Publications by authors named "Neil Benson"

Claim this Profile
A
A Quantitative Systems Pharmacology Consortium Approach to Managing Immunogenicity of Therapeutic Proteins.
Andrzej M Kierzek, Timothy P Hickling, Isabel Figueroa, J Cory Kalvass, Marjoleen Nijsen, Neil Benson

CPT Pharmacometrics Syst Pharmacol· November 2019

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
Q
Quantitative Systems Pharmacology and Empirical Models: Friends or Foes?
Neil Benson

CPT Pharmacometrics Syst Pharmacol· March 2019

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
F
First-in-human phase I study of the bromodomain and extraterminal motif inhibitor BAY 1238097: emerging pharmacokinetic/pharmacodynamic relationship and early termination due to unexpected toxicity.
Sophie Postel-Vinay, Karin Herbschleb, Christophe Massard, Victoria Woodcock, Jean-Charles Soria, Neil Benson

Eur J Cancer· March 2019

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
The Role of Quantitative Systems Pharmacology in the Design of First-in-Human Trials.
Piet H van der Graaf, Neil Benson

Clin Pharmacol Ther· November 2018

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
Q
Quantitative Systems Pharmacology Model for Alzheimer Disease Indicates Targeting Sphingolipid Dysregulation as Potential Treatment Option.
Diana Clausznitzer, Cesar Pichardo-Almarza, Ana Lucia Relo, Jeroen van Bergeijk, Elizabeth van der Kam, Neil Benson

CPT Pharmacometrics Syst Pharmacol· November 2018

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
U
Use of mathematics to guide target selection in systems pharmacology; application to receptor tyrosine kinase (RTK) pathways.
Neil Benson, Piet H van der Graaf, Lambertus A Peletier

Eur J Pharm Sci· November 2017

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
Prediction of long-term treatment outcome in HCV following 24 day PEG-IFN alpha-2b therapy using population pharmacokinetic-pharmacodynamic mixture modeling and classification analysis.
Svetlana V Vinogradova, Kirill V Zhudenkov, Neil Benson, Piet H Van Der Graaf, Oleg V Demin

J Theor Biol· October 2015

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
The rise of systems pharmacology in drug discovery and development.
Neil Benson, Piet H van der Graaf

Future Med Chem· August 2015

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
N
Network-based discovery through mechanistic systems biology. Implications for applications--SMEs and drug discovery: where the action is.
Neil Benson

Drug Discov Today Technol· August 2015

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
M
Modeling of celiac disease immune response and the therapeutic effect of potential drugs.
Oleg O Demin, Sergey V Smirnov, Victor V Sokolov, Lourdes Cucurull-Sanchez, Cesar Pichardo-Almarza, Neil Benson

BMC Syst Biol· July 2013

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Systems pharmacology of the nerve growth factor pathway: use of a systems biology model for the identification of key drug targets using sensitivity analysis and the integration of physiology and pharmacology.
Neil Benson, Tomomi Matsuura, Sergey Smirnov, Oleg Demin, Hannah M Jones

Interface Focus· April 2013

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
Cross-membrane signal transduction of receptor tyrosine kinases (RTKs): from systems biology to systems pharmacology.
Neil Benson, Piet H van der Graaf, Lambertus A Peletier

J Math Biol· March 2013

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Systems pharmacology: bridging systems biology and pharmacokinetics-pharmacodynamics (PKPD) in drug discovery and development.
Piet H van der Graaf, Neil Benson

Pharm Res· July 2011

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Design and optimisation of orally active TLR7 agonists for the treatment of hepatitis C virus infection.
Thien-Duc Tran, David C Pryde, Peter Jones, Fiona M Adam, Neil Benson

Bioorg Med Chem Lett· April 2011

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
I
Impact of protein binding on receptor occupancy: a two-compartment model.
Lambertus A Peletier, Neil Benson, Piet H van der Graaf

J Theor Biol· August 2010

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
E
Estimation of binding rate constants using a simultaneous mixed-effects method: application to monoamine transporter reuptake inhibitor reboxetine.
Neil Benson, Nelleke Snelder, Bart Ploeger, Carolyn Napier, Harriet Sale

Br J Pharmacol· May 2010

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
Translational pharmacokinetic-pharmacodynamic modelling; application to cardiovascular safety data for PF-00821385, a novel HIV agent.
Grant Langdon, John D Davis, Lynn M McFadyen, Mark Dewhurst, Neil S Brunton, Neil Benson

Br J Clin Pharmacol· April 2010

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
Pharmacokinetic-pharmacodynamic modeling of alpha interferon response induced by a Toll-like 7 receptor agonist in mice.
Neil Benson, Joost de Jongh, Jonathan D Duckworth, Hannah M Jones, Henry E Pertinez

Antimicrob Agents Chemother· March 2010

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
I
Impact of plasma-protein binding on receptor occupancy: an analytical description.
Lambertus A Peletier, Neil Benson, Piet H van der Graaf

J Theor Biol· January 2009

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
Proximate parameter tuning for biochemical networks with uncertain kinetic parameters.
Stephen J Wilkinson, Neil Benson, Douglas B Kell

Mol Biosyst· January 2008

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
B
Bridging the gap between in silico and cell-based analysis of the nuclear factor-kappaB signaling pathway by in vitro studies of IKK2.
Adaoha E C Ihekwaba, Stephen J Wilkinson, Dominic Waithe, David S Broomhead, Peter Li, Neil Benson

FEBS J· April 2007

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
I
Improving the design and analysis of high-throughput screening technology comparison experiments using statistical modeling.
Philip W Woodward, Christine Williams, Andreas Sewing, Neil Benson

J Biomol Screen· February 2006

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
N
NanoStore: a concept for logistical improvements of compound handling in high-throughput screening.
Neil Benson, Helen F Boyd, Jeremy R Everett, Joachim Fries, Philip Gribbon

J Biomol Screen· September 2005

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Development of a 1-microl scale assay for mitogen-activated kinase kinase 7 using 2-D fluorescence intensity distribution analysis anisotropy.
Penny A Wright, Helen F Boyd, Richard C Bethell, Michael Busch, Phillip Gribbon, Neil Benson

J Biomol Screen· October 2002

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis