Publications by authors named "Mitchell Gulkis"

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Design, anticancer activity, and mechanistic evaluation of a novel class of selective human carbonic anhydrase IX inhibitors featuring a trifluorodihydroxypropanone pharmacophore.
Nicolino Pala, Federico Ladu, Wojciech Szlasa, Roberta Cadoni, Carrie Lomelino, Mitchell Gulkis

Eur J Med Chem· November 2025

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Off-target binding of the histone deacetylase inhibitor vorinostat to carbonic anhydrase II and IX.
Mitchell C Gulkis, James T Hodgkinson, Céleste P Sele, Wolfgang Knecht, Robert McKenna

Acta Crystallogr F Struct Biol Commun· September 2025

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Impact of DNA ligase inhibition on the nick sealing of polβ nucleotide insertion products at the downstream steps of base excision repair pathway.
Danah Almohdar, Pradnya Kamble, Chandrakala Basavannacharya, Mitchell Gulkis, Ozlem Calbay

Mutagenesis· November 2024

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Probing the mechanism of nick searching by LIG1 at the single-molecule level.
Surajit Chatterjee, Loïc Chaubet, Aafke van den Berg, Ann Mukhortava, Danah Almohdar, Mitchell Gulkis

Nucleic Acids Res· November 2024

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Biochemical, structural, and single-molecule characterization of LIG1 active site mutants demonstrate role of F635 and F872 residues for faithful ligation.
Mustafa Kalaycioğlu, Mitchell Gulkis, Kar Men Lee, Surajit Chatterjee, Kanal Balu

bioRxiv· November 2024

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Structural Characterization of Human Bufavirus 1: Receptor Binding and Endosomal pH-Induced Changes.
Mitchell Gulkis, Mengxiao Luo, Paul Chipman, Mario Mietzsch, Maria Söderlund-Venermo

Viruses· August 2024

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Structures of LIG1 provide a mechanistic basis for understanding a lack of sugar discrimination against a ribonucleotide at the 3'-end of nick DNA.
Kanal Elamparithi Balu, Mitchell Gulkis, Danah Almohdar, Melike Çağlayan

J Biol Chem· May 2024

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Unfilled gaps by polβ lead to aberrant ligation by LIG1 at the downstream steps of base excision repair pathway.
Mitchell Gulkis, Ernesto Martinez, Danah Almohdar, Melike Çağlayan

Nucleic Acids Res· April 2024

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Molecular editing of enabling discovery of benzodithiazinedioxide-guanidines as anticancer agents.
Vajja Krishna Rao, Subarno Paul, Mitchell Gulkis, Zhihang Shen, Haritha Nair

RSC Med Chem· March 2024

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Impact of polβ/XRCC1 Interaction Variants on the Efficiency of Nick Sealing by DNA Ligase IIIα in the Base Excision Repair Pathway.
Danah Almohdar, Mitchell Gulkis, Abigail Ortiz, Qun Tang, Robert W Sobol

J Mol Biol· February 2024

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Structures of LIG1 active site mutants reveal the importance of DNA end rigidity for mismatch discrimination.
Mitchell Gulkis, Qun Tang, Matthew Petrides, Melike Çağlayan

Res Sq· April 2023

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Structures of LIG1 active site mutants reveal the importance of DNA end rigidity for mismatch discrimination.
Mitchell Gulkis, Qun Tang, Matthew Petrides, Melike Çağlayan

bioRxiv· March 2023

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Structures of LIG1 that engage with mutagenic mismatches inserted by polβ in base excision repair.
Qun Tang, Mitchell Gulkis, Robert McKenna, Melike Çağlayan

Nat Commun· July 2022

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