Publications by authors named "Neal Sach"

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Accelerating Medicinal Chemistry: A C(sp)-Rich Fragment Toolbox for Redox-Neutral Cross-Coupling.
Jet Tsien, Áron Péter, Xin Zeng, Shuanghu Wang, Baiyang Jiang, Neal W Sach

Angew Chem Int Ed Engl· December 2025

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Discovery of Atirmociclib (PF-07220060): A Potent and Selective CDK4 Inhibitor.
Gary M Gallego, Cynthia Palmer, Suvi Orr, Louise Bernier, Ping Chen, Sacha Ninkovic, Neal Sach

J Med Chem· December 2025

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Correction to "A Tool for Reaction Monitoring in Real Time, the Development of a 'Walk-Up Automated Reaction Profiling' System".
Muhammad Alimuddin, Louise Bernier, John F Braganza, Michael R Collins, Martha Ornelas, Neal Sach

J Org Chem· December 2025

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Development of a Scalable Synthesis of a HPK1 Inhibitor Featuring a Direct α-Arylation of Boc-Protected -Dimethylamine by Palladium-Mediated Negishi Cross-Coupling.
Dahui Zhou, Matthew Del Bel, Thomas Knauber, Simon Berritt, John Braganza, Neal Sach

J Org Chem· August 2025

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Predictive design of crystallographic chiral separation.
Rokas Elijošius, Emma King-Smith, Felix A Faber, Louise Bernier, Simon Berritt, Neal W Sach

Nat Commun· August 2025

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Silyl Triflate-Promoted Sulfonylations.
Jacob C DeForest, Karen R Winters, Neal W Sach, Louise Bernier, Scott C Sutton

Org Lett· February 2025

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A Tool for Reaction Monitoring in Real Time, the Development of a "Walk-Up Automated Reaction Profiling" System.
Muhammad Alimuddin, Louise Bernier, John F Braganza, Michael R Collins, Martha Ornelas, Neal Sach

J Org Chem· December 2024

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Discovery of PF-07265028, A Selective Small Molecule Inhibitor of Hematopoietic Progenitor Kinase 1 (HPK1) for the Treatment of Cancer.
Rebecca A Gallego, Sujin Cho-Schultz, Matthew Del Bel, Anne-Marie Dechert-Schmitt, Joyann S Donaldson, Neal W Sach

J Med Chem· December 2024

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Discovery of Highly Selective Inhibitors of Microtubule-Associated Serine/Threonine Kinase-like (MASTL).
Rebecca A Gallego, Stephanie Scales, Chad Toledo, Marin Auth, Louise Bernier, Neal Sach

J Med Chem· November 2024

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Probing the chemical 'reactome' with high-throughput experimentation data.
Emma King-Smith, Simon Berritt, Louise Bernier, Xinjun Hou, Jacquelyn L Klug-McLeod, Neal W Sach

Nat Chem· April 2024

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Copper-Catalyzed Synthesis of Masked (Hetero)Aryl Sulfinates.
May R Merino, Xinlan A F Cook, David C Blakemore, Ian B Moses, Neal W Sach

Org Lett· April 2024

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Design and Synthesis of Functionally Active 5-Amino-6-Aryl Pyrrolopyrimidine Inhibitors of Hematopoietic Progenitor Kinase 1.
Rebecca A Gallego, Louise Bernier, Hui Chen, Sujin Cho-Schultz, Loanne Chung, Neal Sach

J Med Chem· April 2023

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Reductant-Free Cross-Electrophile Synthesis of Di(hetero)arylmethanes by Palladium-Catalyzed Desulfinative C-C Coupling.
Janette McKnight, Andre Shavnya, Neal W Sach, David C Blakemore, Ian B Moses

Angew Chem Int Ed Engl· May 2022

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Identification of parallel medicinal chemistry protocols to expand branched amine design space.
Edward L Conn, Matthew A Perry, Kecheng Shi, Guotao Wang, Susan Hoy, Neal W Sach

Org Biomol Chem· May 2022

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Mapping Ambiphile Reactivity Trends in the Anti-(Hetero)annulation of Non-Conjugated Alkenes via Pd /Pd Catalysis.
Hui-Qi Ni, Phillippa Cooper, Shouliang Yang, Fen Wang, Neal Sach

Angew Chem Int Ed Engl· March 2022

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Base-Activated Latent Heteroaromatic Sulfinates as Nucleophilic Coupling Partners in Palladium-Catalyzed Cross-Coupling Reactions.
Xinlan A F Cook, Loïc R E Pantaine, David C Blakemore, Ian B Moses, Neal W Sach

Angew Chem Int Ed Engl· October 2021

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Late-Stage Lead Diversification Coupled with Quantitative Nuclear Magnetic Resonance Spectroscopy to Identify New Structure-Activity Relationship Vectors at Nanomole-Scale Synthesis: Application to Loratadine, a Human Histamine H Receptor Inverse Agonist.
Manjinder S Lall, Asser Bassyouni, James Bradow, Maria Brown, Mark Bundesmann, Neal Sach

J Med Chem· July 2020

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High-Throughput Ligand Screening Enables the Enantioselective Conjugate Borylation of Cyclobutenones to Access Synthetically Versatile Tertiary Cyclobutylboronates.
Helen A Clement, Michele Boghi, Rory M McDonald, Louise Bernier, Jotham W Coe, Neal W Sach

Angew Chem Int Ed Engl· December 2019

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Rhodium(III)-Catalyzed C-H Activation: Ligand-Controlled Regioselective Synthesis of 4-Methyl-Substituted Dihydroisoquinolones.
Joyann S Barber, Stephanie Scales, Michelle Tran-Dubé, Fen Wang, Neal W Sach

Org Lett· July 2019

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Synthesis of Pyridopyrazine-1,6-dione γ-Secretase Modulators via Selective 4-Methylimidazole N-Buchwald Arylation.
Longfei Xie, Christopher W Am Ende, Martin Pettersson, Danica A Rankic, Neal W Sach

J Org Chem· April 2019

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Electrochemically Driven, Ni-Catalyzed Aryl Amination: Scope, Mechanism, and Applications.
Yu Kawamata, Julien C Vantourout, David P Hickey, Peng Bai, Longrui Chen, Neal Sach

J Am Chem Soc· April 2019

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A Parallel Approach to 7-(Hetero)arylpyrazolo[1,5- a]pyrimidin-5-ones.
Daniel C Schmitt, Nootaree Niljianskul, Neal W Sach, John I Trujillo

ACS Comb Sci· May 2018

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Optimization of Orally Bioavailable Enhancer of Zeste Homolog 2 (EZH2) Inhibitors Using Ligand and Property-Based Design Strategies: Identification of Development Candidate (R)-5,8-Dichloro-7-(methoxy(oxetan-3-yl)methyl)-2-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3,4-dihydroisoquinolin-1(2H)-one (PF-06821497).
Pei-Pei Kung, Patrick Bingham, Alexei Brooun, Michael Collins, Ya-Li Deng, Neal Sach

J Med Chem· February 2018

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A platform for automated nanomole-scale reaction screening and micromole-scale synthesis in flow.
Damith Perera, Joseph W Tucker, Shalini Brahmbhatt, Christopher J Helal, Ashley Chong, Neal W Sach

Science· January 2018

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Ru/Ni Dual Catalytic Desulfinative Photoredox C-C Cross-Coupling of Alkyl Sulfinate Salts and Aryl Halides.
Thomas Knauber, Ramalakshmi Chandrasekaran, Joseph W Tucker, Jinshan Michael Chen, Matthew Reese, Neal Sach

Org Lett· December 2017

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