Publications by authors named "Monique Howard"

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CYpHER: catalytic extracellular targeted protein degradation with high potency and durable effect.
Zachary R Crook, Gregory P Sevilla, Pamela Young, Emily J Girard, Tinh-Doan Phi, Monique L Howard

Nat Commun· October 2024

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CYpHER: Catalytic extracellular targeted protein degradation with high potency and durable effect.
Zachary R Crook, Gregory P Sevilla, Pamela Young, Emily J Girard, Tinh-Doan Phi, Monique Howard

bioRxiv· April 2024

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Anti-PCSK9 antibody pharmacokinetics and low-density lipoprotein-cholesterol pharmacodynamics in nonhuman primates are antigen affinity-dependent and exhibit limited sensitivity to neonatal Fc receptor-binding enhancement.
Kirk R Henne, Brandon Ason, Monique Howard, Wei Wang, Jeonghoon Sun

J Pharmacol Exp Ther· April 2015

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A novel antibody engineering strategy for making monovalent bispecific heterodimeric IgG antibodies by electrostatic steering mechanism.
Zhi Liu, Esther C Leng, Kannan Gunasekaran, Martin Pentony, Min Shen, Monique Howard

J Biol Chem· March 2015

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Asymmetrical Fc engineering greatly enhances antibody-dependent cellular cytotoxicity (ADCC) effector function and stability of the modified antibodies.
Zhi Liu, Kannan Gunasekaran, Wei Wang, Vladimir Razinkov, Laura Sekirov, Monique Howard

J Biol Chem· February 2014

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Mutation of Gtf2ird1 from the Williams-Beuren syndrome critical region results in facial dysplasia, motor dysfunction, and altered vocalisations.
Monique L Howard, Stephen J Palmer, Kylie M Taylor, Geoffrey J Arthurson, Matthew W Spitzer

Neurobiol Dis· March 2012

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Plasma protein binding in drug discovery and development.
Monique L Howard, John J Hill, Gerald R Galluppi, Matthew A McLean

Comb Chem High Throughput Screen· February 2010

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Altered serotonin receptor expression is associated with depression-related behavior in the R6/1 transgenic mouse model of Huntington's disease.
Terence Y C Pang, Xin Du, Michelle S Zajac, Monique L Howard, Anthony J Hannan

Hum Mol Genet· February 2009

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PLC-beta1 knockout mice as a model of disrupted cortical development and plasticity: behavioral endophenotypes and dysregulation of RGS4 gene expression.
Caitlin E McOmish, Emma L Burrows, Monique Howard, Anthony J Hannan

Hippocampus· November 2008

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Sex-specific behavioural effects of environmental enrichment in a transgenic mouse model of amyotrophic lateral sclerosis.
Nathan C Stam, Jess Nithianantharajah, Monique L Howard, Julie D Atkin, Surindar S Cheema

Eur J Neurosci· August 2008

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Downregulation of uPAR confirms link in growth and metastasis of osteosarcoma.
Crispin R Dass, Anne P W Nadesapillai, Daniel Robin, Monique L Howard, Jane L Fisher

Clin Exp Metastasis· October 2006

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Cognitive disorders and neurogenesis deficits in Huntington's disease mice are rescued by fluoxetine.
Helen E Grote, Natalie D Bull, Monique L Howard, Anton van Dellen, Colin Blakemore

Eur J Neurosci· October 2005

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An in vivo model of prostate carcinoma growth and invasion in bone.
Jane L Fisher, Jacqueline F Schmitt, Monique L Howard, P Scott Mackie, Peter F M Choong

Cell Tissue Res· March 2002

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