Publications by authors named "Motoharu Awazawa"

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Activin B improves glucose metabolism via induction of Fgf21 and hepatic glucagon resistance.
Naoki Kobayashi, Yukiko Okazaki, Aya Iwane, Kazuo Hara, Momoko Horikoshi, Motoharu Awazawa

Nat Commun· April 2025

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Corrigendum to "Imeglimin improves systemic metabolism by targeting brown adipose tissue and gut microbiota in obese model mice" [Metabolism 153 (April 2024) 155796].
Motoharu Awazawa, Maya Matsushita, Ikumi Nomura, Naoki Kobayashi, Miwa Tamura-Nakano

Metabolism· June 2024

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Imeglimin improves systemic metabolism by targeting brown adipose tissue and gut microbiota in obese model mice.
Motoharu Awazawa, Maya Matsushita, Ikumi Nomura, Naoki Kobayashi, Miwa Tamura-Nakano

Metabolism· April 2024

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Gut insulin action protects from hepatocarcinogenesis in diabetic mice comorbid with nonalcoholic steatohepatitis.
Kotaro Soeda, Takayoshi Sasako, Kenichiro Enooku, Naoto Kubota, Naoki Kobayashi, Motoharu Awazawa

Nat Commun· October 2023

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An antisense transcript transcribed from Irs2 locus contributes to the pathogenesis of hepatic steatosis in insulin resistance.
Maya Matsushita, Motoharu Awazawa, Naoki Kobayashi, Yoshiko Matsumoto Ikushima, Kotaro Soeda

Cell Chem Biol· April 2022

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Exploring regulatory network of metabolism through liver research.
Motoharu Awazawa

Diabetol Int· October 2021

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MEK/ERK Signaling in β-Cells Bifunctionally Regulates β-Cell Mass and Glucose-Stimulated Insulin Secretion Response to Maintain Glucose Homeostasis.
Yoshiko Matsumoto Ikushima, Motoharu Awazawa, Naoki Kobayashi, Sho Osonoi, Seiichi Takemiya

Diabetes· July 2021

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A MAFG-lncRNA axis links systemic nutrient abundance to hepatic glucose metabolism.
Marta Pradas-Juni, Nils R Hansmeier, Jenny C Link, Elena Schmidt, Bjørk Ditlev Larsen, Motoharu Awazawa

Nat Commun· January 2020

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CerS6-Derived Sphingolipids Interact with Mff and Promote Mitochondrial Fragmentation in Obesity.
Philipp Hammerschmidt, Daniela Ostkotte, Hendrik Nolte, Mathias J Gerl, Alexander Jais, Motoharu Awazawa

Cell· May 2019

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CerS1-Derived C Ceramide in Skeletal Muscle Promotes Obesity-Induced Insulin Resistance.
Sarah M Turpin-Nolan, Philipp Hammerschmidt, Weiyi Chen, Alexander Jais, Katharina Timper, Motoharu Awazawa

Cell Rep· January 2019

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Acquired partial lipoatrophy as graft-versus-host disease and treatment with metreleptin: two case reports.
Yusuke Shibata, Atsuko Nakatsuka, Jun Eguchi, Satoshi Miyamoto, Yukari Masuda, Motoharu Awazawa

J Med Case Rep· December 2018

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Food Perception Primes Hepatic ER Homeostasis via Melanocortin-Dependent Control of mTOR Activation.
Claus Brandt, Hendrik Nolte, Sinika Henschke, Linda Engström Ruud, Motoharu Awazawa

Cell· November 2018

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LincRNA H19 protects from dietary obesity by constraining expression of monoallelic genes in brown fat.
Elena Schmidt, Ines Dhaouadi, Isabella Gaziano, Matteo Oliverio, Paul Klemm, Motoharu Awazawa

Nat Commun· September 2018

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The RNA Methyltransferase Complex of WTAP, METTL3, and METTL14 Regulates Mitotic Clonal Expansion in Adipogenesis.
Masatoshi Kobayashi, Mitsuru Ohsugi, Takayoshi Sasako, Motoharu Awazawa, Toshihiro Umehara

Mol Cell Biol· August 2018

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A microRNA screen reveals that elevated hepatic ectodysplasin A expression contributes to obesity-induced insulin resistance in skeletal muscle.
Motoharu Awazawa, Paula Gabel, Eva Tsaousidou, Hendrik Nolte, Marcus Krüger

Nat Med· December 2017

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Deregulation of pancreas-specific oxidoreductin ERO1β in the pathogenesis of diabetes mellitus.
Motoharu Awazawa, Takashi Futami, Michinori Sakada, Kazuma Kaneko, Mitsuru Ohsugi

Mol Cell Biol· April 2014

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Neonatal insulin action impairs hypothalamic neurocircuit formation in response to maternal high-fat feeding.
Merly C Vogt, Lars Paeger, Simon Hess, Sophie M Steculorum, Motoharu Awazawa

Cell· January 2014

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Blockade of class IB phosphoinositide-3 kinase ameliorates obesity-induced inflammation and insulin resistance.
Naoki Kobayashi, Kohjiro Ueki, Yukiko Okazaki, Aya Iwane, Naoto Kubota, Motoharu Awazawa

Proc Natl Acad Sci U S A· April 2011

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Adiponectin enhances insulin sensitivity by increasing hepatic IRS-2 expression via a macrophage-derived IL-6-dependent pathway.
Motoharu Awazawa, Kohjiro Ueki, Kazunori Inabe, Toshimasa Yamauchi, Naoto Kubota

Cell Metab· April 2011

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Class IA phosphatidylinositol 3-kinase in pancreatic β cells controls insulin secretion by multiple mechanisms.
Kazuma Kaneko, Kohjiro Ueki, Noriko Takahashi, Shinji Hashimoto, Masayuki Okamoto, Motoharu Awazawa

Cell Metab· December 2010

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Adiponectin suppresses hepatic SREBP1c expression in an AdipoR1/LKB1/AMPK dependent pathway.
Motoharu Awazawa, Kohjiro Ueki, Kazunori Inabe, Toshimasa Yamauchi, Kazuma Kaneko

Biochem Biophys Res Commun· April 2009

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Rimonabant ameliorates insulin resistance via both adiponectin-dependent and adiponectin-independent pathways.
Taku Watanabe, Naoto Kubota, Mitsuru Ohsugi, Tetsuya Kubota, Iseki Takamoto, Motoharu Awazawa

J Biol Chem· January 2009

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Molecular mechanism of moderate insulin resistance in adiponectin-knockout mice.
Wataru Yano, Naoto Kubota, Shinsuke Itoh, Tetsuya Kubota, Motoharu Awazawa

Endocr J· July 2008

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Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions.
Toshimasa Yamauchi, Yasunori Nio, Toshiyuki Maki, Masaki Kobayashi, Takeshi Takazawa, Motoharu Awazawa

Nat Med· March 2007

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[Not Available].
Motoharu Awazawa, Mitsuhiko Noda, Takashi Kadowaki

Clin Calcium· August 2003

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