Publications by authors named "Mitchell Weiss"

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A mouse model for hemoglobin SC disease recapitulates characteristic human pathologies.
Jinbin Zhai, James B Papizan, Yu Yao, Elizabeth D Arnold, Jing Yu, Mitchell J Weiss

Blood Adv· December 2025

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Molecular insights into the comorbidity of vitamin K-dependent clotting factor deficiency and chondrodysplasia punctata.
Da-Yun Jin, Xuejie Chen, Mengying Wang, Xiaofeng Qi, Darrel W Stafford, Mitchell J Weiss

J Thromb Haemost· December 2025

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Single-cell transcriptomics reveals heterocellular g-globin gene expression in Agdb-thalassemia.
Phillip A Doerfler, Yichao Li, Yu Yao, Ruopeng Feng, Thiyagaraj Mayuranathan, Mitchell J Weiss

Blood Adv· December 2025

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Increased Prevalence of Clonal Hematopoiesis in Children with Sickle Cell Disease.
Jessica Ulloa, Kristin Wuichet, Sara R Rashkin, Yash Pershad, Connor Shore, Mitchell J Weiss

Blood· December 2025

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A new advance in therapeutic induction of fetal hemoglobin on an uncertain road to durable access.
Deepa Manwani, Sandra Capellera-Garcia, Mitchell J Weiss

Mol Ther· December 2025

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Disrupting epigenetic insulation underlies CRISPR therapy for β-hemoglobinopathies.
Kaili Wang, Juan Wang, Mitchell J Weiss, Feng Yue, Jian Xu

Mol Ther· December 2025

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KDIGO-defined kidney dysfunction predicts long-term outcomes in a multicenter cohort of adults with sickle cell disease.
Xu Zhang, Michael R DeBaun, Kristin Wuichet, Rima Zahr, Zalaya Ivy, Mitchell J Weiss

Blood Adv· November 2025

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Silencing of BCL11A by Disrupting Enhancer-Dependent Epigenetic Insulation.
Kaili Wang, Juan Wang, Ruopeng Feng, Kseniia Dudnyk, Yoon Jung Jung Kim, Mitchell J Weiss

Blood· November 2025

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Transcriptome and chromatin accessibility divergence during differentiation of a bipotential progenitor cell population to erythroblasts and megakaryocytes.
Tejaswini Mishra, Belinda M Giardine, Christapher S Morrissey, Cheryl A Keller, Elisabeth F Heuston, Mitchell J Weiss

J Biol Chem· October 2025

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RPS19 and RPL5 Haploinsufficient Models Reveal Divergent Ribosomal Subunit Controls of Fetal Hematopoiesis.
Lionel Blanc, Yuefeng Tang, Te Ling, Rashid Mehmood, Alexis Bertrand, Mitchell Weiss

Res Sq· September 2025

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Murine hematopoietic progenitor cell lines with erythroid and megakaryocyte potential.
Ruiqiong Wu, Faraz Salehi, Vanessa Redecke, Zhijun Ma, Marco Marchetti, Mitchell J Weiss

Nat Commun· August 2025

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Engraftment and persistence of base-edited hematopoietic stem cells in nonhuman primates.
Stefan Radtke, Emily Fields, Kyle Swing, Greta Kanestrom, Jonathan S Yen, Mitchell J Weiss

Sci Transl Med· August 2025

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Preclinical development of lentiviral vector gene therapy for Diamond-Blackfan anemia syndrome.
Senthil Velan Bhoopalan, Thiyagaraj Mayuranathan, Nana Liu, Kalin Mayberry, Yu Yao, Mitchell J Weiss

Mol Ther· July 2025

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Imbalanced TGFβ signalling and autophagy drive erythroid priming of hematopoietic stem cells in β-thalassemia.
Maria Rosa Lidonnici, Giulia Chianella, Nicole Mende, Hugo P Bastos, Matteo Barcella, Mitchell J Weiss

Nat Commun· July 2025

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Divergence between transcriptomes and chromatin accessibility during differentiation from a bipotential progenitor cell population to erythroblasts and megakaryocytes.
Tejaswini Mishra, Belinda M Giardine, Christapher S Morrissey, Cheryl A Keller, Elisabeth F Heuston, Mitchell J Weiss

bioRxiv· July 2025

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Corrigendum to STAT1 promotes megakaryopoiesis downstream of GATA-1 in mice.
Zan Huang, Terri D Richmond, Andrew G Muntean, Dwayne L Barber, Mitchell J Weiss

J Clin Invest· July 2025

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Removal of promoter CpG methylation by epigenome editing reverses HBG silencing.
Henry W Bell, Ruopeng Feng, Manan Shah, Yu Yao, James Douglas, Mitchell J Weiss

Nat Commun· July 2025

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BCL11A-deficient human erythropoiesis is impaired in vitro and after xenotransplantation into mice.
Yoonjeong Jang, Ruopeng Feng, Lance E Palmer, Thiyagaraj Mayuranathan, Yu Yao, Mitchell J Weiss

Blood Adv· June 2025

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Multiplex base editing to protect from CD33 directed drugs for immune and gene therapy.
Florence Borot, Olivier Humbert, Jeffrey T Ehmsen, Emily Fields, Sajeev Kohli, Mitchell J Weiss

Nat Commun· May 2025

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AMBRA1 performs a balancing act in β-thalassemia.
Christophe Lechauve, Mitchell J Weiss

Blood· March 2025

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A Novel One-Sample Mendelian Randomization Approach for Count-Type Outcomes That Is Robust to Correlated and Uncorrelated Pleiotropic Effects.
Janaka S S Liyanage, Jane S Hankins, Jeremie H Estepp, Deokumar Srivastava, Sara R Rashkin, Mitchell J Weiss

Genet Epidemiol· January 2025

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A glutamine metabolic switch supports erythropoiesis.
Junhua Lyu, Zhimin Gu, Yuannyu Zhang, Hieu S Vu, Christophe Lechauve, Mitchell J Weiss

Science· November 2024

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Development and IND-enabling studies of a novel Cas9 genome-edited autologous CD34 cell therapy to induce fetal hemoglobin for sickle cell disease.
Varun Katta, Kiera O'Keefe, Yichao Li, Thiyagaraj Mayuranathan, Cicera R Lazzarotto, Mitchell J Weiss

Mol Ther· October 2024

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Hydroxyurea reduces the levels of the fetal gene repressors ZBTB7A/LRF and BCL11A in erythroid cells .
Gabriella E Martyn, Phillip A Doerfler, Yu Yao, Kate G R Quinlan, Mitchell J Weiss

J Sick Cell Dis· October 2024

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Interspecies regulatory landscapes and elements revealed by novel joint systematic integration of human and mouse blood cell epigenomes.
Guanjue Xiang, Xi He, Belinda M Giardine, Kathryn J Isaac, Dylan J Taylor, Mitchell J Weiss

Genome Res· August 2024

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