Publications by authors named "Neil Segil"

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Inducible, virus-free direct lineage reprogramming enhances scalable generation of human inner ear hair cell-like cells.
Robert N Rainey, Sam D Houman, Louise Menendez, Ryan Chang, Litao Tao, Neil Segil

bioRxiv· February 2025

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Long-range enhancers maintain competency for hair cell regeneration in the inner ear.
Tuo Shi, Yeeun Kim, Juan Llamas, Xizi Wang, Peter Fabian, Neil Segil

Proc Natl Acad Sci U S A· December 2024

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DNA methylation in the mouse cochlea promotes maturation of supporting cells and contributes to the failure of hair cell regeneration.
John D Nguyen, Juan Llamas, Tuo Shi, J Gage Crump, Andrew K Groves, Neil Segil

Proc Natl Acad Sci U S A· August 2023

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SoxC transcription factors shape the epigenetic landscape to establish competence for sensory differentiation in the mammalian organ of Corti.
Xizi Wang, Juan Llamas, Talon Trecek, Tuo Shi, Litao Tao, Neil Segil

Proc Natl Acad Sci U S A· August 2023

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STAT3 promotes a youthful epigenetic state in articular chondrocytes.
Arijita Sarkar, Nancy Q Liu, Jenny Magallanes, Jade Tassey, Siyoung Lee, Neil Segil

Aging Cell· February 2023

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Single-cell transcriptomic profiling of the zebrafish inner ear reveals molecularly distinct hair cell and supporting cell subtypes.
Tuo Shi, Marielle O Beaulieu, Lauren M Saunders, Peter Fabian, Cole Trapnell, Neil Segil

Elife· January 2023

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Cellular reprogramming with ATOH1, GFI1, and POU4F3 implicate epigenetic changes and cell-cell signaling as obstacles to hair cell regeneration in mature mammals.
Amrita A Iyer, Ishwar Hosamani, John D Nguyen, Tiantian Cai, Sunita Singh, Neil Segil

Elife· November 2022

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CDK2 regulates aminoglycoside-induced hair cell death through modulating c-Jun activity: Inhibiting CDK2 to preserve hearing.
Litao Tao, Neil Segil

Front Mol Neurosci· October 2022

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GFI1 regulates hair cell differentiation by acting as an off-DNA transcriptional co-activator of ATOH1, and a DNA-binding repressor.
Hsin-I Jen, Sunita Singh, Litao Tao, Helen R Maunsell, Neil Segil

Sci Rep· May 2022

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Enhancer decommissioning imposes an epigenetic barrier to sensory hair cell regeneration.
Litao Tao, Haoze V Yu, Juan Llamas, Talon Trecek, Xizi Wang, Neil Segil

Dev Cell· September 2021

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POU4F3 pioneer activity enables ATOH1 to drive diverse mechanoreceptor differentiation through a feed-forward epigenetic mechanism.
Haoze V Yu, Litao Tao, Juan Llamas, Xizi Wang, John D Nguyen, Neil Segil

Proc Natl Acad Sci U S A· July 2021

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Small-molecule inhibition of Lats kinases may promote Yap-dependent proliferation in postmitotic mammalian tissues.
Nathaniel Kastan, Ksenia Gnedeva, Theresa Alisch, Aleksandra A Petelski, David J Huggins, Neil Segil

Nat Commun· May 2021

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Foxc1 establishes enhancer accessibility for craniofacial cartilage differentiation.
Pengfei Xu, Haoze V Yu, Kuo-Chang Tseng, Mackenzie Flath, Peter Fabian, Neil Segil

Elife· January 2021

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Organ of Corti size is governed by Yap/Tead-mediated progenitor self-renewal.
Ksenia Gnedeva, Xizi Wang, Melissa M McGovern, Matthew Barton, Litao Tao, Neil Segil

Proc Natl Acad Sci U S A· June 2020

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Generation of inner ear hair cells by direct lineage conversion of primary somatic cells.
Louise Menendez, Talon Trecek, Suhasni Gopalakrishnan, Litao Tao, Alexander L Markowitz, Neil Segil

Elife· June 2020

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Transcriptomic and epigenetic regulation of hair cell regeneration in the mouse utricle and its potentiation by Atoh1.
Hsin-I Jen, Matthew C Hill, Litao Tao, Kuanwei Sheng, Wenjian Cao, Neil Segil

Elife· April 2019

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Three-dimensional Organotypic Cultures of Vestibular and Auditory Sensory Organs.
Ksenia Gnedeva, A J Hudspeth, Neil Segil

J Vis Exp· June 2018

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Lunatic fringe-mediated Notch signaling regulates adult hippocampal neural stem cell maintenance.
Fatih Semerci, William Tin-Shing Choi, Aleksandar Bajic, Aarohi Thakkar, Juan Manuel Encinas, Neil Segil

Elife· July 2017

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Requirement for Jagged1-Notch2 signaling in patterning the bones of the mouse and human middle ear.
Camilla S Teng, Hai-Yun Yen, Lindsey Barske, Bea Smith, Juan Llamas, Neil Segil

Sci Rep· May 2017

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Fine-tuning of Notch signaling sets the boundary of the organ of Corti and establishes sensory cell fates.
Martin L Basch, Rogers M Brown, Hsin-I Jen, Fatih Semerci, Frederic Depreux, Neil Segil

Elife· December 2016

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Epigenetic regulation of Atoh1 guides hair cell development in the mammalian cochlea.
Zlatka P Stojanova, Tao Kwan, Neil Segil

Development· May 2016

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Mutations in Cockayne Syndrome-Associated Genes (Csa and Csb) Predispose to Cisplatin-Induced Hearing Loss in Mice.
Robert N Rainey, Sum-Yan Ng, Juan Llamas, Gijsbertus T J van der Horst, Neil Segil

J Neurosci· April 2016

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Selection of cell fate in the organ of Corti involves the integration of Hes/Hey signaling at the Atoh1 promoter.
Yassan Abdolazimi, Zlatka Stojanova, Neil Segil

Development· March 2016

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Epigenetic regulation of Atoh1 guides hair cell development in the mammalian cochlea.
Zlatka P Stojanova, Tao Kwan, Neil Segil

Development· October 2015

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Early transcriptional response to aminoglycoside antibiotic suggests alternate pathways leading to apoptosis in sensory hair cells in the mouse inner ear.
Litao Tao, Neil Segil

Front Cell Neurosci· June 2015

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