Publications by authors named "Ne Guo"

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Thioparib inhibits homologous recombination repair, activates the type I IFN response, and overcomes olaparib resistance.
Li-Min Wang, Pingyuan Wang, Xiao-Min Chen, Hui Yang, Shan-Shan Song, Ne Guo

EMBO Mol Med· March 2023

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Repeated treatments of Capan-1 cells with PARP1 and Chk1 inhibitors promote drug resistance, migration and invasion.
Ne Guo, Meng-Zhu Li, Li-Min Wang, Hua-Dong Chen, Shan-Shan Song

Cancer Biol Ther· December 2022

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Novel mutations in intron 11 and overexpression of COX-2 and BIRC3 mediate cellular resistance to PARP inhibitors.
Hua-Dong Chen, Ne Guo, Shan-Shan Song, Chuan-Huizi Chen, Ze-Hong Miao

Am J Cancer Res· September 2020

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Increased PARP1-DNA binding due to autoPARylation inhibition of PARP1 on DNA rather than PARP1-DNA trapping is correlated with PARP1 inhibitor's cytotoxicity.
Hua-Dong Chen, Chuan-Huizi Chen, Yu-Ting Wang, Ne Guo, Yu-Nan Tian

Int J Cancer· August 2019

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Discovery, mechanism and metabolism studies of 2,3-difluorophenyl-linker-containing PARP1 inhibitors with enhanced in vivo efficacy for cancer therapy.
Wenhua Chen, Ne Guo, Minghui Qi, Haiying Dai, Minghuang Hong, Guobin Ren

Eur J Med Chem· September 2017

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