Publications by authors named "Mitsuhiro Ino"

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Phase 1 Single Ascending and Multiple Ascending Dose Studies of Phosphodiesterase-9 Inhibitor E2027: Confirmation of Target Engagement and Selection of Phase 2 Dose in Dementia With Lewy Bodies Trial.
Ishani S Landry, Jagadeesh Aluri, Edgar Schuck, Mitsuhiro Ino, Kanta Horie

Alzheimer Dis Assoc Disord· August 2022

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Selective corticotropin-releasing factor 1 receptor antagonist E2508 reduces restraint stress-induced defecation and visceral pain in rat models.
Ryota Taguchi, Kodo Shikata, Yoshiaki Furuya, Tetsuya Hirakawa, Mitsuhiro Ino

Psychoneuroendocrinology· January 2017

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Selective corticotropin-releasing factor 1 receptor antagonist E2508 has potent antidepressant-like and anxiolytic-like properties in rodent models.
Ryota Taguchi, Kodo Shikata, Yoshiaki Furuya, Mitsuhiro Ino, Kogyoku Shin

Behav Brain Res· October 2016

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Synthesis and structure-activity relationships of 8-substituted-2-aryl-5-alkylaminoquinolines: Potent, orally active corticotropin-releasing factor-1 receptor antagonists.
Kunitoshi Takeda, Taro Terauchi, Minako Hashizume, Kohdoh Shikata, Ryota Taguchi, Yoshinori Takahashi, Mitsuhiro Ino

Bioorg Med Chem· November 2012

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Design, synthesis, and structure-activity relationships of novel pyrazolo[5,1-b]thiazole derivatives as potent and orally active corticotropin-releasing factor 1 receptor antagonists.
Yoshinori Takahashi, Minako Hashizume, Kogyoku Shin, Taro Terauchi, Kunitoshi Takeda, Mitsuhiro Ino

J Med Chem· October 2012

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Design, synthesis, and structure-activity relationships of a series of 2-Ar-8-methyl-5-alkylaminoquinolines as novel CRF₁ receptor antagonists.
Kunitoshi Takeda, Taro Terauchi, Minako Hashizume, Kogyoku Shin, Mitsuhiro Ino

Bioorg Med Chem Lett· September 2012

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Design, synthesis and structure-activity relationships of 5-alkylaminolquinolines as a novel series of CRF1 receptor antagonists.
Kunitoshi Takeda, Taro Terauchi, Kogyoku Shin, Mitsuhiro Ino, Hisashi Shibata

Bioorg Med Chem Lett· July 2012

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Synthesis and structure-activity relationships of pyrazolo[1,5-a]pyridine derivatives: potent and orally active antagonists of corticotropin-releasing factor 1 receptor.
Yoshinori Takahashi, Shigeki Hibi, Yorihisa Hoshino, Koichi Kikuchi, Kogyoku Shin, Mitsuhiro Ino

J Med Chem· June 2012

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Increased glucose tolerance in N-type Ca2+ channel alpha(1B)-subunit gene-deficient mice.
Eiki Takahashi, Masashi Ito, Norimasa Miyamoto, Takeshi Nagasu, Mitsuhiro Ino

Int J Mol Med· June 2005

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Ataxia and peripheral nerve hypomyelination in ADAM22-deficient mice.
Koji Sagane, Kazuhiro Hayakawa, Junko Kai, Tomoko Hirohashi, Eiki Takahashi, Mitsuhiro Ino

BMC Neurosci· May 2005

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Effect of genetic background on Cav2 channel alpha1 and beta subunit messenger RNA expression in cerebellum of N-type Ca2+ channel alpha1B subunit-deficient mice.
Eiki Takahashi, Mitsuhiro Ino, Takeshi Nagasu

Comp Med· December 2004

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Expression analysis of P/Q-type Ca2+ channel alpha 1A subunit mRNA in olfactory mitral cell in N-type Ca2+ channel alpha 1B subunit gene-deficient mice.
Eiki Takahashi, Mitsuhiro Ino, Norimasa Miyamoto, Takeshi Nagasu

Neurosci Lett· April 2004

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Increased expression of P/Q-type Ca2+ channel alpha1A subunit mRNA in cerebellum of N-type Ca2+ channel alpha1B subunit gene-deficient mice.
Eiki Takahashi, Mitsuhiro Ino, Norimasa Miyamoto, Takeshi Nagasu

Brain Res Mol Brain Res· April 2004

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N-type calcium channel alpha1B subunit (Cav2.2) knock-out mice display hyperactivity and vigilance state differences.
Carsten T Beuckmann, Christopher M Sinton, Norimasa Miyamoto, Mitsuhiro Ino, Masashi Yanagisawa

J Neurosci· July 2003

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Ca(2+) channel alpha(1B) subunit (Ca(V) 2.2) knockout mouse reveals a predominant role of N-type channels in the sympathetic regulation of the circulatory system.
Yasuo Mori, Motohiro Nishida, Shunichi Shimizu, Masakazu Ishii, Takashi Yoshinaga, Mitsuhiro Ino

Trends Cardiovasc Med· August 2002

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