Publications by authors named "Mitsuhiro Machitani"

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Maintenance of R-loop structures by phosphorylated hTERT preserves genome integrity.
Mitsuhiro Machitani, Akira Nomura, Taro Yamashita, Mami Yasukawa, Saori Ueki

Nat Cell Biol· June 2024

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Development of novel monoclonal antibodies against nsp12 of SARS-CoV-2.
Mitsuhiro Machitani, Junko Takei, Mika K Kaneko, Saori Ueki, Hirofumi Ohashi

Virol J· December 2022

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Phosphorylation of hTERT at threonine 249 is a novel tumor biomarker of aggressive cancer with poor prognosis in multiple organs.
Yoko Matsuda, Taro Yamashita, Juanjuan Ye, Mami Yasukawa, Keiko Yamakawa, Mitsuhiro Machitani

J Pathol· June 2022

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The RNA transport factor PHAX is required for proper histone H2AX expression and DNA damage response.
Mitsuhiro Machitani, Ichiro Taniguchi, Asako McCloskey, Tatsuya Suzuki, Mutsuhito Ohno

RNA· November 2020

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RNA-dependent RNA polymerase, RdRP, a promising therapeutic target for cancer and potentially COVID-19.
Mitsuhiro Machitani, Mami Yasukawa, Jotaro Nakashima, Yasuhiro Furuichi, Kenkichi Masutomi

Cancer Sci· November 2020

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CDK1 dependent phosphorylation of hTERT contributes to cancer progression.
Mami Yasukawa, Yoshinari Ando, Taro Yamashita, Yoko Matsuda, Shisako Shoji, Mitsuhiro Machitani

Nat Commun· March 2020

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ARS2 Regulates Nuclear Paraspeckle Formation through 3'-End Processing and Stability of NEAT1 Long Noncoding RNA.
Mitsuhiro Machitani, Ichiro Taniguchi, Mutsuhito Ohno

Mol Cell Biol· January 2020

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Antibodies against adenovirus fiber and penton base proteins inhibit adenovirus vector-mediated transduction in the liver following systemic administration.
Kyoko Tomita, Fuminori Sakurai, Shunsuke Iizuka, Masahisa Hemmi, Keisaku Wakabayashi, Mitsuhiro Machitani

Sci Rep· August 2018

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Suppression of Oncolytic Adenovirus-Mediated Hepatotoxicity by Liver-Specific Inhibition of NF-κB.
Mitsuhiro Machitani, Fuminori Sakurai, Keisaku Wakabayashi, Kosuke Nakatani, Masashi Tachibana

Mol Ther Oncolytics· December 2017

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MicroRNA miR-27 Inhibits Adenovirus Infection by Suppressing the Expression of SNAP25 and TXN2.
Mitsuhiro Machitani, Fuminori Sakurai, Keisaku Wakabayashi, Kosuke Nakatani, Masashi Tachibana

J Virol· June 2017

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[Development of Novel Genetically Engineered Adenoviruses Based on Functional Analyses of Adenovirus-encoded Small RNAs].
Mitsuhiro Machitani

Yakugaku Zasshi· April 2017

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Inhibition of CRISPR/Cas9-Mediated Genome Engineering by a Type I Interferon-Induced Reduction in Guide RNA Expression.
Mitsuhiro Machitani, Fuminori Sakurai, Keisaku Wakabayashi, Kosuke Nakatani, Kazuo Takayama

Biol Pharm Bull· March 2017

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Type I Interferons Impede Short Hairpin RNA-Mediated RNAi via Inhibition of Dicer-Mediated Processing to Small Interfering RNA.
Mitsuhiro Machitani, Fuminori Sakurai, Keisaku Wakabayashi, Kosuke Takayama, Masashi Tachibana

Mol Ther Nucleic Acids· March 2017

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Enhanced Oncolytic Activities of the Telomerase-Specific Replication-Competent Adenovirus Expressing Short-Hairpin RNA against Dicer.
Mitsuhiro Machitani, Fuminori Sakurai, Keisaku Wakabayashi, Masashi Tachibana, Toshiyoshi Fujiwara

Mol Cancer Ther· January 2017

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Dicer functions as an antiviral system against human adenoviruses via cleavage of adenovirus-encoded noncoding RNA.
Mitsuhiro Machitani, Fuminori Sakurai, Keisaku Wakabayashi, Kyoko Tomita, Masashi Tachibana

Sci Rep· June 2016

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Efficient detection of human circulating tumor cells without significant production of false-positive cells by a novel conditionally replicating adenovirus.
Fuminori Sakurai, Nobuhiro Narii, Kyoko Tomita, Shinsaku Togo, Kazuhisa Takahashi, Mitsuhiro Machitani

Mol Ther Methods Clin Dev· March 2016

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A targeted adenovirus vector displaying a human fibronectin type III domain-based monobody in a fiber protein.
Hayato Matsui, Fuminori Sakurai, Kazufumi Katayama, Yasuhiro Abe, Mitsuhiro Machitani

Biomaterials· May 2013

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Development of an adenovirus vector lacking the expression of virus-associated RNAs.
Mitsuhiro Machitani, Kazufumi Katayama, Fuminori Sakurai, Hayato Matsui, Tomoko Yamaguchi

J Control Release· September 2011

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Quantitative analysis of the leaky expression of adenovirus genes in cells transduced with a replication-incompetent adenovirus vector.
Kahori Shimizu, Fuminori Sakurai, Mitsuhiro Machitani, Kazufumi Katayama, Hiroyuki Mizuguchi

Mol Pharm· August 2011

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Adenovirus Vector-Derived VA-RNA-Mediated Innate Immune Responses.
Mitsuhiro Machitani, Tomoko Yamaguchi, Kahori Shimizu, Fuminori Sakurai, Kazufumi Katayama

Pharmaceutics· July 2011

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