Publications by authors named "Morag Lewis"

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The importance of accurate phenotyping in large-scale analyses of common disorders such as hearing loss.
Morag A Lewis, Bradley A Schulte, Judy R Dubno, Karen P Steel

Eur J Hum Genet· December 2025

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ClinGen recuration of hearing loss-associated genes demonstrates significant changes in gene-disease validity over time.
Kezang C Tshering, Marina T DiStefano, Andrea M Oza, Pamela Ajuyah, Ryan Webb, Morag A Lewis

Genet Med· October 2025

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Large-scale audiometric phenotyping identifies distinct genes and pathways involved in hearing loss subtypes.
Samah Ahmed, Kenneth I Vaden, Morag A Lewis, Darren Leitao, Karen P Steel

Commun Biol· October 2025

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Genes underlying hereditary hearing impairment in humans and in mice.
Morag A Lewis, Karen P Steel

MicroPubl Biol· September 2025

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A machine-learning-based approach to predict early hallmarks of progressive hearing loss.
Federico Ceriani, Joshua Giles, Neil J Ingham, Jing-Yi Jeng, Morag A Lewis

Hear Res· August 2025

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International Consortium on Ageing-Related Pathologies (ICCARP) Audiovestibular Group: fostering international consensus to refine International Classification of Diseases (ICD-11) codes for hearing loss across the life course.
Dialechti Tsimpida, Michael A Akeroyd, Barry L Bentley, Shuvarthi Bhattacharjee, Michael R Bowl, Morag A Lewis

Geroscience· June 2025

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ClinGen recuration of hearing loss-associated genes demonstrates significant changes in gene-disease validity over time.
Kezang C Tshering, Marina T DiStefano, Andrea M Oza, Pamela Ajuyah, Ryan Webb, Morag A Lewis

Genet Med· May 2025

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Investigating the effects of a cryptic splice site in the En2 splice acceptor sequence used in the IKMC knockout-first alleles.
Prerna Nair, Karen P Steel, Morag A Lewis

Mamm Genome· December 2024

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Two new mouse alleles of Ocm and Slc26a5.
Marìa Lachgar-Ruiz, Neil J Ingham, Elisa Martelletti, Jing Chen, Elysia James, Morag A Lewis

Hear Res· October 2024

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Pathological mechanisms and candidate therapeutic approaches in the hearing loss of mice carrying human MIR96 mutations.
Morag A Lewis, Maria Lachgar-Ruiz, Francesca Di Domenico, Graham Duddy, Jing Chen

Genome Med· October 2024

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A new mutation of Sgms1 causes gradual hearing loss associated with a reduced endocochlear potential.
Jing Chen, Morag A Lewis, Alisa Wai, Lucia Yin, Sally J Dawson

Hear Res· September 2024

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Grxcr1 regulates hair bundle morphogenesis and is required for normal mechanoelectrical transduction in mouse cochlear hair cells.
Beatriz Lorente-Cánovas, Stephanie Eckrich, Morag A Lewis, Stuart L Johnson, Walter Marcotti

PLoS One· July 2024

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Targeted genome editing restores auditory function in adult mice with progressive hearing loss caused by a human microRNA mutation.
Wenliang Zhu, Wan Du, Arun Prabhu Rameshbabu, Ariel Miura Armstrong, Stewart Silver, Morag A Lewis

Sci Transl Med· July 2024

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Accurate phenotypic classification and exome sequencing allow identification of novel genes and variants associated with adult-onset hearing loss.
Morag A Lewis, Jennifer Schulte, Lois Matthews, Kenneth I Vaden, Claire J Steves

PLoS Genet· November 2023

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Targeted genome editing restores auditory function in adult mice with progressive hearing loss caused by a human microRNA mutation.
Wenliang Zhu, Wan Du, Arun Prabhu Rameshbabu, Ariel Miura Armstrong, Stewart Silver, Morag A Lewis

bioRxiv· October 2023

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Insights into the pathophysiology of DFNA44 hearing loss associated with CCDC50 frameshift variants.
María Lachgar-Ruiz, Matías Morín, Elisa Martelletti, Neil J Ingham, Lorenzo Preite, Morag A Lewis

Dis Model Mech· August 2023

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Accurate phenotypic classification and exome sequencing allow identification of novel genes and variants associated with adult-onset hearing loss.
Morag A Lewis, Jennifer Schulte, Lois Matthews, Kenneth I Vaden, Claire J Steves

medRxiv· April 2023

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In-depth genetic and molecular characterization of diaphanous related formin 2 (DIAPH2) and its role in the inner ear.
Chiara Chiereghin, Michela Robusto, Morag A Lewis, Susana Caetano, Valentina Massa

PLoS One· January 2023

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Investigating the characteristics of genes and variants associated with self-reported hearing difficulty in older adults in the UK Biobank.
Morag A Lewis, Bradley A Schulte, Judy R Dubno, Karen P Steel

BMC Biol· June 2022

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Identification and characterisation of spontaneous mutations causing deafness from a targeted knockout programme.
Morag A Lewis, Neil J Ingham, Jing Chen, Selina Pearson, Francesca Di Domenico

BMC Biol· March 2022

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Inner hair cell dysfunction in Klhl18 mutant mice leads to low frequency progressive hearing loss.
Neil J Ingham, Navid Banafshe, Clarisse Panganiban, Julia L Crunden, Jing Chen, Morag A Lewis

PLoS One· November 2021

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Translational and interdisciplinary insights into presbyacusis: A multidimensional disease.
Mark A Eckert, Kelly C Harris, Hainan Lang, Morag A Lewis, Richard A Schmiedt

Hear Res· March 2021

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Hearing impairment due to mutations suggests both loss and gain of function effects.
Morag A Lewis, Francesca Di Domenico, Neil J Ingham, Haydn M Prosser, Karen P Steel

Dis Model Mech· December 2020

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Functional analysis of candidate genes from genome-wide association studies of hearing.
Neil J Ingham, Victoria Rook, Francesca Di Domenico, Elysia James, Morag A Lewis

Hear Res· March 2020

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Mouse screen reveals multiple new genes underlying mouse and human hearing loss.
Neil J Ingham, Selina A Pearson, Valerie E Vancollie, Victoria Rook, Morag A Lewis

PLoS Biol· April 2019

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