Publications by authors named "Murray Clarke"

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Common clonal haematopoiesis driver mutations have disparate effects on macrophage cytokines, clonal expansion and atherogenesis.
Paul R Carter, Lauren Kitt, Amanda Rodgers, Nichola Figg, Ang Zhou, Murray Ch Clarke

JCI Insight· December 2025

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Delineation of a thrombin receptor-stimulated vascular smooth muscle cell transition generating cells in the plaque-stabilizing fibrous cap.
James C K Taylor, Matthew D Worssam, Sebnem Oc, Jordi Lambert, Krishnaa T Mahbubani, Murray C H Clarke

Cardiovasc Res· August 2025

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A CD4 T cell-intrinsic complement C5aR2-prostacyclin-IL-1R2 axis orchestrates Th1 cell contraction.
Jubayer Rahman, Jack A Bibby, Parul Singh, Nicolas S Merle, Erin E West, Murray C H Clarke

Immunity· June 2025

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Human vascular smooth muscle cells utilise chymase for the atypical cleavage and activation of Interleukin-1β.
Alejandra Morales-Maldonado, Melanie Humphry, Nichola Figg, Murray Ch Clarke

Atherosclerosis· March 2024

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Loss of T follicular regulatory cell-derived IL-1R2 augments germinal center reactions via increased IL-1.
Katerina Pyrillou, Melanie Humphry, Lauren A Kitt, Amanda Rodgers, Meritxell Nus, Murray Ch Clarke

JCI Insight· February 2024

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Evidence of a genetic background predisposing to complex regional pain syndrome type 1.
Samiha S Shaikh, Andreas Goebel, Michael C Lee, Michael S Nahorski, Nicholas Shenker, Murray Ch Clarke

J Med Genet· January 2024

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Expansion of fibroblast-like cells may explain the CANTOS meta-analysis findings for patients with clonal hematopoiesis.
Xuan Li, Murray C H Clarke

Nat Cardiovasc Res· January 2024

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PLK1 inhibition dampens NLRP3 inflammasome-elicited response in inflammatory disease models.
Marta Baldrighi, Christian Doreth, Yang Li, Xiaohui Zhao, Emily Warner, Murray Clarke

J Clin Invest· November 2023

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Thrombin-activated interleukin-1α drives atherogenesis, but also promotes vascular smooth muscle cell proliferation and collagen production.
Laura C Burzynski, Alejandra Morales-Maldonado, Amanda Rodgers, Lauren A Kitt, Melanie Humphry, Murray C H Clarke

Cardiovasc Res· October 2023

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The common IL1A single nucleotide polymorphism rs17561 is a hypomorphic mutation that significantly reduces interleukin-1α release from human blood cells.
Kimberley A Wiggins, Katerina Pyrillou, Melanie Humphry, Adam S Butterworth, Murray Ch Clarke

Immunology· March 2023

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Alternative Pathways of IL-1 Activation, and Its Role in Health and Disease.
Katerina Pyrillou, Laura C Burzynski, Murray C H Clarke

Front Immunol· June 2021

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Cell surface IL-1α trafficking is specifically inhibited by interferon-γ, and associates with the membrane via IL-1R2 and GPI anchors.
Julie N E Chan, Melanie Humphry, Lauren Kitt, Dominika Krzyzanska, Kara J Filbey, Murray C H Clarke

Eur J Immunol· November 2020

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Cytokine regulation of apoptosis-induced apoptosis and apoptosis-induced cell proliferation in vascular smooth muscle cells.
Dimitra Aravani, Kirsty Foote, Nichola Figg, Alison Finigan, Anna Uryga, Murray Clarke

Apoptosis· October 2020

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Temporal inhibition of autophagy reveals segmental reversal of ageing with increased cancer risk.
Liam D Cassidy, Andrew R J Young, Christopher N J Young, Elizabeth J Soilleux, Edward Fielder, Murray C H Clarke

Nat Commun· January 2020

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Vascular smooth muscle cells in atherosclerosis.
Gemma L Basatemur, Helle F Jørgensen, Murray C H Clarke, Martin R Bennett, Ziad Mallat

Nat Rev Cardiol· December 2019

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Platelet Isolation and Activation Assays.
Laura C Burzynski, Nicholas Pugh, Murray C H Clarke

Bio Protoc· October 2019

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IL-1α cleavage by inflammatory caspases of the noncanonical inflammasome controls the senescence-associated secretory phenotype.
Kimberley A Wiggins, Aled J Parry, Liam D Cassidy, Melanie Humphry, Steve J Webster, Murray C H Clarke

Aging Cell· June 2019

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Senescence utilises inflammatory caspases to drive SASP.
Kimberley A Wiggins, Murray Ch Clarke

Aging (Albany NY)· June 2019

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Death Is Coming and the Clot Thickens, as Pyroptosis Feeds the Fire.
Laura C Burzynski, Murray C H Clarke

Immunity· June 2019

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The Coagulation and Immune Systems Are Directly Linked through the Activation of Interleukin-1α by Thrombin.
Laura C Burzynski, Melanie Humphry, Katerina Pyrillou, Kimberley A Wiggins, Julie N E Chan, Murray C H Clarke

Immunity· April 2019

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Killing the old: cell senescence in atherosclerosis.
Martin R Bennett, Murray C H Clarke

Nat Rev Cardiol· March 2017

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Basic research: Killing the old: cell senescence in atherosclerosis.
Martin R Bennett, Murray C H Clarke

Nat Rev Cardiol· December 2016

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Vascular Smooth Muscle Cell Senescence Promotes Atherosclerosis and Features of Plaque Vulnerability.
Julie Wang, Anna K Uryga, Johannes Reinhold, Nichola Figg, Lauren Baker, Murray Clarke

Circulation· November 2015

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Interleukin-1α Activity in Necrotic Endothelial Cells Is Controlled by Caspase-1 Cleavage of Interleukin-1 Receptor-2: IMPLICATIONS FOR ALLOGRAFT REJECTION.
Laura C Burzynski, Melanie Humphry, Martin R Bennett, Murray C H Clarke

J Biol Chem· October 2015

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Senescent Vascular Smooth Muscle Cells Drive Inflammation Through an Interleukin-1α-Dependent Senescence-Associated Secretory Phenotype.
Sarah E Gardner, Melanie Humphry, Martin R Bennett, Murray C H Clarke

Arterioscler Thromb Vasc Biol· September 2015

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