Publications by authors named "Navdeep Chandel"

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Pathway coessentiality mapping reveals complex II is required for de novo purine biosynthesis in acute myeloid leukaemia.
Amy E Stewart, Derek K Zachman, Pol Castellano-Escuder, Lois M Kelly, Ben Zolyomi, Navdeep S Chandel

Nat Metab· December 2025

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Influenza A infection accelerates disease-associated microglia formation during physiological aging.
Rogan A Grant, Constance E Runyan, Grace A Minogue, Joshua S Stoolman, Satoshi Watanabe, Navdeep S Chandel

bioRxiv· December 2025

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Mitochondrial activity tunes nociceptor resilience to excitotoxicity.
Lin Yuan, Navdeep S Chandel, David Julius

Cell· November 2025

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Intrinsic MicroRNA-10a Restricts Regulatory T Cell Suppressive Function and Intestinal Repair by Coordinating Transcriptional, Metabolic, and Epithelial Repair Pathways.
Wenjing Yang, Tianming Yu, Hui Yang, Suxia Yao, Ruihua Ma, Navdeep S Chandel

Adv Sci (Weinh)· November 2025

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An orphan no more: SLC25A45 controls mitochondrial import of methylated amino acids.
Zachary L Sebo, Navdeep S Chandel

Mol Cell· November 2025

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SGLT2 inhibition protects kidney function by SAM-dependent epigenetic repression of inflammatory genes under metabolic stress.
Hiroshi Maekawa, Yalu Zhou, Yuki Aoi, Margaret E Fain, Dorian S Kaminski, Navdeep S Chandel

J Clin Invest· October 2025

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Genetic modulation of mitochondrial NAD+ regeneration does not prevent dopaminergic neuron dysfunction caused by mitochondrial complex I impairment.
Karis B D'Alessandro, Enrico Zampese, Jenna L E Blum, Britta Kuusik, Alec Palmiotti, Navdeep S Chandel

Front Cell Dev Biol· October 2025

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Metformin inhibits mitochondrial complex I in intestinal epithelium to promote glycemic control.
Zachary L Sebo, Ram P Chakrabarty, Rogan A Grant, Karis B D'Alessandro, Alec R Koss, Navdeep S Chandel

bioRxiv· October 2025

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NADH dehydrogenase reverses dietary and clock metabolic syndrome.
Chelsea Hepler, Nathan J Waldeck, Benjamin J Weidemann, Biliana Marcheva, You-Jia Chen, Navdeep S Chandel

bioRxiv· October 2025

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Treg activation during allograft tolerance induction requires mitochondrion-induced TGF-β1 in type 1 conventional dendritic cells.
Samantha L Schroth, Lei Zhang, Rebecca Tl Jones, Kristofor Glinton, Nikita L Mani, Navdeep S Chandel

J Clin Invest· September 2025

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Mitochondria transfer.
Navdeep S Chandel, Marni J Falk, Janine H Santos, Jonathan R Brestoff, Ana V Lechuga-Vieco

Nat Metab· September 2025

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Mitochondria dysfunction: cause or consequence of physiologic aging?
G R Scott Budinger, Navdeep S Chandel

Genes Dev· August 2025

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Mitochondrial respiration is necessary for CD8 T cell proliferation and cell fate.
Elizabeth M Steinert, Beatriz Furtado Bruza, Veronika D Danchine, Rogan A Grant, Karthik Vasan, Navdeep S Chandel

Nat Immunol· August 2025

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Mitochondria reactive oxygen species signaling-dependent immune responses in macrophages and T cells.
Samuel E Weinberg, Navdeep S Chandel

Immunity· August 2025

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Mitochondrial molecule has unexpected role in tissue healing.
Ram P Chakrabarty, Navdeep S Chandel

Nature· July 2025

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Impaired mitochondrial metabolism is a critical cancer vulnerability for MYC inhibitors.
William Yang, Qianyu Guo, Songhua Quan, Zachary R Chalmers, J Brandon Parker, Navdeep S Chandel

Sci Adv· July 2025

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CRISPR screen reveals a simultaneous targeted mechanism to reduce cancer cell selenium and increase lipid oxidation to induce ferroptosis.
Sophia M Lamperis, Kaylin M McMahon, Andrea E Calvert, Jonathan S Rink, Karthik Vasan, Navdeep S Chandel

Proc Natl Acad Sci U S A· June 2025

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G1 and G2 ApolipoproteinL1 modulate macrophage inflammation and lipid accumulation through the polyamine pathway.
Esther Liu, Matthew Wright, Andrew O Kearney, Tiffany Caza, Johnson Y Yang, Navdeep S Chandel

bioRxiv· June 2025

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Genetic modulation of mitochondrial NAD+ regeneration does not prevent dopaminergic neuron dysfunction caused by mitochondrial complex I impairment.
Karis B D'Alessandro, Enrico Zampese, Jenna L E Blum, Britta Kuusik, Alec Palmiotti, Navdeep S Chandel

bioRxiv· June 2025

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Immunomodulatory role of the stem cell circadian clock in muscle repair.
Pei Zhu, Eric M Pfrender, Adam W T Steffeck, Colleen R Reczek, Yalu Zhou, Navdeep S Chandel

Sci Adv· March 2025

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Pathway Coessentiality Mapping Reveals Complex II is Required for Purine Biosynthesis in Acute Myeloid Leukemia.
Amy E Stewart, Derek K Zachman, Pol Castellano-Escuder, Lois M Kelly, Ben Zolyomi, Navdeep S Chandel

bioRxiv· March 2025

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A metabolic shift to the serine pathway induced by lipids fosters epigenetic reprogramming in nontransformed breast cells.
Mariana Bustamante Eduardo, Gannon Cottone, Curtis W McCloskey, Shiyu Liu, Flavio R Palma, Navdeep S Chandel

Sci Adv· March 2025

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Mitochondria complex III-generated superoxide is essential for IL-10 secretion in macrophages.
Joshua S Stoolman, Rogan A Grant, Leah K Billingham, Taylor A Poor, Samuel E Weinberg, Navdeep S Chandel

Sci Adv· January 2025

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Tissue-resident skeletal muscle macrophages promote recovery from viral pneumonia-induced sarcopenia in normal aging.
Constance E Runyan, Lucy Luo, Lynn C Welch, Ziyan Lu, Fei Chen, Navdeep S Chandel

bioRxiv· January 2025

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Metabolic tuning facilitates nociceptor resilience to excitotoxicity.
Lin Yuan, Navdeep S Chandel, David Julius

bioRxiv· December 2024

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