Publications by authors named "Nicholas Achille"

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Inhibition of EYA family tyrosine phosphatase activity reveals a therapeutic vulnerability and enhances Menin and DOT1L inhibitor efficacy in KMT2A-rearranged leukemia.
Lola Badmus, Nicholas J Achille, Shubin Zhang, Xianzhong Ding, Nancy J Zeleznik-Le

Exp Hematol Oncol· October 2025

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The MLLT3 YEATS domain is a dual reader of histone marks (H3K9/18/27ac/cr) and ncRNA (7SK), linking epigenetic and RNA signaling to regulate hematopoiesis.
Adam Boulton, Ashish Kabra, Nicholas Achille, Emmalee R Adelman, Dimitrios G Anastasakis

bioRxiv· September 2025

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BCOR Binding to MLL-AF9 Is Essential for Leukemia via Altered EYA1, SIX, and MYC Activity.
Charles R Schmidt, Nicholas J Achille, Aravinda Kuntimaddi, Adam M Boulton, Benjamin I Leach

Blood Cancer Discov· September 2020

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Association between early promoter-specific DNA methylation changes and outcome in older acute myeloid leukemia patients.
Nicholas J Achille, Megan Othus, Kathleen Phelan, Shubin Zhang, Kathrine Cooper

Leuk Res· March 2016

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Degree of recruitment of DOT1L to MLL-AF9 defines level of H3K79 Di- and tri-methylation on target genes and transformation potential.
Aravinda Kuntimaddi, Nicholas J Achille, Jeremy Thorpe, Alyson A Lokken, Ritambhara Singh

Cell Rep· May 2015

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Importance of a specific amino acid pairing for murine MLL leukemias driven by MLLT1/3 or AFF1/4.
Alyson A Lokken, Nicholas J Achille, Ming-Jin Chang, Jeffrey J Lin, Aravinda Kuntimaddi

Leuk Res· November 2014

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Functional specificity of CpG DNA-binding CXXC domains in mixed lineage leukemia.
Laurie E Risner, Aravinda Kuntimaddi, Alyson A Lokken, Nicholas J Achille, Noah W Birch

J Biol Chem· October 2013

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Histone H3 lysine 79 methyltransferase Dot1 is required for immortalization by MLL oncogenes.
Ming-Jin Chang, Hongyu Wu, Nicholas J Achille, Mary Rose Reisenauer, Chau-Wen Chou

Cancer Res· December 2010

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Moderate ethanol preconditioning of rat brain cultures engenders neuroprotection against dementia-inducing neuroinflammatory proteins: possible signaling mechanisms.
Michael A Collins, Edward J Neafsey, Kewei Wang, Nicholas J Achille, Robert M Mitchell

Mol Neurobiol· June 2010

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Regulation of mir-196b by MLL and its overexpression by MLL fusions contributes to immortalization.
Relja Popovic, Laurie E Riesbeck, Chinavenmeni S Velu, Aditya Chaubey, Jiwang Zhang, Nicholas J Achille

Blood· April 2009

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Binge ethanol-induced neurodegeneration in rat organotypic brain slice cultures: effects of PLA2 inhibitor mepacrine and docosahexaenoic acid (DHA).
James Brown, Nicholas Achille, Edward J Neafsey, Michael A Collins

Neurochem Res· February 2009

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Decreased T-cell proliferation and skewed immune responses in LLC-bearing mice.
Rashid M Rashid, Nicholas J Achille, John M Lee, Deanne M R Lathers, M Rita I Young

J Environ Pathol Toxicol Oncol· September 2005

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Modulation of Th1 and Th2 cytokine profiles and their association with advanced head and neck squamous cell carcinoma.
Anthony Sparano, Deanne M R Lathers, Nicholas Achille, Guy J Petruzzelli, M Rita I Young

Otolaryngol Head Neck Surg· November 2004

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Phase 1B study to improve immune responses in head and neck cancer patients using escalating doses of 25-hydroxyvitamin D3.
Deanne M R Lathers, Joseph I Clark, Nicholas J Achille, M Rita I Young

Cancer Immunol Immunother· May 2004

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Incomplete Th2 skewing of cytokines in plasma of patients with squamous cell carcinoma of the head and neck.
Deanne M R Lathers, Nicholas J Achille, M Rita I Young

Hum Immunol· December 2003

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Dendritic cell development from mobilized peripheral blood CD34+ cells.
Deanne M R Lathers, Nicholas Achille, M Rita I Young

Methods Mol Biol· June 2003

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