Publications by authors named "Nancy Woychik"

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Targeted removal of the 16S rRNA anti-Shine-Dalgarno sequence by a Mycobacterium tuberculosis MazF toxin.
Timothy W Sherrier, Valdir C Barth, Jason M Schifano, Julia R Greendyk, Nancy A Woychik

J Biol Chem· July 2025

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Phosphorylation of VapB antitoxins affects intermolecular interactions to regulate VapC toxin activity in .
Basanti Malakar, Valdir C Barth, Julia Puffal, Nancy A Woychik, Robert N Husson

J Bacteriol· October 2024

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Phosphorylation of VapB antitoxins affects intermolecular interactions to regulate VapC toxin activity in .
Basanti Malakar, Valdir Barth, Julia Puffal, Nancy Woychik, Robert N Husson

bioRxiv· May 2024

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Mycobacterium abscessus VapC5 toxin potentiates evasion of antibiotic killing by ribosome overproduction and activation of multiple resistance pathways.
Eduardo A Troian, Heather M Maldonado, Unnati Chauhan, Valdir C Barth, Nancy A Woychik

Nat Commun· June 2023

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tRNA Inactivating Mycobacterium tuberculosis VapBC Toxin-Antitoxin Systems as Therapeutic Targets.
Unnati Chauhan, Valdir C Barth, Nancy A Woychik

Antimicrob Agents Chemother· May 2022

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VapC4 toxin engages small ORFs to initiate an integrated oxidative and copper stress response.
Valdir C Barth, Unnati Chauhan, Jumei Zeng, Xiaoyang Su, Haiyan Zheng, Nancy A Woychik

Proc Natl Acad Sci U S A· August 2021

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The Sole MazF Toxin Targets tRNA to Impart Highly Selective, Codon-Dependent Proteome Reprogramming.
Valdir Cristovao Barth, Nancy A Woychik

Front Genet· February 2020

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Toxin-mediated ribosome stalling reprograms the Mycobacterium tuberculosis proteome.
Valdir C Barth, Ju-Mei Zeng, Irina O Vvedenskaya, Ming Ouyang, Robert N Husson, Nancy A Woychik

Nat Commun· July 2019

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Accurate target identification for Mycobacterium tuberculosis endoribonuclease toxins requires expression in their native host.
Melvilí Cintrón, Ju-Mei Zeng, Valdir C Barth, Jonathan W Cruz, Robert N Husson, Nancy A Woychik

Sci Rep· April 2019

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Cloaked dagger: tRNA slicing by an unlikely culprit.
Jason M Schifano, Nancy A Woychik

RNA Biol· January 2017

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tRNAs taking charge.
Jonathan W Cruz, Nancy A Woychik

Pathog Dis· March 2016

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tRNA is a new target for cleavage by a MazF toxin.
Jason M Schifano, Jonathan W Cruz, Irina O Vvedenskaya, Regina Edifor, Ming Ouyang, Nancy A Woychik

Nucleic Acids Res· February 2016

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Growth-regulating Mycobacterium tuberculosis VapC-mt4 toxin is an isoacceptor-specific tRNase.
Jonathan W Cruz, Jared D Sharp, Eric D Hoffer, Tatsuya Maehigashi, Irina O Vvedenskaya, Nancy A Woychik

Nat Commun· July 2015

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23S rRNA as an a-Maz-ing new bacterial toxin target.
Jason M Schifano, Nancy A Woychik

RNA Biol· November 2014

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Teaching Fido new ModiFICation tricks.
Jonathan W Cruz, Nancy A Woychik

PLoS Pathog· September 2014

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An RNA-seq method for defining endoribonuclease cleavage specificity identifies dual rRNA substrates for toxin MazF-mt3.
Jason M Schifano, Irina O Vvedenskaya, Jared G Knoblauch, Ming Ouyang, Bryce E Nickels, Nancy A Woychik

Nat Commun· April 2014

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Doc toxin is a kinase that inactivates elongation factor Tu.
Jonathan W Cruz, Francesca P Rothenbacher, Tatsuya Maehigashi, William S Lane, Christine M Dunham, Nancy A Woychik

J Biol Chem· March 2014

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Mycobacterial toxin MazF-mt6 inhibits translation through cleavage of 23S rRNA at the ribosomal A site.
Jason M Schifano, Regina Edifor, Jared D Sharp, Ming Ouyang, Arvind Konkimalla, Nancy A Woychik

Proc Natl Acad Sci U S A· May 2013

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Clostridium difficile MazF toxin exhibits selective, not global, mRNA cleavage.
Francesca P Rothenbacher, Motoo Suzuki, Jennifer M Hurley, Thomas J Montville, Thomas J Kirn, Nancy A Woychik

J Bacteriol· July 2012

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Growth and translation inhibition through sequence-specific RNA binding by Mycobacterium tuberculosis VapC toxin.
Jared D Sharp, Jonathan W Cruz, Sahadevan Raman, Masayori Inouye, Robert N Husson, Nancy A Woychik

J Biol Chem· April 2012

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Bacterial toxin RelE mediates frequent codon-independent mRNA cleavage from the 5' end of coding regions in vivo.
Jennifer M Hurley, Jonathan W Cruz, Ming Ouyang, Nancy A Woychik

J Biol Chem· April 2011

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Noncognate Mycobacterium tuberculosis toxin-antitoxins can physically and functionally interact.
Ling Zhu, Jared D Sharp, Hiroshi Kobayashi, Nancy A Woychik, Masayori Inouye

J Biol Chem· December 2010

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Crystal structures of Phd-Doc, HigA, and YeeU establish multiple evolutionary links between microbial growth-regulating toxin-antitoxin systems.
Mark A Arbing, Samuel K Handelman, Alexandre P Kuzin, Grégory Verdon, Chi Wang, Nancy A Woychik

Structure· August 2010

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Bacterial toxin HigB associates with ribosomes and mediates translation-dependent mRNA cleavage at A-rich sites.
Jennifer M Hurley, Nancy A Woychik

J Biol Chem· July 2009

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Bacterial toxin YafQ is an endoribonuclease that associates with the ribosome and blocks translation elongation through sequence-specific and frame-dependent mRNA cleavage.
Meredith H Prysak, Christopher J Mozdzierz, Angela M Cook, Ling Zhu, Yonglong Zhang, Nancy A Woychik

Mol Microbiol· March 2009

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