Publications by authors named "Neil Bate"

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Engineered Receptor Capture Combined with Mass Spectrometry Enables High-Throughput Detection and Quantitation of SARS-CoV-2 Spike Protein.
Neil Bate, Dan Lane, Sian E Evans, Farah Salim, Natalie S Allcock

JACS Au· February 2025

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In vitro evolution predicts emerging SARS-CoV-2 mutations with high affinity for ACE2 and cross-species binding.
Neil Bate, Christos G Savva, Peter C E Moody, Edward A Brown, Sian E Evans

PLoS Pathog· July 2022

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Intrinsic differences in the mechanisms of Tie2 binding to angiopoietins exploited by directed evolution to create an Ang2-selective ligand trap.
Neil Bate, James Lodge, Nicholas P J Brindle

J Biol Chem· August 2021

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Sin3A recruits Tet1 to the PAH1 domain via a highly conserved Sin3-Interaction Domain.
Aditya Chandru, Neil Bate, Geerten W Vuister, Shaun M Cowley

Sci Rep· October 2018

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Development of an Orthogonal Tie2 Ligand Resistant to Inhibition by Ang2.
Eyad Issa, Andrew J Moss, Marlies Fischer, Mandeep Kang, Sultan Ahmed, Neil Bate

Mol Pharm· September 2018

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A Novel Mechanism for Calmodulin-Dependent Inactivation of Transient Receptor Potential Vanilloid 6.
Neil Bate, Rachel E Caves, Simon P Skinner, Benjamin T Goult, Jaswir Basran

Biochemistry· May 2018

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The Structural Basis of Calcium-Dependent Inactivation of the Transient Receptor Potential Vanilloid 5 Channel.
Fedir M Bokhovchuk, Neil Bate, Nadezda V Kovalevskaya, Benjamin T Goult, Chris A E M Spronk

Biochemistry· May 2018

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Vinculin controls talin engagement with the actomyosin machinery.
Paul Atherton, Ben Stutchbury, De-Yao Wang, Devina Jethwa, Ricky Tsang, Neil Bate

Nat Commun· December 2015

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Talin determines the nanoscale architecture of focal adhesions.
Jaron Liu, Yilin Wang, Wah Ing Goh, Honzhen Goh, Michelle A Baird, Neil Bate

Proc Natl Acad Sci U S A· September 2015

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Structural analysis of calmodulin binding to ion channels demonstrates the role of its plasticity in regulation.
Nadezda V Kovalevskaya, Michiel van de Waterbeemd, Fedir M Bokhovchuk, Neil Bate, René J M Bindels

Pflugers Arch· November 2013

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Structural studies on full-length talin1 reveal a compact auto-inhibited dimer: implications for talin activation.
Benjamin T Goult, Xiao-Ping Xu, Alexandre R Gingras, Mark Swift, Bipin Patel, Neil Bate

J Struct Biol· October 2013

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RIAM and vinculin binding to talin are mutually exclusive and regulate adhesion assembly and turnover.
Benjamin T Goult, Thomas Zacharchenko, Neil Bate, Ricky Tsang, Fiona Hey

J Biol Chem· March 2013

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Mice carrying a complete deletion of the talin2 coding sequence are viable and fertile.
Emmanuel Debrand, Francesco J Conti, Neil Bate, Lorraine Spence, Daniela Mazzeo

Biochem Biophys Res Commun· September 2012

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Talin contains a C-terminal calpain2 cleavage site important in focal adhesion dynamics.
Neil Bate, Alexandre R Gingras, Alexia Bachir, Rick Horwitz, Feng Ye

PLoS One· August 2012

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Subcellular localization of talin is regulated by inter-domain interactions.
Asoka Banno, Benjamin T Goult, HoSup Lee, Neil Bate, David R Critchley

J Biol Chem· April 2012

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A conserved lipid-binding loop in the kindlin FERM F1 domain is required for kindlin-mediated αIIbβ3 integrin coactivation.
Mohamed Bouaouina, Benjamin T Goult, Clotilde Huet-Calderwood, Neil Bate, Nina N Brahme

J Biol Chem· March 2012

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New isoform-specific monoclonal antibodies reveal different sub-cellular localisations for talin1 and talin2.
Uta Praekelt, Petra M Kopp, Kerstin Rehm, Stefan Linder, Neil Bate

Eur J Cell Biol· March 2012

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Mechanotransduction in vivo by repeated talin stretch-relaxation events depends upon vinculin.
Felix Margadant, Li Li Chew, Xian Hu, Hanry Yu, Neil Bate

PLoS Biol· December 2011

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The Structure of the talin head reveals a novel extended conformation of the FERM domain.
Paul R Elliott, Benjamin T Goult, Petra M Kopp, Neil Bate, J Günter Grossmann

Structure· October 2010

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Studies on the morphology and spreading of human endothelial cells define key inter- and intramolecular interactions for talin1.
Petra M Kopp, Neil Bate, Tania M Hansen, Nicholas P J Brindle, Uta Praekelt

Eur J Cell Biol· September 2010

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Central region of talin has a unique fold that binds vinculin and actin.
Alexandre R Gingras, Neil Bate, Benjamin T Goult, Bipin Patel, Petra M Kopp

J Biol Chem· September 2010

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The domain structure of talin: residues 1815-1973 form a five-helix bundle containing a cryptic vinculin-binding site.
Benjamin T Goult, Alexandre R Gingras, Neil Bate, Igor L Barsukov, David R Critchley

FEBS Lett· June 2010

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Structure of a double ubiquitin-like domain in the talin head: a role in integrin activation.
Benjamin T Goult, Mohamed Bouaouina, Paul R Elliott, Neil Bate, Bipin Patel

EMBO J· March 2010

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The structure of the N-terminus of kindlin-1: a domain important for alphaiibbeta3 integrin activation.
Benjamin T Goult, Mohamed Bouaouina, David S Harburger, Neil Bate, Bipin Patel

J Mol Biol· December 2009

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The structure of an integrin/talin complex reveals the basis of inside-out signal transduction.
Nicholas J Anthis, Kate L Wegener, Feng Ye, Chungho Kim, Benjamin T Goult, Neil Bate

EMBO J· November 2009

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