Publications by authors named "Motlik Jan"

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Restored phagocytic ability of RPE patches derived from gene-corrected retinitis pigmentosa-hiPSCs on a biodegradable scaffold via clinical-grade protocol: Implications for autologous therapy.
Rodriguez-Jimenez Francisco Javier, Artero-Castro Ana, Studenovska Hana, Selles Francisca, Arteaga Claramunt Alba Maria, Motlik Jan

Genes Dis· November 2025

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Subretinal Injection Volume Correlates to Persistent Outer Retinal Thinning in the Pig Eye.
Immanuel P Seitz, Ruslan Nyshchuk, Zdenka Ellederova, Taras Ardan, Jana Juhasova, Jan Motlik

Invest Ophthalmol Vis Sci· November 2025

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A model for de novo pigmentation of amelanotic retinal pigment epithelial cells.
Santosh Gupta, Lyubomyr Lytvynchuk, Taras Ardan, Hana Studenovska, Georgina Faura, Jan Motlik

Acta Ophthalmol· September 2025

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Delivery of Human iPSC-Derived RPE Cells in Healthy Minipig Retina Results in Interaction Between Photoreceptors and Transplanted Cells.
Anna Macečková Brymová, Francisco Javier Rodriguez-Jimenez, Annika Konrad, Yaroslav Nemesh, Muhammed Arshad Thottappali, Jana Juhasova, Jan Motlik

Adv Sci (Weinh)· May 2025

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Safety of Human USH1C Transgene Expression Following Subretinal Injection in Wild-Type Pigs.
Peter Kiraly, Joshua Klein, Immanuel P Seitz, Felix F Reichel, Tobias Peters, Jana Juhasova, Jan Motlik

Invest Ophthalmol Vis Sci· January 2025

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Optimizing Subretinal Bleb Formation for Visual Streak Involvement in a Porcine Model for Retinal Gene Therapy.
Immanuel P Seitz, Tobias Peters, Felix Reichel, Andrea Bähr, Hanna Auch, Jan Motlik, Jana Juhasova

Invest Ophthalmol Vis Sci· October 2024

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Feasibility of Direct Vitrectomy-Sparing Subretinal Injection for Gene Delivery in Large Animals.
Zbynek Stranak, Taras Ardan, Yaroslav Nemesh, Maria Toms, Lyes Toualbi, Jan Motlik

Curr Eye Res· August 2024

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Progress in Stem Cells-Based Replacement Therapy for Retinal Pigment Epithelium: In Vitro Differentiation to In Vivo Delivery.
Santosh Gupta, Lyubomyr Lytvynchuk, Taras Ardan, Hana Studenovska, Ruchi Sharma, Jan Motlik

Stem Cells Transl Med· August 2023

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Rapid and Reliable Quantification of Prime Editing Targeting Within the Porcine Gene Using a BRET-Based Sensor.
Tobias Wimmer, Hannah Sawinski, Anne M Urban, Jan Motlik, Knut Stieger

Nucleic Acid Ther· June 2023

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Retinal Pigment Epithelium Cell Development: Extrapolating Basic Biology to Stem Cell Research.
Santosh Gupta, Lyubomyr Lytvynchuk, Taras Ardan, Hana Studenovska, Georgina Faura, Jan Motlik

Biomedicines· January 2023

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Subretinal Implantation of RPE on a Carrier in Minipigs: Guidelines for Preoperative Preparations, Surgical Techniques, and Postoperative Care.
Lyubomyr Lytvynchuk, Zbynek Stranak, Hana Studenovska, David Rais, Štěpán Popelka, Jana Čížková, Jana Juhásová, Jan Motlik

J Vis Exp· November 2022

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Mitochondrial Dysfunction in a High Intraocular Pressure-Induced Retinal Ischemia Minipig Model.
Michael Pasák, Marie Vanišová, Lucie Tichotová, Jana Křížová, Taras Ardan, Jana Čížková, Jan Motlík

