Publications by authors named "Muhammed A Saad"

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Enhancing mood post-bariatric surgery: Associations of rosuvastatin with vitamin D, oxidative stress, and neurotransmitter-related outcomes in rats.
Sally A Fahim, Muhammad Y Al-Shorbagy, Rabab H Sayed, Albeir Messiha, Muhammed A Saad

Biomed Pharmacother· November 2025

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The GLP-1 agonist semaglutide ameliorates cognitive regression in P301S tauopathy mice model via autophagy/ACE2/SIRT1/FOXO1-Mediated Microglia Polarization.
Norhan N Elbadawy, Muhammed A Saad, Sara Elfarrash, Maha A E Ahmed, Noha F Abdelkader

Eur J Pharmacol· March 2025

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Ascorbic acid Mitigates behavioural disturbances associated with letrozole-induced PCOS via switching-off JAK2/STAT5 and JAK2/ERK1/2 pathways in rat hippocampus.
Muhammed A Saad, Alyasaa A Rastanawi, Ayman E El-Sahar, Alshaymaa A Z El-Bahy

Steroids· January 2025

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Farnesyl pyrophosphate synthase inhibitors with antiosteoporosis efficacy in ovariectomized rats: A mixed binding approach beyond bisphosphonates.
Naglaa F El-Sayed, Marwa El-Hussieny, Shaimaa T Mansour, Marwa A Fouad, Muhammed A Saad

Eur J Med Chem· October 2024

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Natural angiotensin converting enzyme inhibitors: A safeguard against hypertension, respiratory distress syndrome, and chronic kidney diseases.
Aya Khaled, Esraa Ahmed, Mohamed Mamdouh, Hager Saad, Aya Mohamed, Muhammed A Saad

Phytother Res· December 2023

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Roflumilast ameliorates ovariectomy-induced depressive-like behavior in rats via activation of AMPK/mTOR/ULK1-dependent autophagy pathway.
Eman S Zaki, Rabab H Sayed, Muhammed A Saad, Muhammed F El-Yamany

Life Sci· August 2023

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Targeting Autophagy, Apoptosis, and SIRT1/Nrf2 Axis with Topiramate Underlies Its Neuroprotective Effect against Cadmium-Evoked Cognitive Deficits in Rats.
Hany H Arab, Ahmed H Eid, Rania Yahia, Shuruq E Alsufyani, Ahmed M Ashour, Muhammed A Saad

Pharmaceuticals (Basel)· August 2023

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Stimulation of Autophagy by Dapagliflozin Mitigates Cadmium-Induced Testicular Dysfunction in Rats: The Role of AMPK/mTOR and SIRT1/Nrf2/HO-1 Pathways.
Hany H Arab, Ebtehal Mohammad Fikry, Shuruq E Alsufyani, Ahmed M Ashour, Azza A K El-Sheikh, Muhammed A Saad

Pharmaceuticals (Basel)· July 2023

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Dapagliflozin modulates neuronal injury via instigation of LKB1/p-AMPK/GABA R2 signaling pathway and suppression of the inflammatory cascade in an essential tremor rat model.
Ahmed S Kamel, Sama M Farrag, Heba M Mansour, Noha N Nassar, Muhammed A Saad

Expert Opin Ther Targets· June 2023

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A new arsenal of polyphenols to make Parkinson's disease extinct: HPLC-MS/MS profiling, very interesting MAO-B inhibitory activity and antioxidant activity of .
Somaia A Al-Madhagy, Sameh S Gad, Eman S Mostafa, Simone Angeloni, Muhammed A Saad

Nat Prod Res· December 2022

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Dismantling Parkinson's disease with herbs: MAO-B inhibitory activity and quantification of chemical constituents using HPLC-MS/MS of Egyptian local market plants.
Soha Ramadan, Manal M Sabry, Muhammed A Saad, Simone Angeloni, Omar M Sabry

Nat Prod Res· November 2022

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Insights into the role of pERK1/2 signaling in post-cerebral ischemia reperfusion sexual dysfunction in rats.
Reham A Mohammed, Rabab H Sayed, Ayman E El-Sahar, Mohamed A Khattab, Muhammed A Saad

