Publications by authors named "Neil Shneider"

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TDP-43-dependent mis-splicing of KCNQ2 triggers intrinsic neuronal hyperexcitability in ALS/FTD.
Brian J Joseph, Kelly A Marshall, Peter Harley, Jacob R Mann, Francesco Alessandrini, Neil A Shneider

Nat Neurosci· December 2025

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Multiplex neurodegeneration proteotoxicity platform reveals DNAJB6 promotes non-toxic FUS condensate gelation and inhibits neurotoxicity.
Samuel J Resnick, Seema Qamar, Pushya Krishna, Vladislav Korobeynikov, Hannes Ausserwoger, Neil A Shneider

Nat Commun· November 2025

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KIF5A binds RNA to orchestrate synaptic mRNA localization and stress granules in ALS.
Phuong Le, Neeraj K Lal, Shuhao Xu, Sara Mumford, Megan Huang, Neil A Shneider

bioRxiv· November 2025

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Loss of Nuclear TDP-43 Impairs Lipid Metabolism in Microglia-Like Cells.
Khushbu Kabra, Dallin Dressman, Ryan Talcoff, Maedot Yidenk, Olivia M Rifai, Neil A Shneider

Res Sq· November 2025

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Activation of polo-like kinase 1 correlates with selective motor neuron vulnerability in familial ALS.
Barbara Szewczyk, Vitaly Zimyanin, Julia Japtok, Aaron Held, Arun Pal, Neil A Shneider

Cell Rep· September 2025

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A (P56S) mutation in a Dutch patient with familial motor neuron disease: a case report.
Sean W Willemse, Koen C Demaegd, Ruben P A Van Eijk, Philippe Van Damme, Elizabeth Harrington, Neil A Shneider

Amyotroph Lateral Scler Frontotemporal Degener· September 2025

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Loss of Nuclear TDP-43 Impairs Lipid Metabolism in Microglia-Like Cells.
Khushbu Kabra, Dallin Dressman, Ryan Talcoff, Maedot Yidenk, Olivia M Rifai, Neil A Shneider

bioRxiv· September 2025

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Clinical, neuropathological, and biochemical characterization of ALS in a large CHCHD10 R15L family.
Justin Y Kwan, Christian I Lantz, Vlad A Korobeynikov, Allison Snyder, Xiaoping Huang, Neil A Shneider

medRxiv· September 2025

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Amyloid fibril structures link CHCHD10 and CHCHD2 to neurodegeneration.
Guohua Lv, Nicole M Sayles, Yun Huang, Chiara Mancinelli, Kevin McAvoy, Neil A Shneider

Nat Commun· August 2025

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Single-cell transcriptomic landscape of the neuroimmune compartment in amyotrophic lateral sclerosis brain and spinal cord.
John F Tuddenham, Masashi Fujita, Emily Lee, Nivedita Nimmagadda, Anthony Khairallah, Neil A Shneider

Acta Neuropathol· July 2025

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Antisense oligonucleotide jacifusen for FUS-ALS: an investigator-initiated, multicentre, open-label case series.
Neil A Shneider, Matthew B Harms, Vlad A Korobeynikov, Olivia M Rifai, Benjamin N Hoover

Lancet· June 2025

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Excessive emotional reactivity in a case of behavioral variant frontotemporal dementia with amyotrophic lateral sclerosis.
Megan S Barker, Neil A Shneider, Masood Manoochehri, Edward D Huey, Elizabeth C Lindenberger

Psychiatry Res Case Rep· June 2025

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Clinical Safety and Preliminary Efficacy of Regulatory T Cells for ALS.
Neil A Shneider, Alex V Nesta, Olivia M Rifai, Julia Yasek, Wassim Elyaman

NEJM Evid· May 2025

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A proteogenomic tool uncovers protein markers for human microglial states.
Verena Haage, Alex R Bautista, John Tuddenham, Victoria Marshe, Rebecca Chiu, Neil A Shneider

bioRxiv· April 2025

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A factor-based analysis of individual human microglia uncovers regulators of an Alzheimer-related transcriptional signature.
Victoria S Marshe, John F Tuddenham, Kevin Chen, Rebecca Chiu, Verena C Haage, Neil A Shneider

bioRxiv· March 2025

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Amyotrophic lateral sclerosis caused by FUS mutations: advances with broad implications.
Thomas G Moens, Sandrine Da Cruz, Manuela Neumann, Tatyana A Shelkovnikova, Neil A Shneider

Lancet Neurol· February 2025

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Exploring the role of T cells in Alzheimer's and other neurodegenerative diseases: Emerging therapeutic insights from the T Cells in the Brain symposium.
Wassim Elyaman, Lawrence J Stern, Ning Jiang, Dallin Dressman, Philip Bradley, Neil A Shneider

Alzheimers Dement· February 2025

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SUMO2/3 conjugation of TDP-43 protects against aggregation.
Enza Maria Verde, Francesco Antoniani, Laura Mediani, Valentina Secco, Samuele Crotti, Neil Shneider

Sci Adv· February 2025

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Access for ALL in ALS: A large-scale, inclusive, collaborative consortium to unlock the molecular and genetic mechanisms of amyotrophic lateral sclerosis.
James D Berry, Sabrina Paganoni, Matthew B Harms, Neil Shneider, Jinsy Andrews

Muscle Nerve· December 2024

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A cross-disease resource of living human microglia identifies disease-enriched subsets and tool compounds recapitulating microglial states.
John F Tuddenham, Mariko Taga, Verena Haage, Victoria S Marshe, Tina Roostaei, Neil Shneider

Nat Neurosci· December 2024

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Body mass index is lower in asymptomatic expansion carriers but not in pathogenic variant carriers compared to gene negatives.
Ikjae Lee, Mark A Garret, Joanne Wuu, Elizabeth A Harrington, James D Berry, Neil Shneider

Amyotroph Lateral Scler Frontotemporal Degener· November 2024

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Single-cell transcriptomic landscape of the neuroimmune compartment in amyotrophic lateral sclerosis brain and spinal cord.
John F Tuddenham, Masashi Fujita, Anthony Khairallah, Claire Harbison, Xena E Flowers, Neil Shneider

bioRxiv· November 2024

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Identifying FUS amyotrophic lateral sclerosis disease signatures in patient dermal fibroblasts.
Karl Kumbier, Maike Roth, Zizheng Li, Julia Lazzari-Dean, Christopher Waters, Neil Shneider

Dev Cell· August 2024

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Amyloid fibril structures link CHCHD10 and CHCHD2 to neurodegeneration.
Guohua Lv, Nicole M Sayles, Yun Huang, Chiara D Mancinelli, Kevin McAvoy, Neil A Shneider

bioRxiv· July 2024

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Amygdala TDP-43 pathology is associated with behavioural dysfunction and ferritin accumulation in amyotrophic lateral sclerosis.
Olivia M Rifai, Fergal M Waldron, Judi O'Shaughnessy, Fiona L Read, Martina Gilodi, Neil Shneider

bioRxiv· June 2024

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