Publications by authors named "Neal Rosen"

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The Polycomb Repressor Complex 1 Drives Double-Negative Prostate Cancer Metastasis by Coordinating Stemness and Immune Suppression.
Wenjing Su, Hyun Ho Han, Yan Wang, Boyu Zhang, Bing Zhou, Neal Rosen

Cancer Cell· November 2025

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Targeting mTORC1 to promote ferroptosis and apoptosis in endometrial cancer with PI3K-Akt-mTOR pathway mutation.
Yingying Hu, Pei Liu, Neal Rosen, Xuejun Jiang

Ferroptosis Oxid Stress· November 2025

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RAF-independent MEK mutations drive refractory histiocytic neoplasms but respond to ERK inhibition.
Eli L Diamond, Jean-Francois Emile, Takeshi Fujino, Julien Haroche, Maxim I Maron, Marc Rosenblum, Neal Rosen

Cancer Cell· October 2025

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Direct Inhibition of RAS Reveals the Features of Oncogenic Signaling Driven by RAS G12 and Q61 Mutations.
Michelangelo Marasco, Dinesh Kumar, Santiago Garcia Borrego, Tessa Seale, Giulia Maddalena, Neal Rosen

Cancer Discov· July 2025

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eIF4A controls translation of estrogen receptor alpha and is a therapeutic target in advanced breast cancer.
Jacob A Boyer, Ezra Y Rosen, Malvika Sharma, Madeline A Dorso, Nicholas Mai, Neal Rosen

Proc Natl Acad Sci U S A· July 2025

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Tumorigenesis Driven by BRAFV600E Requires Secondary Mutations That Overcome Its Feedback Inhibition of RAC1 and Migration.
Sunyana Gadal, Jacob A Boyer, Simon F Roy, Noah A Outmezguine, Malvika Sharma, Neal Rosen

Cancer Res· May 2025

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Diet induced insulin resistance is due to induction of PTEN expression.
Radha Mukherjee, Priya Pancholi, Malvika Sharma, Hilla Solomon, Merna N Timaul, Neal Rosen

bioRxiv· March 2025

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Paired primary-metastasis patient-derived organoids and mouse models identify phenotypic evolution and druggable dependencies of peritoneal metastasis from appendiceal cancer.
Ahmed Mahmoud, Philip H Choi, Christine Sukhwa, Jura Pintar, Henry Walch, Neal Rosen

bioRxiv· February 2025

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Concurrent SOS1 and MEK suppression inhibits signaling and growth of NF1-null melanoma.
Michelangelo Marasco, Dinesh Kumar, Tessa Seale, Santiago Garcia Borrego, Esther Kaplun, Neal Rosen

Cell Rep Med· November 2024

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Intermittent MEK Inhibition with GITR Costimulation Rescues T-cell Function for Increased Efficacy with CTLA-4 Blockade in Solid Tumor Models.
Lauren Dong, Hyejin Choi, Sadna Budhu, Isabell Schulze, Svena Verma, Neal Rosen

Cancer Immunol Res· October 2024

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A Next-Generation BRAF Inhibitor Overcomes Resistance to BRAF Inhibition in Patients with BRAF-Mutant Cancers Using Pharmacokinetics-Informed Dose Escalation.
Rona Yaeger, Meredith A McKean, Rizwan Haq, J Thaddeus Beck, Matthew H Taylor, Neal Rosen

Cancer Discov· September 2024

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Tumor-Agnostic Genomic and Clinical Analysis of BRAF Fusions Identifies Actionable Targets.
Monica F Chen, Soo-Ryum Yang, Jessica J Tao, Antoine Desilets, Eli L Diamond, Ezra Rosen, Neal Rosen

Clin Cancer Res· September 2024

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Combined inhibition of KRAS and mTORC1 kinase is synergistic in non-small cell lung cancer.
Hidenori Kitai, Philip H Choi, Yu C Yang, Jacob A Boyer, Adele Whaley, Neal Rosen

Nat Commun· July 2024

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Diet induced insulin resistance is due to induction of PTEN expression.
Neal Rosen, Radha Mukherjee, Priya Pancholi, Malvika Sharma, Hilla Solomon

Res Sq· June 2024

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eIF4A controls translation of estrogen receptor alpha and is a therapeutic target in advanced breast cancer.
Jacob A Boyer, Malvika Sharma, Madeline A Dorso, Nicholas Mai, Corina Amor, Ezra Y Rosen, Neal Rosen

bioRxiv· May 2024

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Tumorigenesis driven by the BRAF oncoprotein requires secondary mutations that overcome its feedback inhibition of migration and invasion.
Sunyana Gadal, Jacob A Boyer, Simon F Roy, Noah A Outmezguine, Malvika Sharma, Neal Rosen

bioRxiv· April 2024

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BRAF - a tumour-agnostic drug target with lineage-specific dependencies.
Aphrothiti J Hanrahan, Ziyu Chen, Neal Rosen, David B Solit

Nat Rev Clin Oncol· March 2024

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Molecular Characterization of Acquired Resistance to KRASG12C-EGFR Inhibition in Colorectal Cancer.
Rona Yaeger, Riccardo Mezzadra, Jenna Sinopoli, Yu Bian, Michelangelo Marasco, Neal Rosen

Cancer Discov· January 2023

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Impaired Proteolysis of Noncanonical RAS Proteins Drives Clonal Hematopoietic Transformation.
Sisi Chen, Rahul S Vedula, Antonio Cuevas-Navarro, Bin Lu, Simon J Hogg, Neal Rosen

Cancer Discov· October 2022

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ARAF protein kinase activates RAS by antagonizing its binding to RASGAP NF1.
Wenjing Su, Radha Mukherjee, Rona Yaeger, Jieun Son, Jianing Xu, Neal Rosen

Mol Cell· July 2022

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Targeting Oncogenic RAS Protein.
Dan L Longo, Neal Rosen

N Engl J Med· July 2022

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Anatomic position determines oncogenic specificity in melanoma.
Joshua M Weiss, Miranda V Hunter, Nelly M Cruz, Arianna Baggiolini, Mohita Tagore, Neal Rosen

Nature· April 2022

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Phase 1 Clinical Trial of Trametinib and Ponatinib in Patients With NSCLC Harboring Mutations.
Kathryn C Arbour, Eusebio Manchado, Matthew J Bott, Linda Ahn, Yosef Tobi, Neal Rosen

JTO Clin Res Rep· January 2022

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HER2 + breast cancers evade anti-HER2 therapy via a switch in driver pathway.
Alison E Smith, Emanuela Ferraro, Anton Safonov, Cristina Bernado Morales, Enrique J Arenas Lahuerta, Neal Rosen

Nat Commun· November 2021

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Targeted drug delivery strategies for precision medicines.
Mandana T Manzari, Yosi Shamay, Hiroto Kiguchi, Neal Rosen, Maurizio Scaltriti

Nat Rev Mater· April 2021

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