Publications by authors named "Nathan D Pfeifer"

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Efficacy and safety of an inhaled pan-Janus kinase inhibitor, nezulcitinib, in hospitalised patients with COVID-19: results from a phase 2 clinical trial.
John Belperio, Tuan Nguyen, David A Lombardi, Maxim Bogus, Valentyn Moskalenko, Nathan D Pfeifer

BMJ Open Respir Res· July 2023

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A randomized, double-blind, placebo-controlled, phase 2b study of the efficacy and safety of velusetrag in subjects with diabetic or idiopathic gastroparesis.
Thomas L Abell, Braden Kuo, Tuba Esfandyari, Nathan D Pfeifer, Maria Grimaldi

Neurogastroenterol Motil· April 2023

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Phase I study in healthy participants to evaluate safety, tolerability, and pharmacokinetics of inhaled nezulcitinib, a potential treatment for COVID-19.
Nathan D Pfeifer, Arthur Lo, David L Bourdet, Kenneth Colley, Dave Singh

Clin Transl Sci· November 2021

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A phase 2 multiple ascending dose study of the inhaled pan-JAK inhibitor nezulcitinib (TD-0903) in severe COVID-19.
Dave Singh, Maxim Bogus, Valentyn Moskalenko, Robert Lord, Edmund J Moran, Nathan D Pfeifer

Eur Respir J· October 2021

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Adalimumab long-term safety: infections, vaccination response and pregnancy outcomes in patients with rheumatoid arthritis.
Gerd R Burmester, Robert Landewé, Mark C Genovese, Alan W Friedman, Nathan D Pfeifer

Ann Rheum Dis· February 2017

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Species differences in hepatobiliary disposition of taurocholic acid in human and rat sandwich-cultured hepatocytes: implications for drug-induced liver injury.
Kyunghee Yang, Nathan D Pfeifer, Kathleen Köck, Kim L R Brouwer

J Pharmacol Exp Ther· May 2015

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Role of hepatic efflux transporters in regulating systemic and hepatocyte exposure to xenobiotics.
Nathan D Pfeifer, Rhiannon N Hardwick, Kim L R Brouwer

Annu Rev Pharmacol Toxicol· September 2014

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An experimental approach to evaluate the impact of impaired transport function on hepatobiliary drug disposition using Mrp2-deficient TR- rat sandwich-cultured hepatocytes in combination with Bcrp knockdown.
Kyunghee Yang, Nathan D Pfeifer, Rhiannon N Hardwick, Wei Yue, Paul W Stewart

Mol Pharm· March 2014

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Hepatic basolateral efflux contributes significantly to rosuvastatin disposition I: characterization of basolateral versus biliary clearance using a novel protocol in sandwich-cultured hepatocytes.
Nathan D Pfeifer, Kyunghee Yang, Kim L R Brouwer

J Pharmacol Exp Ther· December 2013

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Hepatic basolateral efflux contributes significantly to rosuvastatin disposition II: characterization of hepatic elimination by basolateral, biliary, and metabolic clearance pathways in rat isolated perfused liver.
Nathan D Pfeifer, Arlene S Bridges, Brian C Ferslew, Rhiannon N Hardwick, Kim L R Brouwer

J Pharmacol Exp Ther· December 2013

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Determination of intracellular unbound concentrations and subcellular localization of drugs in rat sandwich-cultured hepatocytes compared with liver tissue.
Nathan D Pfeifer, Kevin B Harris, Grace Zhixia Yan, Kim L R Brouwer

Drug Metab Dispos· November 2013

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Development of a multiplex UPLC-MRM MS method for quantification of human membrane transport proteins OATP1B1, OATP1B3 and OATP2B1 in in vitro systems and tissues.
Chengjie Ji, William R Tschantz, Nathan D Pfeifer, Mohammed Ullah, Nalini Sadagopan

Anal Chim Acta· March 2012

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Sandwich-cultured hepatocytes: an in vitro model to evaluate hepatobiliary transporter-based drug interactions and hepatotoxicity.
Brandon Swift, Nathan D Pfeifer, Kim L R Brouwer

Drug Metab Rev· August 2010

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Expression, purification and characterization of the human membrane transporter protein OATP2B1 from Sf9 insect cells.
William R Tschantz, Nathan D Pfeifer, Caryl Lane Meade, Leyu Wang, Anthony Lanzetti

Protein Expr Purif· February 2008

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