Publications by authors named "Mitchell R Seim"

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Synthesis of 4,5,6,7-tetrahydrothieno[3,2-c]pyridines and comparison with their isosteric 1,2,3,4-tetrahydroisoquinolines as inhibitors of phenylethanolamine N-methyltransferase.
Gary L Grunewald, Mitchell R Seim, Seema R Bhat, Marc E Wilson, Kevin R Criscione

Bioorg Med Chem· January 2008

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Exploring the active site of phenylethanolamine N-methyltransferase with 1,2,3,4-tetrahydrobenz[h]isoquinoline inhibitors.
Gary L Grunewald, Mitchell R Seim, Rachel C Regier, Kevin R Criscione

Bioorg Med Chem· February 2007

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Comparison of the binding of 3-fluoromethyl-7-sulfonyl-1,2,3,4-tetrahydroisoquinolines with their isosteric sulfonamides to the active site of phenylethanolamine N-methyltransferase.
Gary L Grunewald, Mitchell R Seim, Rachel C Regier, Jennifer L Martin, Christine L Gee

J Med Chem· September 2006

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Application of the Goldilocks effect to the design of potent and selective inhibitors of phenylethanolamine N-methyltransferase: balancing pKa and steric effects in the optimization of 3-methyl-1,2,3,4-tetrahydroisoquinoline inhibitors by beta-fluorination.
Gary L Grunewald, Mitchell R Seim, Jian Lu, Mariam Makboul, Kevin R Criscione

J Med Chem· May 2006

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Exploring the active site of phenylethanolamine N-methyltransferase with 3-hydroxyethyl- and 3-hydroxypropyl-7-substituted-1,2,3,4-tetrahydroisoquinolines.
Gary L Grunewald, F Anthony Romero, Mitchell R Seim, Kevin R Criscione, Jean D Deupree

Bioorg Med Chem Lett· February 2005

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