Publications by authors named "Neal D Mathew"

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UBR-1 enzyme network regulates glutamate homeostasis to affect organismal behavior and developmental viability.
Joseph S Pak, Seamus Morrone, Karla J Opperman, Mukul K Midha, Charu Kapil, Neal D Mathew

bioRxiv· July 2025

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ndufs2 zebrafish have impaired survival, neuromuscular activity, morphology, and one-carbon metabolism treatable with folic acid.
Dana V Mitchell, Donna M Iadarola, Neal D Mathew, Kelsey Keith, Christoph Seiler

bioRxiv· July 2025

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Biased regulation of protein synthesis and hypoxic death by a conditional raptor mutation.
Chun-Ling Sun, Cong Xu, Omar Itani, Elyse L Christensen, Harshitha Vijay, Neal D Mathew

Curr Biol· June 2025

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dldhcri3 zebrafish exhibit altered mitochondrial ultrastructure, morphology, and dysfunction partially rescued by probucol or thiamine.
Manuela Lavorato, Donna Iadarola, Cristina Remes, Prabhjot Kaur, Chynna Broxton, Neal D Mathew

JCI Insight· August 2024

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-Glycosylation of MRS2 balances aerobic and anaerobic energy production by reducing rapid mitochondrial Mg influx in conditions of high glucose or impaired respiratory chain function.
Min Peng, Neal D Mathew, Vernon E Anderson, Marni J Falk, Eiko Nakamaru-Ogiso

bioRxiv· July 2024

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N-acetylcysteine and cysteamine bitartrate prevent azide-induced neuromuscular decompensation by restoring glutathione balance in two novel surf1-/- zebrafish deletion models of Leigh syndrome.
Suraiya Haroon, Heeyong Yoon, Christoph Seiler, Bruce Osei-Frimpong, Jie He, Neal D Mathew

Hum Mol Genet· June 2023

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Dichloroacetate and thiamine improve survival and mitochondrial stress in a C. elegans model of dihydrolipoamide dehydrogenase deficiency.
Chynna N Broxton, Prabhjot Kaur, Manuela Lavorato, Smruthi Ganesh, Rui Xiao, Neal D Mathew

JCI Insight· October 2022

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Dichloroacetate improves mitochondrial function, physiology, and morphology in FBXL4 disease models.
Manuela Lavorato, Eiko Nakamaru-Ogiso, Neal D Mathew, Elizabeth Herman, Nina Shah

JCI Insight· August 2022

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The FusX TALE Base Editor (FusXTBE) for Rapid Mitochondrial DNA Programming of Human Cells and Zebrafish Disease Models .
Ankit Sabharwal, Bibekananda Kar, Santiago Restrepo-Castillo, Shannon R Holmberg, Neal D Mathew

CRISPR J· December 2021

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Combinatorial glucose, nicotinic acid and N-acetylcysteine therapy has synergistic effect in preclinical C. elegans and zebrafish models of mitochondrial complex I disease.
Sujay Guha, Neal D Mathew, Chigoziri Konkwo, Julian Ostrovsky, Young Joon Kwon

Hum Mol Genet· May 2021

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Comparative Analysis of Experimental Methods to Quantify Animal Activity in Caenorhabditis elegans Models of Mitochondrial Disease.
Manuela Lavorato, Neal D Mathew, Nina Shah, Eiko Nakamaru-Ogiso, Marni J Falk

J Vis Exp· April 2021

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Pre-clinical evaluation of cysteamine bitartrate as a therapeutic agent for mitochondrial respiratory chain disease.
Sujay Guha, Chigoziri Konkwo, Manuela Lavorato, Neal D Mathew, Min Peng

Hum Mol Genet· June 2019

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Using C. elegans Forward and Reverse Genetics to Identify New Compounds with Anthelmintic Activity.
Mark D Mathew, Neal D Mathew, Angela Miller, Mike Simpson, Vinci Au

PLoS Negl Trop Dis· October 2016

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Nanoparticle imaging and diagnostic of Caenorhabditis elegans intracellular pH.
Neal D Mathew, Mark D Mathew, Peter P T Surawski

Anal Biochem· April 2014

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Sulfurous gases as biological messengers and toxins: comparative genetics of their metabolism in model organisms.
Neal D Mathew, David I Schlipalius, Paul R Ebert

J Toxicol· August 2012

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WormScan: a technique for high-throughput phenotypic analysis of Caenorhabditis elegans.
Mark D Mathew, Neal D Mathew, Paul R Ebert

PLoS One· August 2012

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