Publications by authors named "Nicholas A Di Prospero"

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Review article: The need for more efficient and patient-oriented drug development pathways in NASH-setting the scene for platform trials.
Juan M Pericàs, Nicholas A Di Prospero, Quentin M Anstee, Peter Mesenbrinck, Mette S Kjaer

Aliment Pharmacol Ther· May 2023

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Designing an exploratory phase 2b platform trial in NASH with correlated, co-primary binary endpoints.
Elias Laurin Meyer, Peter Mesenbrink, Nicholas A Di Prospero, Juan M Pericàs, Ekkehard Glimm

PLoS One· March 2023

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Platform trials to overcome major shortcomings of traditional clinical trials in non-alcoholic steatohepatitis? Pros and cons.
Juan M Pericàs, Frank Tacke, Quentin M Anstee, Nicholas A Di Prospero, Mette Skalshøj Kjær

J Hepatol· February 2023

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Efficacy and safety of glucagon-like peptide-1/glucagon receptor co-agonist JNJ-64565111 in individuals with type 2 diabetes mellitus and obesity: A randomized dose-ranging study.
Nicholas A Di Prospero, Jaqueline Yee, Mary E Frustaci, Mahesh N Samtani, Maria Alba

Clin Obes· April 2021

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The Subclinical Cardiomyopathy of Friedreich's Ataxia in a Pediatric Population.
Jonathan F Plehn, Keren Hasbani, Inez Ernst, Kenneth D Horton, Bart E Drinkard, Nicholas A Di Prospero

J Card Fail· October 2018

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Mechanism of Increased LDL (Low-Density Lipoprotein) and Decreased Triglycerides With SGLT2 (Sodium-Glucose Cotransporter 2) Inhibition.
Debapriya Basu, Lesley-Ann Huggins, Diego Scerbo, Joseph Obunike, Adam E Mullick, Nicholas A Di Prospero

Arterioscler Thromb Vasc Biol· September 2018

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Pharmacokinetics and pharmacodynamics of canagliflozin in pediatric patients with type 2 diabetes.
William V Tamborlane, David Polidori, Domenick Argenti, Nicholas A Di Prospero

Pediatr Diabetes· June 2018

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Effect of food on the pharmacokinetics of canagliflozin, a sodium glucose co-transporter 2 inhibitor, and assessment of dose proportionality in healthy participants.
Damayanthi Devineni, Prasarn Manitpisitkul, Joseph Murphy, Hans Stieltjes, Jay Ariyawansa, Nicholas A Di Prospero

Clin Pharmacol Drug Dev· July 2015

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Effects of rifampin, cyclosporine A, and probenecid on the pharmacokinetic profile of canagliflozin, a sodium glucose co-transporter 2 inhibitor, in healthy participants.
Damayanthi Devineni, Nicole Vaccaro, Joe Murphy, Christopher Curtin, Rao N V S Mamidi, Nicholas A Di Prospero

Int J Clin Pharmacol Ther· February 2015

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Evaluation of JNJ-26489112 in patients with photosensitive epilepsy: a placebo-controlled, exploratory study.
Nicholas A Di Prospero, Jay J Gambale, Gahan Pandina, Lisa Ford, Suzette Girgis

Epilepsy Res· May 2014

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Assessing function and endurance in adults with spinal and bulbar muscular atrophy: validity of the adult myopathy assessment tool.
Michael O Harris-Love, Lindsay Fernandez-Rhodes, Galen Joe, Joseph A Shrader, Angela Kokkinis, Nicholas A Di Prospero

Rehabil Res Pract· May 2014

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Rating disease progression of Friedreich's ataxia by the International Cooperative Ataxia Rating Scale: analysis of a 603-patient database.
Günther Metz, Nicholas Coppard, Jonathon M Cooper, Martin B Delatycki, Alexandra Dürr, Nicholas A Di Prospero

Brain· January 2013

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Impaired mitochondrial function in psychiatric disorders.
Husseini Manji, Tadafumi Kato, Nicholas A Di Prospero, Seth Ness, M Flint Beal

Nat Rev Neurosci· April 2012

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Efficacy and safety of dutasteride in patients with spinal and bulbar muscular atrophy: a randomised placebo-controlled trial.
Lindsay E Fernández-Rhodes, Angela D Kokkinis, Michelle J White, Charlotte A Watts, Sungyoung Auh, Nicholas A Di Prospero

Lancet Neurol· February 2011

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Histone deacetylases suppress CGG repeat-induced neurodegeneration via transcriptional silencing in models of fragile X tremor ataxia syndrome.
Peter K Todd, Seok Yoon Oh, Amy Krans, Udai B Pandey, Nicholas A Di Prospero

PLoS Genet· December 2010

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Exercise capacity and idebenone intervention in children and adolescents with Friedreich ataxia.
Bart E Drinkard, Randall E Keyser, Scott M Paul, Ross Arena, Jonathan F Plehn, Nicholas A Di Prospero

Arch Phys Med Rehabil· July 2010

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Altered gene expression and DNA damage in peripheral blood cells from Friedreich's ataxia patients: cellular model of pathology.
Astrid C Haugen, Nicholas A Di Prospero, Joel S Parker, Rick D Fannin, Jeff Chou

PLoS Genet· January 2010

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Clinical features of spinal and bulbar muscular atrophy.
Lindsay E Rhodes, Brandi K Freeman, Sungyoung Auh, Angela D Kokkinis, Alison La Pean, Nicholas A Di Prospero

Brain· December 2009

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Standard and modified statistical MUNE evaluations in spinal-bulbar muscular atrophy.
Tanya J Lehky, Cheun Ju Chen, Nicholas A di Prospero, Lindsay E Rhodes, Kenneth Fischbeck

Muscle Nerve· November 2009

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Clinical experience with high-dose idebenone in Friedreich ataxia.
Jörg B Schulz, Nicholas A Di Prospero, Kenneth Fischbeck

J Neurol· March 2009

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Predictors of progression in patients with Friedreich ataxia.
Alison La Pean, Neal Jeffries, Chelsea Grow, Bernard Ravina, Nicholas A Di Prospero

Mov Disord· October 2008

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Expression of expanded polyglutamine targets profilin for degradation and alters actin dynamics.
Barrington G Burnett, Jaime Andrews, Srikanth Ranganathan, Kenneth H Fischbeck, Nicholas A Di Prospero

Neurobiol Dis· June 2008

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Neurological effects of high-dose idebenone in patients with Friedreich's ataxia: a randomised, placebo-controlled trial.
Nicholas A Di Prospero, Angela Baker, Neal Jeffries, Kenneth H Fischbeck

Lancet Neurol· October 2007

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Safety, tolerability, and pharmacokinetics of high-dose idebenone in patients with Friedreich ataxia.
Nicholas A Di Prospero, Charlotte J Sumner, Scott R Penzak, Bernard Ravina, Kenneth H Fischbeck

Arch Neurol· June 2007

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HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS.
Udai Bhan Pandey, Zhiping Nie, Yakup Batlevi, Brett A McCray, Gillian P Ritson, Nicholas A DiProspero

Nature· June 2007

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