Publications by authors named "Nathan A Lack"

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Non-canonical functions of UGT2B17 promote castrate-resistant prostate cancer progression.
Tingting Feng, Ning Xie, Lin Gao, Qiongqiong Jia, Sonia Kung, Nathan A Lack

J Clin Invest· December 2025

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Distinct transcription factor interactions drive HOXB13 activity in different stages of prostate cancer.
Betul Ersoy-Fazlioglu, Shreyas Lingadahalli, Umut Berkay Altintas, Ahmet Cingoz, Emirhan Tekoglu, Nathan A Lack

Proc Natl Acad Sci U S A· December 2025

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Baited SELEX: Drug-Directed Selection of Aptamers to PSMA for Targeting of Prostate Cancer Xenografts in Mice.
Kun Liu, Nicole Robinson, Emirhan Tekoglu, Jerome Lozada, Ivan Pak Lok Yu, Nathan A Lack

J Am Chem Soc· November 2025

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Elucidating molecularly stratified single agent, and combination, therapeutic strategies targeting MCL1 for lethal prostate cancer.
Juan M Jiménez-Vacas, Daniel Westaby, Ines Figueiredo, Alexis De Haven Brandon, Ana Padilha, Nathan A Lack

Nat Commun· October 2025

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Coregulators determine androgen receptor activity in prostate cancer.
Kerim Yavuz, Nathan A Lack

Biosci Rep· August 2025

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Comprehensive functional annotation of ESR1-driven enhancers in breast cancer reveals hierarchical activity independent of genomic and epigenomic contexts.
Yanis Zekri, Sebastian Gregoricchio, Elif Yapıcı, Chia-Chi Flora Huang, Tunç Morova, Nathan A Lack

Genome Res· July 2025

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Chromatin-focused genetic and chemical screens identify BRPF1 as a targetable vulnerability in Taxol-resistant triple-negative breast cancer.
Ozlem Yedier-Bayram, Ahmet Cingöz, Ebru Yilmaz, Ali Cenk Aksu, Beril Esin, Nathan A Lack

Exp Mol Med· June 2025

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A chromatin-focused CRISPR screen identifies USP22 as a barrier to somatic cell reprogramming.
Gülben Gürhan, Kenan Sevinç, Can Aztekin, Mert Gayretli, Alperen Yılmaz, Nathan A Lack

Commun Biol· March 2025

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Identification of selective SWI/SNF dependencies in enzalutamide-resistant prostate cancer.
Bengul Gokbayrak, Umut Berkay Altintas, Shreyas Lingadahalli, Tunc Morova, Chia-Chi Flora Huang, Nathan A Lack

Commun Biol· February 2025

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Inference of transcriptional regulation from STARR-seq data.
Amin Safaeesirat, Hoda Taeb, Emirhan Tekoglu, Tunc Morova, Nathan A Lack

Phys Rev E· February 2025

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Increased nuclear factor I-mediated chromatin access drives transition to androgen receptor splice variant dependence in prostate cancer.
Larysa Poluben, Mannan Nouri, Jiaqian Liang, Shaoyong Chen, Andreas Varkaris, Nathan A Lack

Cell Rep· January 2025

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AR-V7 condensates drive androgen-independent transcription in castration resistant prostate cancer.
Shabnam Massah, Nicholas Pinette, Jane Foo, Sumanjit Datta, Maria Guo, Nathan A Lack

bioRxiv· January 2025

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Decoding the epigenetics and chromatin loop dynamics of androgen receptor-mediated transcription.
Umut Berkay Altıntaş, Ji-Heui Seo, Claudia Giambartolomei, Dogancan Ozturan, Brad J Fortunato, Nathan A Lack

Nat Commun· November 2024

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Genomic and transcriptomic features of androgen receptor signaling inhibitor resistance in metastatic castration-resistant prostate cancer.
Xiaolin Zhu, Tatyanah Farsh, Daniël Vis, Ivan Yu, Haolong Li, Nathan A Lack

J Clin Invest· August 2024

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Increased chromatin accessibility mediated by nuclear factor I drives transition to androgen receptor splice variant dependence in castration-resistant prostate cancer.
Larysa Poluben, Mannan Nouri, Jiaqian Liang, Andreas Varkaris, Betul Ersoy-Fazlioglu, Nathan A Lack

bioRxiv· June 2024

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Estrogen receptor 1 chromatin profiling in human breast tumors reveals high inter-patient heterogeneity with enrichment of risk SNPs and enhancer activity at most-conserved regions.
Stacey E P Joosten, Sebastian Gregoricchio, Suzan Stelloo, Elif Yapıcı, Chia-Chi Flora Huang, Nathan A Lack

Genome Res· May 2024

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5-Fluoro/(trifluoromethoxy)-2-indolinone derivatives with anti-interleukin-1 activity.
Özge Soylu-Eter, Zekiye Şeyma Sevinçli, Betül Ersoy, Bahar Hasanusta, Uğur Gatfar, Nathan A Lack

Arch Pharm (Weinheim)· December 2023

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Epigenetic-focused CRISPR/Cas9 screen identifies (absent, small, or homeotic)2-like protein (ASH2L) as a regulator of glioblastoma cell survival.
Ezgi Ozyerli-Goknar, Ezgi Yagmur Kala, Ali Cenk Aksu, Ipek Bulut, Ahmet Cingöz, Nathan A Lack

Cell Commun Signal· November 2023

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Curcuphenol possesses an unusual histone deacetylase enhancing activity that counters immune escape in metastatic tumours.
Samantha L S Ellis, Sarah Dada, Lilian L Nohara, Iryna Saranchova, Lonna Munro, Nathan A Lack

Front Pharmacol· August 2023

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The "Ins and Outs" of Prostate Specific Membrane Antigen (PSMA) as Specific Target in Prostate Cancer Therapy.
Felipe Eltit, Nicole Robinson, Pak Lok Ivan Yu, Mitali Pandey, Jerome Lozada, Nathan A Lack

Adv Exp Med Biol· April 2023

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Specific cannabinoids revive adaptive immunity by reversing immune evasion mechanisms in metastatic tumours.
Sarah Dada, Samantha L S Ellis, Christi Wood, Lilian L Nohara, Carola Dreier, Nathan A Lack

Front Immunol· March 2023

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Optimized high-throughput screening of non-coding variants identified from genome-wide association studies.
Tunc Morova, Yi Ding, Chia-Chi F Huang, Funda Sar, Tommer Schwarz, Nathan A Lack

Nucleic Acids Res· February 2023

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Dynamic phase separation of the androgen receptor and its coactivators key to regulate gene expression.
Fan Zhang, Maitree Biswas, Shabnam Massah, Joseph Lee, Shreyas Lingadahalli, Nathan A Lack

Nucleic Acids Res· January 2023

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Extensive androgen receptor enhancer heterogeneity in primary prostate cancers underlies transcriptional diversity and metastatic potential.
Jeroen Kneppers, Tesa M Severson, Joseph C Siefert, Pieter Schol, Stacey E P Joosten, Nathan A Lack

Nat Commun· November 2022

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Genetic determinants of chromatin reveal prostate cancer risk mediated by context-dependent gene regulation.
Sylvan C Baca, Cassandra Singler, Soumya Zacharia, Ji-Heui Seo, Tunc Morova, Nathan A Lack

Nat Genet· September 2022

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