Publications by authors named "Modesto Rojas"

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Novel Role of AcylCoA:cholesterol acyltransferase 1 (ACAT1/SOAT1) in Diabetic Retinopathy.
Syed Adeel H Zaidi, Tahira Lemtalsi, Zhimin Xu, Mai Yamamoto, Porsche V Sandow, Modesto A Rojas

bioRxiv· October 2025

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Novel Role of Copper Transporter CTR1 and Therapeutic Potential of Copper Chelators in Retinal Ischemia-Reperfusion Injury.
Mai Yamamoto, Dipankar Ash, Varadarajan Sudhahar, Syed Adeel H Zaidi, Modesto A Rojas

Invest Ophthalmol Vis Sci· September 2025

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Novel Role of Copper Transporter CTR1 and Therapeutic Potential of Copper Chelators in Retinal Ischemia-Reperfusion Injury.
Mai Yamamoto, Dipankar Ash, Varadarajan Sudhahar, Syed Adeel H Zaidi, Modesto A Rojas

bioRxiv· May 2025

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Myeloid ACAT1/SOAT1: a novel regulator of dyslipidemia and retinal neovascularization.
Syed A H Zaidi, Ruth B Caldwell, Modesto A Rojas

NPJ Metab Health Dis· January 2025

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Arginine deprivation/citrulline augmentation with ADI-PEG20 as novel therapy for complications in type 2 diabetes.
Ammar A Abdelrahman, Porsche V Sandow, Jing Wang, Zhimin Xu, Modesto Rojas

Mol Metab· November 2024

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Calbindin 2-specific deletion of arginase 2 preserves visual function after optic nerve crush.
Syed A H Zaidi, Zhimin Xu, Tahira Lemtalsi, Porsche Sandow, Sruthi Athota, Modesto A Rojas

Cell Death Dis· October 2023

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Role of acyl-coenzyme A: cholesterol transferase 1 (ACAT1) in retinal neovascularization.
Syed A H Zaidi, Tahira Lemtalsi, Zhimin Xu, Isabella Santana, Porsche Sandow, Modesto A Rojas

J Neuroinflammation· January 2023

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Targeting proliferative retinopathy: Arginase 1 limits vitreoretinal neovascularization and promotes angiogenic repair.
Abdelrahman Y Fouda, Zhimin Xu, Jutamas Suwanpradid, Modesto Rojas, Esraa Shosha

Cell Death Dis· August 2022

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Investigation of Retinal Metabolic Function in Type 1 Diabetic Akita Mice.
Esraa Shosha, Luke Qin, Tahira Lemtalsi, Syed A H Zaidi, Modesto Rojas

Front Cardiovasc Med· June 2022

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Retinal Neuroprotection From Optic Nerve Trauma by Deletion of Arginase 2.
Zhimin Xu, Abdelrahman Y Fouda, Tahira Lemtalsi, Esraa Shosha, Modesto Rojas

Front Neurosci· December 2018

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Blockade of TREM-1 prevents vitreoretinal neovascularization in mice with oxygen-induced retinopathy.
Modesto A Rojas, Zu T Shen, Ruth B Caldwell, Alexander B Sigalov

Biochim Biophys Acta Mol Basis Dis· September 2018

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Neurofibromin Deficiency Induces Endothelial Cell Proliferation and Retinal Neovascularization.
Hanfang Zhang, Farlyn Z Hudson, Zhimin Xu, Rebekah Tritz, Modesto Rojas

Invest Ophthalmol Vis Sci· May 2018

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Mechanisms of Diabetes-Induced Endothelial Cell Senescence: Role of Arginase 1.
Esraa Shosha, Zhimin Xu, S Priya Narayanan, Tahira Lemtalsi, Abdelrahman Y Fouda, Modesto Rojas

Int J Mol Sci· April 2018

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NOX2-Induced Activation of Arginase and Diabetes-Induced Retinal Endothelial Cell Senescence.
Modesto Rojas, Tahira Lemtalsi, Haroldo A Toque, Zhimin Xu, David Fulton

Antioxidants (Basel)· June 2017

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Arginase 2 promotes neurovascular degeneration during ischemia/reperfusion injury.
Esraa Shosha, Zhimin Xu, Harumasa Yokota, Alan Saul, Modesto Rojas

Cell Death Dis· November 2016

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Arginase 2 deficiency prevents oxidative stress and limits hyperoxia-induced retinal vascular degeneration.
Jutamas Suwanpradid, Modesto Rojas, M Ali Behzadian, R William Caldwell, Ruth B Caldwell

PLoS One· July 2015

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Arginase inhibition enhances angiogenesis in endothelial cells exposed to hypoxia.
Lin Wang, Anil Bhatta, Haroldo A Toque, Modesto Rojas, Lin Yao

Microvasc Res· March 2015

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Requirement of NOX2 expression in both retina and bone marrow for diabetes-induced retinal vascular injury.
Modesto Rojas, Wenbo Zhang, Zhimin Xu, Tahira Lemtalsi, Phillip Chandler

PLoS One· September 2014

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Anti-angiogenic actions of the mangosteen polyphenolic xanthone derivative α-mangostin.
Kanjana Jittiporn, Jutamas Suwanpradid, Chintan Patel, Modesto Rojas, Suwan Thirawarapan

Microvasc Res· May 2014

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Arginase in retinopathy.
S Priya Narayanan, Modesto Rojas, Jutamas Suwanpradid, Haroldo A Toque, R William Caldwell

Prog Retin Eye Res· September 2013

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Arginase 1 mediates increased blood pressure and contributes to vascular endothelial dysfunction in deoxycorticosterone acetate-salt hypertension.
Haroldo A Toque, Kenia P Nunes, Modesto Rojas, Anil Bhatta, Lin Yao

Front Immunol· August 2013

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Arginase as a mediator of diabetic retinopathy.
Chintan Patel, Modesto Rojas, S Priya Narayanan, Wenbo Zhang, Zhimin Xu

Front Immunol· July 2013

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Prevention of diabetes-induced arginase activation and vascular dysfunction by Rho kinase (ROCK) knockout.
Lin Yao, Surabhi Chandra, Haroldo A Toque, Anil Bhatta, Modesto Rojas

Cardiovasc Res· March 2013

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Neuroprotection from retinal ischemia/reperfusion injury by NOX2 NADPH oxidase deletion.
Harumasa Yokota, Subhadra P Narayanan, Wenbo Zhang, Hua Liu, Modesto Rojas

Invest Ophthalmol Vis Sci· October 2011

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Anti-inflammatory therapy for diabetic retinopathy.
Wenbo Zhang, Hua Liu, Modesto Rojas, Robert W Caldwell, Ruth B Caldwell

Immunotherapy· May 2011

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