Publications by authors named "Neil D Perkins"

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Domain-specific AI segmentation of IMPDH2 rod/ring structures in mouse embryonic stem cells.
Samuel T M Ball, Meagan J Hennessy, Yuhan Tan, Kai F Hoettges, Neil D Perkins

BMC Biol· May 2025

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The NEMO/ATM/IKKα complex: A key player in colorectal cancer progression and treatment.
Neil D Perkins

Sci Signal· March 2025

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c-Rel-dependent Chk2 signaling regulates the DNA damage response limiting hepatocarcinogenesis.
Jack Leslie, Jill E Hunter, Amy Collins, Amelia Rushton, Lauren G Russell, Neil D Perkins

Hepatology· October 2023

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A Cell-Based Optimised Approach for Rapid and Efficient Gene Editing of Human Pluripotent Stem Cells.
Sara Cuevas-Ocaña, Jin Ye Yang, Magomet Aushev, George Schlossmacher, Christine E Bear, Neil D Perkins

Int J Mol Sci· June 2023

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Mutation of the RelA(p65) Thr505 phosphosite disrupts the DNA replication stress response leading to CHK1 inhibitor resistance.
Jill E Hunter, Amy E Campbell, Jacqueline A Butterworth, Helene Sellier, Nicola L Hannaway, Neil D Perkins

Biochem J· October 2022

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Regulation of CHK1 inhibitor resistance by a c-Rel and USP1 dependent pathway.
Jill E Hunter, Amy E Campbell, Nicola L Hannaway, Scott Kerridge, Saimir Luli, Neil D Perkins

Biochem J· October 2022

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Up-regulation of the PI3K/AKT and RHO/RAC/PAK signalling pathways in CHK1 inhibitor resistant Eµ-Myc lymphoma cells.
Jill E Hunter, Amy E Campbell, Scott Kerridge, Callum Fraser, Nicola L Hannaway, Neil D Perkins

Biochem J· October 2022

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Claspin haploinsufficiency leads to defects in fertility, hyperplasia and an increased oncogenic potential.
Suzanne Madgwick, Saimir Luli, Helene Sellier, Jacqueline A Butterworth, Jack Leslie, Neil D Perkins

Biochem J· October 2022

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Alphabetti kinase Spaghetti: the complex roles of IKKα and β in the canonical NF-κB pathway.
Neil D Perkins

Biochem J· June 2022

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Increased migration and motility in XIAP-null cells mediated by the C-RAF protein kinase.
Lauren G Russell, Lydia A K Davis, Jill E Hunter, Neil D Perkins, Niall S Kenneth

Sci Rep· May 2022

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Centrosome dysfunction associated with somatic expression of the synaptonemal complex protein TEX12.
Sumit Sandhu, Ieng F Sou, Jill E Hunter, Lucy Salmon, Caroline L Wilson, Neil D Perkins

Commun Biol· December 2021

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Temporal modulation of the NF-κB RelA network in response to different types of DNA damage.
Amy E Campbell, Catarina Ferraz Franco, Ling-I Su, Emma K Corbin, Simon Perkins, Neil D Perkins

Biochem J· February 2021

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Author Correction: Age-associated mitochondrial DNA mutations cause metabolic remodeling that contributes to accelerated intestinal tumorigenesis.
Anna L M Smith, Julia C Whitehall, Carla Bradshaw, David Gay, Fiona Robertson, Neil D Perkins

Nat Cancer· January 2021

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Age-associated mitochondrial DNA mutations cause metabolic remodelling that contributes to accelerated intestinal tumorigenesis.
Anna Lm Smith, Julia C Whitehall, Carla Bradshaw, David Gay, Fiona Robertson, Neil D Perkins

Nat Cancer· October 2020

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Hypoxia induces rapid, STAT3 and ROS dependent, mitochondrial translocation of RelA(p65) and IκBα.
Iglika G Ivanova, Neil D Perkins

Biosci Rep· September 2019

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Induction of the immunoprotective coat of Yersinia pestis at body temperature is mediated by the Caf1R transcription factor.
Abdulmajeed D Al-Jawdah, Iglika G Ivanova, Helen Waller, Neil D Perkins, Jeremy H Lakey

BMC Microbiol· March 2019

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More than just an IκB kinase: the IKK complex coordinates mRNA stability and transcription.
Neil D Perkins

EMBO J· December 2018

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RRAD, IL4I1, CDKN1A, and SERPINE1 genes are potentially co-regulated by NF-κB and p53 transcription factors in cells exposed to high doses of ionizing radiation.
Katarzyna Szołtysek, Patryk Janus, Gracjana Zając, Tomasz Stokowy, Anna Walaszczyk, Neil D Perkins

BMC Genomics· November 2018

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Pro-inflammatory cytokine and high doses of ionizing radiation have similar effects on the expression of NF-kappaB-dependent genes.
Patryk Janus, Katarzyna Szołtysek, Gracjana Zając, Tomasz Stokowy, Anna Walaszczyk, Neil D Perkins

Cell Signal· June 2018

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NFKB1: a suppressor of inflammation, ageing and cancer.
Tyrell Cartwright, Neil D Perkins, Caroline L Wilson

FEBS J· May 2016

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The clinical development candidate CCT245737 is an orally active CHK1 inhibitor with preclinical activity in RAS mutant NSCLC and Eµ-MYC driven B-cell lymphoma.
Mike I Walton, Paul D Eve, Angela Hayes, Alan T Henley, Melanie R Valenti, Neil D Perkins

Oncotarget· January 2016

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c-Rel and its many roles in cancer: an old story with new twists.
Jill E Hunter, Jack Leslie, Neil D Perkins

Br J Cancer· January 2016

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The importance of the p50 NF-κB subunit.
Neil D Perkins

Cell Cycle· December 2015

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Correction: A238L Inhibits NF-ATc2, NF-κB, and c-Jun Activation through a Novel Mechanism Involving Protein Kinase C-θ-Mediated Up-Regulation of the Amino-Terminal Transactivation Domain of p300.
Aitor G Granja, Neil D Perkins, Yolanda Revilla

J Immunol· February 2015

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Regulation of p53 and Rb links the alternative NF-κB pathway to EZH2 expression and cell senescence.
Alessio Iannetti, Adeline C Ledoux, Susan J Tudhope, Hélène Sellier, Bo Zhao, Neil D Perkins

PLoS Genet· September 2014

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