Publications by authors named "Neil P Blackledge"

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The PNUTS phosphatase complex controls transcription pause release.
Jessica R Kelley, Emilia Dimitrova, Maciej Maciuszek, Hieu T Nguyen, Aleksander T Szczurek, Neil P Blackledge

Mol Cell· December 2024

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Epi-microRNA mediated metabolic reprogramming counteracts hypoxia to preserve affinity maturation.
Rinako Nakagawa, Miriam Llorian, Sunita Varsani-Brown, Probir Chakravarty, Jeannie M Camarillo, Neil P Blackledge

Nat Commun· December 2024

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The Polycomb system sustains promoters in a deep OFF state by limiting pre-initiation complex formation to counteract transcription.
Aleksander T Szczurek, Emilia Dimitrova, Jessica R Kelley, Neil P Blackledge, Robert J Klose

Nat Cell Biol· October 2024

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Epi-microRNA mediated metabolic reprogramming ensures affinity maturation.
Rinako Nakagawa, Miriam Llorian, Sunita Varsani-Brown, Probir Chakravarty, Jeannie M Camarillo, Neil P Blackledge

bioRxiv· October 2023

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A CpG island-encoded mechanism protects genes from premature transcription termination.
Amy L Hughes, Aleksander T Szczurek, Jessica R Kelley, Anna Lastuvkova, Anne H Turberfield, Neil P Blackledge

Nat Commun· February 2023

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The molecular principles of gene regulation by Polycomb repressive complexes.
Neil P Blackledge, Robert J Klose

Nat Rev Mol Cell Biol· December 2021

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Variant PCGF1-PRC1 links PRC2 recruitment with differentiation-associated transcriptional inactivation at target genes.
Hiroki Sugishita, Takashi Kondo, Shinsuke Ito, Manabu Nakayama, Nayuta Yakushiji-Kaminatsui, Neil P Blackledge

Nat Commun· September 2021

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BAP1 constrains pervasive H2AK119ub1 to control the transcriptional potential of the genome.
Nadezda A Fursova, Anne H Turberfield, Neil P Blackledge, Emma L Findlater, Anna Lastuvkova

Genes Dev· May 2021

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Getting under the skin of Polycomb-dependent gene regulation.
Neil P Blackledge, Robert J Klose

Genes Dev· March 2021

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PRC1 Catalytic Activity Is Central to Polycomb System Function.
Neil P Blackledge, Nadezda A Fursova, Jessica R Kelley, Miles K Huseyin, Angelika Feldmann

Mol Cell· February 2020

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Cohesin Disrupts Polycomb-Dependent Chromosome Interactions in Embryonic Stem Cells.
James D P Rhodes, Angelika Feldmann, Benjamín Hernández-Rodríguez, Noelia Díaz, Jill M Brown, Neil P Blackledge

Cell Rep· January 2020

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Synergy between Variant PRC1 Complexes Defines Polycomb-Mediated Gene Repression.
Nadezda A Fursova, Neil P Blackledge, Manabu Nakayama, Shinsuke Ito, Yoko Koseki

Mol Cell· June 2019

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Biochemical Identification of Nonmethylated DNA by BioCAP-Seq.
Hannah K Long, Nathan R Rose, Neil P Blackledge, Robert J Klose

Methods Mol Biol· May 2019

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Polycomb repressive complex 1 shapes the nucleosome landscape but not accessibility at target genes.
Hamish W King, Nadezda A Fursova, Neil P Blackledge, Robert J Klose

Genome Res· October 2018

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The SET1 Complex Selects Actively Transcribed Target Genes via Multivalent Interaction with CpG Island Chromatin.
David A Brown, Vincenzo Di Cerbo, Angelika Feldmann, Jaewoo Ahn, Shinsuke Ito, Neil P Blackledge

Cell Rep· September 2017

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MLL-AF4 Spreading Identifies Binding Sites that Are Distinct from Super-Enhancers and that Govern Sensitivity to DOT1L Inhibition in Leukemia.
Jon Kerry, Laura Godfrey, Emmanouela Repapi, Marta Tapia, Neil P Blackledge

Cell Rep· January 2017

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RYBP stimulates PRC1 to shape chromatin-based communication between Polycomb repressive complexes.
Nathan R Rose, Hamish W King, Neil P Blackledge, Nadezda A Fursova, Katherine Ji Ember

Elife· October 2016

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Targeting Polycomb systems to regulate gene expression: modifications to a complex story.
Neil P Blackledge, Nathan R Rose, Robert J Klose

Nat Rev Mol Cell Biol· November 2015

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Variant PRC1 complex-dependent H2A ubiquitylation drives PRC2 recruitment and polycomb domain formation.
Neil P Blackledge, Anca M Farcas, Takashi Kondo, Hamish W King, Joanna F McGouran

Cell· June 2014

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Targeting polycomb to pericentric heterochromatin in embryonic stem cells reveals a role for H2AK119u1 in PRC2 recruitment.
Sarah Cooper, Martin Dienstbier, Raihann Hassan, Lothar Schermelleh, Jafar Sharif, Neil P Blackledge

Cell Rep· June 2014

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Chromatin sampling--an emerging perspective on targeting polycomb repressor proteins.
Robert J Klose, Sarah Cooper, Anca M Farcas, Neil P Blackledge, Neil Brockdorff

PLoS Genet· March 2014

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CpG island chromatin is shaped by recruitment of ZF-CxxC proteins.
Neil P Blackledge, John P Thomson, Peter J Skene

Cold Spring Harb Perspect Biol· November 2013

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ZF-CxxC domain-containing proteins, CpG islands and the chromatin connection.
Hannah K Long, Neil P Blackledge, Robert J Klose

Biochem Soc Trans· June 2013

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Epigenetic conservation at gene regulatory elements revealed by non-methylated DNA profiling in seven vertebrates.
Hannah K Long, David Sims, Andreas Heger, Neil P Blackledge, Claudia Kutter

Elife· February 2013

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KDM2B links the Polycomb Repressive Complex 1 (PRC1) to recognition of CpG islands.
Anca M Farcas, Neil P Blackledge, Ian Sudbery, Hannah K Long, Joanna F McGouran

Elife· December 2012

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