Publications by authors named "Moran Sun"

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Scaffold-leaping optimization of naphthoquinone derivatives as ferroptosis inducer against non-small lung cancer.
Hua Yang, Xiaoya Wu, Mengyu Li, Yinuo Wang, Mingmei Guo, Moran Sun

Bioorg Med Chem Lett· December 2025

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Discovery of novel aniline-pyrimidine analogues as orally bioavailable dual VEGFR-2/tubulin inhibitors with potent antitumor and anti-angiogenesis efficacy.
Yanan Chu, Guiyan Huang, Yongfang Yao, Aoyun Wang, Yixin Zhang, Moran Sun

Bioorg Chem· December 2025

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Drug Repurposing of Octreotide as a Selective Apelin Receptor Antagonist Against Pathological Angiogenesis: Integrated Virtual Screening and Zebrafish Validation.
Yongfang Yao, Yinuo Wang, Liping Chen, Mingmei Guo, Hua Yang, Moran Sun

J Ocul Pharmacol Ther· October 2025

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Design, Synthesis and Anti-Inflammation Evaluation of -Acyl Tryptophan Derivatives as Promising P2YR Antagonists Against Lipopolysaccharide-Induced Acute Lung Injury.
Bingqian Han, Shiyu Ma, Wenjin Liu, Yuyang Wang, Mingzhu Wang, Moran Sun

Drug Des Devel Ther· August 2025

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Important Role of Triphenylamine in Modulating the Antibacterial Performance Relationships of Antimicrobial Peptide Mimics by Alkyl Chain Engineering.
Ruirui Li, Moran Sun, Zhi-Hao Li, Ye Qu, Yuanbo Li

J Med Chem· May 2025

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Design, synthesis and biological evaluation of benzo[b]thiophene analogues as novel ferroptosis inhibitor that inhibit fibrosarcoma cell proliferation.
Hua Yang, Mingmei Guo, Sumeng Guan, Yuanyuan Chang, Xiaoya Wu, Moran Sun

Bioorg Med Chem· April 2025

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Synthesis and biological evaluation of 4-phenyl-5-quinolinyl substituted isoxazole analogues as potent cytotoxic and tubulin polymerization inhibitors against ESCC.
Meiqi Jia, Yuanyuan Pei, Na Li, Ying Zhang, Jian Song, Moran Sun

Eur J Med Chem· September 2024

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Discovery of N-Substituted Acetamide Derivatives as Promising P2YR Antagonists Using Molecular Hybridization Based on Crystallographic Overlay.
Wenjin Liu, Shuqiang Mao, Yuyang Wang, Mingzhu Wang, Mengyu Li, Moran Sun

J Med Chem· June 2024

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Discovery of the 2,4-disubstituted quinazoline derivative as a novel neddylation inhibitor for tumor therapy.
Jingtian Su, Mengyu Li, Yuanyuan Chang, Meiqi Jia, Mei Zhao, Moran Sun

Bioorg Chem· April 2024

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Identification of novel benzothiazole derivatives as inhibitors of NEDDylation pathway to inhibit the progression of gastric cancer.
Xuan Wang, Mei Zhao, Yuanyuan Chang, Sumeng Guan, Mengyu Li, Moran Sun

Bioorg Med Chem Lett· March 2024

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Discovery of the cereblon-recruiting tubulin PROTACs effective in overcoming Taxol resistance in vitro and in vivo.
Hua Yang, Jinling Qin, Yuanyuan Pei, Sumeng Guan, Mei Zhao, Moran Sun

Eur J Med Chem· February 2024

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Discovery of N-(2-oxoethyl) sulfanilamide-derived inhibitors of KAT6A (MOZ) against leukemia by an isostere strategy.
Yongtao Duan, Yabiao Zhao, Zhenzhen Li, Zhenling Liu, Mingzhu Wang, Moran Sun

Eur J Med Chem· November 2023

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Design, synthesis and biological evaluation of novel tubulin inhibitors targeting colchicine sites.
Minghua Yuan, Jingtian Su, Yixin Zhang, Jinling Qin, Hua Yang, Moran Sun

Bioorg Med Chem Lett· March 2023

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Design, synthesis, and biological activity evaluation of novel tubulin polymerization inhibitors based on pyrimidine ring skeletons.
Yingying Kang, Yuanyuan Pei, Jinling Qin, Yixin Zhang, Yongtao Duan, Moran Sun

Bioorg Med Chem Lett· March 2023

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Identification of novel non-toxic and anti-angiogenic α-fluorinated chalcones as potent colchicine binding site inhibitors.
Moran Sun, Minghua Yuan, Yingying Kang, Jinling Qin, Yixin Zhang

J Enzyme Inhib Med Chem· December 2022

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Discovery of a novel piperlongumine analogue as a microtubule polymerization inhibitor with potent anti-angiogenic and anti-metastatic efficacy.
Jinling Qin, Hongliang Li, Xuan Wang, Yixin Zhang, Yongtao Duan, Moran Sun

Eur J Med Chem· December 2022

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APJ/apelin: A promising target for the treatment of retinopathy of prematurity.
Jingtian Su, Yixin Zhang, Senthil Arun Kumar, Moran Sun, Yongfang Yao

Drug Discov Today· August 2022

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2-Methoxydiol derivatives as new tubulin and HDAC dual-targeting inhibitors, displaying antitumor and antiangiogenic response.
Moran Sun, Jinling Qin, Yingying Kang, Yixin Zhang, Mengyu Ba

Bioorg Chem· March 2022

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Discovery of novel tubulin/HDAC dual-targeting inhibitors with strong antitumor and antiangiogenic potency.
Yingge Wang, Moran Sun, Yuyang Wang, Jinling Qin, Yixin Zhang

Eur J Med Chem· December 2021

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The role of MOZ/KAT6A in hematological malignancies and advances in MOZ/KAT6A inhibitors.
Jingtian Su, Xuan Wang, Yuwei Bai, Moran Sun, Yongfang Yao

Pharmacol Res· December 2021

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Angiogenesis, Anti-Tumor, and Anti-Metastatic Activity of Novel α-Substituted Hetero-Aromatic Chalcone Hybrids as Inhibitors of Microtubule Polymerization.
Moran Sun, Yuyang Wang, Minghua Yuan, Qing Zhao, Yixin Zhang

Front Chem· November 2021

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Synthesis and biological evaluation of new 2-methoxyestradiol derivatives: Potent inhibitors of angiogenesis and tubulin polymerization.
Moran Sun, Yixin Zhang, Jinling Qin, Mengyu Ba, Yongfang Yao

Bioorg Chem· August 2021

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Cyclopropyl Scaffold: A Generalist for Marketed Drugs.
Mo-Ran Sun, Hong-Liang Li, Meng-Yu Ba, Weyland Cheng, Hai-Liang Zhu

Mini Rev Med Chem· July 2021

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Concise synthesis of 2-methoxyestradiol through C(sp)-H methoxylation.
Mo-Ran Sun, Ying-Ying Kang, Yong-Tao Duan, Hong-Min Liu

Steroids· October 2020

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Triazol: a privileged scaffold for proteolysis targeting chimeras.
Li-Wen Xia, Meng-Yu Ba, Wei Liu, Weyland Cheng, Chao-Ping Hu, Mo-Ran Sun

Future Med Chem· November 2019

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