 2016

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Germline BAP1 mutation in a family with high incidence of multiple primary cancers and a potential gene-environment interaction.
Mitchell Cheung, Yuwaraj Kadariya, Jacqueline Talarchek, Jianming Pei, Jill A Ohar

Cancer Lett· December 2015

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An asbestos-exposed family with multiple cases of pleural malignant mesothelioma without inheritance of a predisposing BAP1 mutation.
Mitchell Cheung, Yuwaraj Kadariya, Jianming Pei, Jacqueline Talarchek, Francesco Facciolo

Cancer Genet· October 2015

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Mesothelioma patient derived tumor xenografts with defined BAP1 mutations that mimic the molecular characteristics of human malignant mesothelioma.
Neetu Kalra, Jingli Zhang, Anish Thomas, Liqiang Xi, Mitchell Cheung

BMC Cancer· May 2015

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Germline mutation of Bap1 accelerates development of asbestos-induced malignant mesothelioma.
Jinfei Xu, Yuwaraj Kadariya, Mitchell Cheung, Jianming Pei, Jacqueline Talarchek

Cancer Res· August 2014

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Copy neutral loss of heterozygosity in 20q in chronic lymphocytic leukemia/small lymphocytic lymphoma.
Jianming Pei, Valentin Robu, Madelyn Feder, Mitchell Cheung, Erin Neumann-Domer

Cancer Genet· March 2014

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NF-κB inhibition by bortezomib permits IFN-γ-activated RIP1 kinase-dependent necrosis in renal cell carcinoma.
Roshan J Thapa, Peirong Chen, Mitchell Cheung, Shoko Nogusa, Jianming Pei

Mol Cancer Ther· August 2013

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Further evidence for germline BAP1 mutations predisposing to melanoma and malignant mesothelioma.
Mitchell Cheung, Jacqueline Talarchek, Karen Schindeler, Eduardo Saraiva, Lynette S Penney

Cancer Genet· May 2013

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Diverse mechanisms of AKT pathway activation in human malignancy.
Mitchell Cheung, Joseph R Testa

Curr Cancer Drug Targets· March 2013

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Germline BAP1 mutations predispose to malignant mesothelioma.
Joseph R Testa, Mitchell Cheung, Jianming Pei, Jennifer E Below, Yinfei Tan

Nat Genet· August 2011

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Upregulation of DLX5 promotes ovarian cancer cell proliferation by enhancing IRS-2-AKT signaling.
Yinfei Tan, Mitchell Cheung, Jianming Pei, Craig W Menges, Andrew K Godwin

Cancer Res· November 2010

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Onconase responsive genes in human mesothelioma cells: implications for an RNA damaging therapeutic agent.
Deborah A Altomare, Susanna M Rybak, Jianming Pei, Jacob V Maizel, Mitchell Cheung

BMC Cancer· February 2010

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