Biomolecules· October 2022

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Advantages of nanofibrous membranes for culturing of primary RPE cells compared to commercial scaffolds.
Lucie Tichotová, Hana Studenovska, Goran Petrovski, Štěpán Popelka, Yaroslav Nemesh, Jan Motlík

Acta Ophthalmol· August 2022

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Precision spinal gene delivery-induced functional switch in nociceptive neurons reverses neuropathic pain.
Takahiro Tadokoro, Mariana Bravo-Hernandez, Kirill Agashkov, Yoshiomi Kobayashi, Oleksandr Platoshyn, Jana Juhasova, Jan Motlik

Mol Ther· August 2022

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Early disruption of photoreceptor cell architecture and loss of vision in a humanized pig model of usher syndromes.
Sophia Grotz, Jessica Schäfer, Kirsten A Wunderlich, Zdenka Ellederova, Hannah Auch, Janet Fadl, Jan Motlik

EMBO Mol Med· April 2022

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Subretinal Implantation of Human Primary RPE Cells Cultured on Nanofibrous Membranes in Minipigs.
Lyubomyr Lytvynchuk, Annabelle Ebbert, Hana Studenovska, Richárd Nagymihály, Natasha Josifovska, Jana Čížková, Jana Juhásová, Janka Franeková, Jan Motlík

Biomedicines· March 2022

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Targeted mass spectrometry for monitoring of neural differentiation.
Rita Sucha, Martina Kubickova, Jakub Cervenka, Marian Hruska-Plochan, Dasa Bohaciakova, Jan Motlik

Biol Open· August 2021

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Widespread and sustained target engagement in Huntington's disease minipigs upon intrastriatal microRNA-based gene therapy.
Astrid Vallès, Melvin M Evers, Anouk Stam, Marina Sogorb-Gonzalez, Cynthia Brouwers, Jan Motlik

Sci Transl Med· April 2021

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Age-Related Oxidative Changes in Primary Porcine Fibroblasts Expressing Mutated Huntingtin.
Petra Smatlikova, Georgina Askeland, Michaela Vaskovicova, Jiri Klima, Jan Motlik

Neurodegener Dis· August 2020

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Adipogenic Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells in Pig Transgenic Model Expressing Human Mutant Huntingtin.
Petra Smatlikova, Stefan Juhas, Jana Juhasova, Tomas Suchy, Marie Hubalek Kalbacova, Jan Motlik

J Huntingtons Dis· March 2020

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Transgenic minipig model of Huntington's disease exhibiting gradually progressing neurodegeneration.
Taras Ardan, Monika Baxa, Božena Levinská, Miroslava Sedláčková, The Duong Nguyen, Jana Juhásová, Jan Motlík

Dis Model Mech· December 2019

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Development of an AAV-Based MicroRNA Gene Therapy to Treat Machado-Joseph Disease.
Raygene Martier, Marina Sogorb-Gonzalez, Janice Stricker-Shaver, Jeannette Hübener-Schmid, Sonay Keskin, Jana Juhasova, Jan Motlik

Mol Ther Methods Clin Dev· December 2019

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Serum proteomic analysis of melanoma patients with immunohistochemical profiling of primary melanomas and cultured cells: Pilot study.
Jan Kučera, Karolína Strnadová, Barbora Dvořánková, Lukáš Lacina, Ivana Krajsová, Jan Motlík

Oncol Rep· November 2019

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Deterioration of mitochondrial bioenergetics and ultrastructure impairment in skeletal muscle of a transgenic minipig model in the early stages of Huntington's disease.
Marie Rodinova, Jana Krizova, Hana Stufkova, Bozena Bohuslavova, Georgina Askeland, Jana Juhasova, Jan Motlik

Dis Model Mech· July 2019

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The identification of small molecules that stimulate retinal pigment epithelial cells: potential novel therapeutic options for treating retinopathies.
Ana Artero-Castro, Stepan Popelka, Pavla Jendelova, Jan Motlik, Taras Ardan

Expert Opin Drug Discov· February 2019

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