Publications by authors named "Neil L Spector"

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Visualizing Borrelia burgdorferi Infection Using a Small-Molecule Imaging Probe.
Madeline G Sell, David A Alcorta, Andrew E Padilla, Dakota W Nollner, Nicole R Hasenkampf, Neil L Spector

J Clin Microbiol· June 2021

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Selective ERBB2 and BCL2 Inhibition Is Synergistic for Mitochondrial-Mediated Apoptosis in MDS and AML Cells.
Angel Y F Kam, Sadhna O Piryani, Chang-Lung Lee, David A Rizzieri, Neil L Spector

Mol Cancer Res· May 2021

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Medical oncologists' perspectives of the Veterans Affairs National Precision Oncology Program.
Vishal Vashistha, Pradeep J Poonnen, Jane L Snowdon, Halcyon G Skinner, Victoria McCaffrey, Neil L Spector

PLoS One· September 2020

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Comparison of Annotation Services for Next-Generation Sequencing in a Large-Scale Precision Oncology Program.
Evangelia Katsoulakis, Jill E Duffy, Bradley Hintze, Neil L Spector, Michael J Kelley

JCO Precis Oncol· March 2020

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Genomic Analysis of Metastatic Solid Tumors in Veterans: Findings From the VHA National Precision Oncology Program.
Pradeep J Poonnen, Jill E Duffy, Bradley Hintze, Maulik Shukla, Thomas S Brettin, Neil L Spector

JCO Precis Oncol· August 2019

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Epidermal Growth Factor and Granulocyte Colony Stimulating Factor Signaling Are Synergistic for Hematopoietic Regeneration.
Sadhna O Piryani, Angel Y F Kam, Evelyna G Kliassov, Benny J Chen, Neil L Spector

Stem Cells· February 2018

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X-Ray Psoralen Activated Cancer Therapy (X-PACT).
Mark Oldham, Paul Yoon, Zak Fathi, Wayne F Beyer, Justus Adamson, Neil L Spector

PLoS One· July 2017

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A Fluorescent Hsp90 Probe Demonstrates the Unique Association between Extracellular Hsp90 and Malignancy in Vivo.
Lauren B Crowe, Philip F Hughes, David A Alcorta, Takuya Osada, Aaron P Smith, Neil L Spector

ACS Chem Biol· April 2017

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Lapatinib Plasma and Tumor Concentrations and Effects on HER Receptor Phosphorylation in Tumor.
Neil L Spector, Faith C Robertson, Sarah Bacus, Kimberly Blackwell, Deborah A Smith

PLoS One· June 2016

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CHAMBER: A Regional Performance Improvement CME Initiative for Breast Cancer Health Care Providers.
Linda M Sutton, Joseph Geradts, Erika P Hamilton, Kathleen A Havlin, Gretchen G Kimmick, Neil L Spector

J Natl Compr Canc Netw· August 2015

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Identification of an allosteric small-molecule inhibitor selective for the inducible form of heat shock protein 70.
Matthew K Howe, Khaldon Bodoor, David A Carlson, Philip F Hughes, Yazan Alwarawrah, Neil L Spector

Chem Biol· December 2014

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Photo-activated psoralen binds the ErbB2 catalytic kinase domain, blocking ErbB2 signaling and triggering tumor cell apoptosis.
Wenle Xia, David Gooden, Leihua Liu, Sumin Zhao, Erik J Soderblom, Neil L Spector

PLoS One· October 2014

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An heregulin-EGFR-HER3 autocrine signaling axis can mediate acquired lapatinib resistance in HER2+ breast cancer models.
Wenle Xia, Emanual F Petricoin, Sumin Zhao, Leihua Liu, Takuya Osada, Neil L Spector

Breast Cancer Res· September 2014

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Pertuzumab protects the achilles' heel of trastuzumab--emtansine.
William R Gwin, Neil L Spector

Clin Cancer Res· January 2014

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Optical and radioiodinated tethered Hsp90 inhibitors reveal selective internalization of ectopic Hsp90 in malignant breast tumor cells.
Jared J Barrott, Philip F Hughes, Takuya Osada, Xiao-Yi Yang, Zachary C Hartman, Neil L Spector

Chem Biol· September 2013

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A network of substrates of the E3 ubiquitin ligases MDM2 and HUWE1 control apoptosis independently of p53.
Manabu Kurokawa, Jiyeon Kim, Joseph Geradts, Kenkyo Matsuura, Liu Liu, Neil L Spector

Sci Signal· May 2013

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Amplification and high-level expression of heat shock protein 90 marks aggressive phenotypes of human epidermal growth factor receptor 2 negative breast cancer.
Qing Cheng, Jeffrey T Chang, Joseph Geradts, Leonard M Neckers, Timothy Haystead, Neil L Spector

Breast Cancer Res· April 2012

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Truncated ErbB2 expressed in tumor cell nuclei contributes to acquired therapeutic resistance to ErbB2 kinase inhibitors.
Wenle Xia, Zuguo Liu, Rongrong Zong, Leihua Liu, Sumin Zhao, Neil L Spector

Mol Cancer Ther· August 2011

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Resistance to ErbB2 tyrosine kinase inhibitors in breast cancer is mediated by calcium-dependent activation of RelA.
Wenle Xia, Sarah Bacus, Intisar Husain, Leihua Liu, Sumin Zhao, Neil L Spector

Mol Cancer Ther· February 2010

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Understanding the mechanisms behind trastuzumab therapy for human epidermal growth factor receptor 2-positive breast cancer.
Neil L Spector, Kimberly L Blackwell

J Clin Oncol· December 2009

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Acquired resistance to small molecule ErbB2 tyrosine kinase inhibitors.
Franklin L Chen, Wenle Xia, Neil L Spector

Clin Cancer Res· November 2008

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Phase II study of predictive biomarker profiles for response targeting human epidermal growth factor receptor 2 (HER-2) in advanced inflammatory breast cancer with lapatinib monotherapy.
Stephen Johnston, Maureen Trudeau, Bella Kaufman, Hamouda Boussen, Kimberley Blackwell, Neil L Spector

J Clin Oncol· March 2008

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A reciprocal tensin-3-cten switch mediates EGF-driven mammary cell migration.
Menachem Katz, Ido Amit, Ami Citri, Tal Shay, Silvia Carvalho, Neil L Spector

Nat Cell Biol· August 2007

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Activation of AMP-activated protein kinase by human EGF receptor 2/EGF receptor tyrosine kinase inhibitor protects cardiac cells.
Neil L Spector, Yosef Yarden, Bradley Smith, Ljuba Lyass, Patricia Trusk

Proc Natl Acad Sci U S A· June 2007

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Lapatinib antitumor activity is not dependent upon phosphatase and tensin homologue deleted on chromosome 10 in ErbB2-overexpressing breast cancers.
Wenle Xia, Intisar Husain, Leihua Liu, Sarah Bacus, Shermini Saini, Neil L Spector

Cancer Res· February 2007

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