Publications by authors named "Muhammad Jbara"

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Chemical Engineering of Transcription Factors Uncovered Cell-Permeable μMax Modulators.
Omer Harel, Ferran Nadal-Bufi, Raj V Nithun, Yumi Minyi Yao, Ariel Afek, Muhammad Jbara

J Am Chem Soc· November 2025

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Deciphering the dynamic code: DNA recognition by transcription factors in the ever-changing genome.
Yumi Minyi Yao, Irina Miodownik, Michael P O'Hagan, Muhammad Jbara, Ariel Afek

Transcription· April 2025

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One-Pot Total Synthesis of a Post-translationally Modified Max Transcription Factor Sheds Light on Ser-Phosphorylation and Lys-Acetylation Crosstalk in DNA Binding.
Raj V Nithun, Shada Khoury, Muhammad Jbara

Org Lett· April 2025

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Unprecedented Photoinduced-Electron-Transfer Probe with a Turn-ON Chemiluminescence Mode-of-Action.
Maya David, Sara Gutkin, Raj V Nithun, Muhammad Jbara, Doron Shabat

Angew Chem Int Ed Engl· February 2025

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Late-Stage Minimal Labeling of Peptides and Proteins for Real-Time Imaging of Cellular Trafficking.
Ferran Nadal-Bufi, Raj V Nithun, Fabio de Moliner, Xiaoxi Lin, Shaimaa Habiballah, Muhammad Jbara

ACS Cent Sci· January 2025

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A Versatile Method for Site-Specific Chemical Installation of Aromatic Posttranslational Modification Analogs into Proteins.
Xiaoxi Lin, Shaswati Mandal, Raj V Nithun, Rajasekhar Kolla, Bouchra Bouri, Muhammad Jbara

J Am Chem Soc· September 2024

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Site-Specific Acetylation of the Transcription Factor Protein Max Modulates Its DNA Binding Activity.
Raj V Nithun, Yumi Minyi Yao, Omer Harel, Shaimaa Habiballah, Ariel Afek, Muhammad Jbara

ACS Cent Sci· June 2024

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Chemical Engineering of Artificial Transcription Factors by Orthogonal Palladium(II)-Mediated S-Arylation Reactions.
Xiaoxi Lin, Omer Harel, Muhammad Jbara

Angew Chem Int Ed Engl· January 2024

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Deciphering the Role of the Ser-Phosphorylation Pattern on the DNA-Binding Activity of Max Transcription Factor Using Chemical Protein Synthesis.
Raj V Nithun, Yumi Minyi Yao, Xiaoxi Lin, Shaimaa Habiballah, Ariel Afek, Muhammad Jbara

Angew Chem Int Ed Engl· November 2023

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Histone H3 serine-57 is a CHK1 substrate whose phosphorylation affects DNA repair.
Nikolaos Parisis, Pablo D Dans, Muhammad Jbara, Balveer Singh, Diane Schausi-Tiffoche

Nat Commun· August 2023

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Enabling Peptide Ligation at Aromatic Junction Mimics via Native Chemical Ligation and Palladium-Mediated S-Arylation.
Xiaoxi Lin, Raj V Nithun, Raju Samanta, Omer Harel, Muhammad Jbara

Org Lett· June 2023

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Chemical Synthesis of Bioactive Proteins.
Omer Harel, Muhammad Jbara

Angew Chem Int Ed Engl· March 2023

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Posttranslational Chemical Mutagenesis Methods to Insert Posttranslational Modifications into Recombinant Proteins.
Omer Harel, Muhammad Jbara

Molecules· July 2022

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Engineering Bioactive Dimeric Transcription Factor Analogs via Palladium Rebound Reagents.
Muhammad Jbara, Sebastian Pomplun, Carly K Schissel, Susana Wilson Hawken, Ann Boija

J Am Chem Soc· August 2021

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Parallel Automated Flow Synthesis of Covalent Protein Complexes That Can Inhibit MYC-Driven Transcription.
Sebastian Pomplun, Muhammad Jbara, Carly K Schissel, Susana Wilson Hawken, Ann Boija

ACS Cent Sci· August 2021

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Oligonucleotide Bioconjugation with Bifunctional Palladium Reagents.
Muhammad Jbara, Jacob Rodriguez, Heemal H Dhanjee, Andrei Loas, Stephen L Buchwald

Angew Chem Int Ed Engl· May 2021

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Discovery of High-Affinity Peptide Binders for the SARS-CoV-2 Spike Protein.
Sebastian Pomplun, Muhammad Jbara, Anthony J Quartararo, Genwei Zhang, Joseph S Brown

ACS Cent Sci· January 2021

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Gold(I)-Mediated Decaging or Cleavage of Propargylated Peptide Bond in Aqueous Conditions for Protein Synthesis and Manipulation.
Muhammad Jbara, Emad Eid, Ashraf Brik

J Am Chem Soc· May 2020

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Semisynthesis of ubiquitinated histone H2B with a native or nonhydrolyzable linkage.
Michael Morgan, Muhammad Jbara, Ashraf Brik, Cynthia Wolberger

Methods Enzymol· November 2019

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FACT and Ubp10 collaborate to modulate H2B deubiquitination and nucleosome dynamics.
Melesse Nune, Michael T Morgan, Zaily Connell, Laura McCullough, Muhammad Jbara

Elife· January 2019

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Chemical chromatin ubiquitylation.
Muhammad Jbara, Hao Sun, Guy Kamnesky, Ashraf Brik

Curr Opin Chem Biol· August 2018

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Palladium prompted on-demand cysteine chemistry for the synthesis of challenging and uniquely modified proteins.
Muhammad Jbara, Shay Laps, Michael Morgan, Guy Kamnesky, Guy Mann

Nat Commun· August 2018

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Palladium mediated deallylation in fully aqueous conditions for native chemical ligation at aspartic and glutamic acid sites.
Muhammad Jbara, Emad Eid, Ashraf Brik

Org Biomol Chem· June 2018

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Total chemical synthesis of histones and their analogs, assisted by native chemical ligation and palladium complexes.
Suman Kumar Maity, Muhammad Jbara, Guy Mann, Guy Kamnesky, Ashraf Brik

Nat Protoc· November 2017

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Total chemical synthesis of methylated analogues of histone 3 revealed KDM4D as a potential regulator of H3K79me3.
Muhammad Jbara, Noga Guttmann-Raviv, Suman Kumar Maity, Nabieh Ayoub, Ashraf Brik

Bioorg Med Chem· September 2017

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