Eur J Pharmacol· October 2022

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A new firewall in the fight against breast cancer: and studies correlating chemistry to apoptotic activity of .
Somaia A Al-Madhagy, Sameh S Gad, Eman S Mostafa, Simone Angeloni, Muhammed A Saad

Nat Prod Res· October 2022

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Nanoformulated Recombinant Human Myelin Basic Protein and Rituximab Modulate Neuronal Perturbations in Experimental Autoimmune Encephalomyelitis in Mice.
Muhammed A Saad, Noha M Eissa, Mohammed A Ahmed, Aliaa N ElMeshad, Götz Laible

Int J Nanomedicine· September 2022

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Inosine attenuates 3-nitropropionic acid-induced Huntington's disease-like symptoms in rats via the activation of the A2AR/BDNF/TrKB/ERK/CREB signaling pathway.
Marwa El-Sayed El-Shamarka, Ayman E El-Sahar, Muhammed A Saad, Naglaa Assaf, Rabab H Sayed

Life Sci· July 2022

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Targeting the TLR4/NF-κΒ Axis and NLRP1/3 Inflammasomes by Rosuvastatin: A Role in Impeding Ovariectomy-Induced Cognitive Decline Neuropathology in Rats.
Muhammed A Saad, Muhammad Y Al-Shorbagy, Hany H Arab

Mol Neurobiol· July 2022

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Dapagliflozin diminishes memory and cognition impairment in Streptozotocin induced diabetes through its effect on Wnt/β-Catenin and CREB pathway.
Hala El-Safty, Ashraf Ismail, Rania M Abdelsalam, Ayman E El-Sahar, Muhammed A Saad

Brain Res Bull· April 2022

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Linagliptin ameliorates acetic acid-induced colitis via modulating AMPK/SIRT1/PGC-1α and JAK2/STAT3 signaling pathway in rats.
Mohamed S El-Ghannam, Muhammed A Saad, Noha N Nassar, Muhammad Farag El-Yamany, Alshaymaa A Z El-Bahy

Toxicol Appl Pharmacol· March 2022

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Nano-ivabradine averts behavioral anomalies in Huntington's disease rat model via modulating Rhes/m-tor pathway.
Muhammed A Saad, Maha A E Ahmed, Norhan N Elbadawy, Noha F Abdelkader

Prog Neuropsychopharmacol Biol Psychiatry· December 2021

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Agomelatine attenuates alcohol craving and withdrawal symptoms by modulating the Notch1 signaling pathway in rats.
Doaa Fathi, Ahmed I Abulsoud, Muhammed A Saad, Noha N Nassar, Mina M Maksimos

Life Sci· November 2021

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Bone marrow mononuclear cells boosts anti-cytogentical aberration effect of N-acetylcysteine and α-lipoic acid in rat's liver and bone marrow: implication of oxidative and inflammatory pathways.
Muhammed F El-Yamany, Eman S Zaki, Sherif A Shaltout, Muhammed A Saad

Toxicol Mech Methods· July 2021

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Peganum harmala enhanced GLP-1 and restored insulin signaling to alleviate AlCl-induced Alzheimer-like pathology model.
Rofida A Saleh, Tarek F Eissa, Dalaal M Abdallah, Muhammed A Saad, Hanan S El-Abhar

Sci Rep· June 2021

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Activation of autophagy and suppression of apoptosis by dapagliflozin attenuates experimental inflammatory bowel disease in rats: Targeting AMPK/mTOR, HMGB1/RAGE and Nrf2/HO-1 pathways.
Hany H Arab, Muhammad Y Al-Shorbagy, Muhammed A Saad

Chem Biol Interact· February 2021

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Liraglutide mends cognitive impairment by averting Notch signaling pathway overexpression in a rat model of polycystic ovary syndrome.
Muhammed A Saad, Muhammad A Eltarzy, Rania M Abdel Salam, Maha A E Ahmed

Life Sci· January 2021

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