Publications by authors named "Muhammad Rafehi"

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Cooperativity between endogenous glutamylcysteinylglycine-based oligopeptides and drugs determines the function of the multidrug transporter ABCC1.
Katja Stefan, Muhammad Rafehi, Hauke Busch, Vigneshwaran Namasivayam, Sven Marcel Stefan

Biochem Pharmacol· December 2025

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Polypharmacology translates between species and phylogenetic distance: A functional, bioinformatic, and structural study on organic anion transporting polypeptides.
Katja Stefan, Vigneshwaran Namasivayam, Mst Tazmin Akhter, Gergely Gyimesi, Muhammad Rafehi

Biochem Pharmacol· September 2025

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Transport of Small Aliphatic Amines by Polyspecific Solute Carriers: Deciphering Structure-Function Relationships.
Wouroud Ismail Al-Khalil, Jürgen Brockmöller, Muhammad Rafehi

ACS Pharmacol Transl Sci· August 2025

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Functional and structural polypharmacology of indazole-based privileged ligands to tackle the undruggability of membrane transporters.
Katja Stefan, Sachin Puri, Muhammad Rafehi, Ganesh Latambale, Maria Neif

Eur J Med Chem· April 2025

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The Necessity for Polypharmacological Research - An Editorial on 'Network Polypharmacology of ATP-binding Cassette (ABC) and Solute Carrier (SLC) Transporters'.
Muhammad Rafehi, Kapil Juvale, Lukasz Pulaski, Sven Marcel Stefan

Front Pharmacol· March 2025

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Target repurposing unravels avermectins and derivatives as novel antibiotics inhibiting energy-coupling factor transporters (ECFTs).
Jörg Haupenthal, Muhammad Rafehi, Andreas M Kany, Anne Lespine, Katja Stefan

Arch Pharm (Weinheim)· September 2024

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The big data challenge - and how polypharmacology supports the translation from pre-clinical research into clinical use against neurodegenerative diseases and beyond.
Sven Marcel Stefan, Muhammad Rafehi

Neural Regen Res· August 2024

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Medicinal polypharmacology-a scientific glossary of terminology and concepts.
Sven Marcel Stefan, Muhammad Rafehi

Front Pharmacol· July 2024

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Medicinal Polypharmacology in the Clinic - Translating the Polypharmacolome into Therapeutic Benefit.
Muhammad Rafehi, Marius Möller, Wouroud Ismail Al-Khalil, Sven Marcel Stefan

Pharm Res· March 2024

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Medicinal polypharmacology: Exploration and exploitation of the polypharmacolome in modern drug development.
Sven Marcel Stefan, Muhammad Rafehi

Drug Dev Res· February 2024

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Stereoselective Inhibition of High- and Low-Affinity Organic Cation Transporters.
Lukas Gebauer, Ole Jensen, Muhammad Rafehi, Jürgen Brockmöller

Mol Pharm· December 2023

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Stereoselectivity in Cell Uptake by SLC22 Organic Cation Transporters 1, 2, and 3.
Lukas Gebauer, Ole Jensen, Muhammad Rafehi, Jürgen Brockmöller

J Med Chem· December 2023

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A Novel Huntington's Disease Assessment Platform to Support Future Drug Discovery and Development.
Jingyun Wu, Luisa Möhle, Thomas Brüning, Iván Eiriz, Muhammad Rafehi

Int J Mol Sci· November 2022

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Stereoselectivity in the Membrane Transport of Phenylethylamine Derivatives by Human Monoamine Transporters and Organic Cation Transporters 1, 2, and 3.
Lukas Gebauer, Muhammad Rafehi, Jürgen Brockmöller

Biomolecules· October 2022

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Molecular basis for stereoselective transport of fenoterol by the organic cation transporters 1 and 2.
Lukas Gebauer, N Arul Murugan, Ole Jensen, Jürgen Brockmöller, Muhammad Rafehi

Biochem Pharmacol· March 2022

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Thermal proteome profiling identifies the membrane-bound purinergic receptor P2X4 as a target of the autophagy inhibitor indophagolin.
Marjorie A Carnero Corrales, Sarah Zinken, Georgios Konstantinidis, Muhammad Rafehi, Aliaa Abdelrahman

Cell Chem Biol· December 2021

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Unraveling binding mechanism and kinetics of macrocyclic Gα protein inhibitors.
Jan H Voss, Jessica Nagel, Muhammad Rafehi, Ramon Guixà-González, Davide Malfacini

Pharmacol Res· November 2021

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Effects of Genetic Polymorphism in CYP2D6, CYP2C19, and the Organic Cation Transporter OCT1 on Amitriptyline Pharmacokinetics in Healthy Volunteers and Depressive Disorder Patients.
Johannes Matthaei, Jürgen Brockmöller, Werner Steimer, Konstanze Pischa, Stefan Leucht, Muhammad Rafehi

Front Pharmacol· May 2021

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Cellular Uptake of Psychostimulants - Are High- and Low-Affinity Organic Cation Transporters Drug Traffickers?
Ole Jensen, Muhammad Rafehi, Lukas Gebauer, Jürgen Brockmöller

Front Pharmacol· January 2021

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Cell-permeable high-affinity tracers for G proteins provide structural insights, reveal distinct binding kinetics and identify small molecule inhibitors.
Markus Kuschak, Vigneshwaran Namasivayam, Muhammad Rafehi, Jan H Voss, Jaspal Garg

Br J Pharmacol· April 2020

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Ligand binding and activation of UTP-activated G protein-coupled P2Y and P2Y receptors elucidated by mutagenesis, pharmacological and computational studies.
Isaac Y Attah, Alexander Neumann, Haneen Al-Hroub, Muhammad Rafehi, Younis Baqi

Biochim Biophys Acta Gen Subj· March 2020

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Stereoselective cell uptake of adrenergic agonists and antagonists by organic cation transporters.
Ole Jensen, Muhammad Rafehi, Mladen V Tzvetkov, Jürgen Brockmöller

Biochem Pharmacol· January 2020

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Adenine-(methoxy)-ethoxy-P-dithio-triphosphate inhibits pathologic calcium pyrophosphate deposition in osteoarthritic human chondrocytes.
Molhm Nassir, Salahuddin Mirza, Uri Arad, Sangyong Lee, Muhammad Rafehi

Org Biomol Chem· November 2019

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Highly Variable Pharmacokinetics of Tyramine in Humans and Polymorphisms in OCT1, CYP2D6, and MAO-A.
Muhammad Rafehi, Frank Faltraco, Johannes Matthaei, Thomas Prukop, Ole Jensen

Front Pharmacol· October 2019

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3-(2-Carboxyethyl)indole-2-carboxylic Acid Derivatives: Structural Requirements and Properties of Potent Agonists of the Orphan G Protein-Coupled Receptor GPR17.
Younis Baqi, Thanigaimalai Pillaiyar, Aliaa Abdelrahman, Olesja Kaufmann, Samer Alshaibani, Muhammad Rafehi

J Med Chem· September 2018

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