Publications by authors named "Nicholas Chim"

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Directed evolution of a TNA polymerase identifies independent paths to fidelity and catalysis.
Mohammad Hajjar, Victoria A Maola, Joy J Lee, Manuel J Holguin, Riley N Quijano, Nicholas Chim

Nat Commun· December 2025

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Crystallographic analysis of engineered polymerases synthesizing phosphonomethylthreosyl nucleic acid.
Mohammad Hajjar, Nicholas Chim, Chao Liu, Piet Herdewijn, John C Chaput

Nucleic Acids Res· September 2022

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Transliteration of synthetic genetic enzymes.
Yajun Wang, Xiaolin Liu, Mouhamad Shehabat, Nicholas Chim, John C Chaput

Nucleic Acids Res· November 2021

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Evolution of Functionally Enhanced α-l-Threofuranosyl Nucleic Acid Aptamers.
Cailen M McCloskey, Qingfeng Li, Eric J Yik, Nicholas Chim, Arlene K Ngor

ACS Synth Biol· November 2021

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Synthesis and Polymerase Recognition of Threose Nucleic Acid Triphosphates Equipped with Diverse Chemical Functionalities.
Qingfeng Li, Victoria A Maola, Nicholas Chim, Javeena Hussain, Adriana Lozoya-Colinas

J Am Chem Soc· October 2021

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Following replicative DNA synthesis by time-resolved X-ray crystallography.
Nicholas Chim, Roman A Meza, Anh M Trinh, Kefan Yang, John C Chaput

Nat Commun· May 2021

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Engineering polymerases for applications in synthetic biology.
Ali Nikoomanzar, Nicholas Chim, Eric J Yik, John C Chaput

Q Rev Biophys· July 2020

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Crystal structures of a natural DNA polymerase that functions as an XNA reverse transcriptase.
Lynnette N Jackson, Nicholas Chim, Changhua Shi, John C Chaput

Nucleic Acids Res· July 2019

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Crystal structures of DNA polymerase I capture novel intermediates in the DNA synthesis pathway.
Nicholas Chim, Lynnette N Jackson, Anh M Trinh, John C Chaput

Elife· October 2018

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Synthesis of 2'-Deoxy-α-l-threofuranosyl Nucleoside Triphosphates.
Saikat Bala, Jen-Yu Liao, Li Zhang, Chantel N Tran, Nicholas Chim

J Org Chem· August 2018

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Structural basis for TNA synthesis by an engineered TNA polymerase.
Nicholas Chim, Changhua Shi, Sujay P Sau, Ali Nikoomanzar, John C Chaput

Nat Commun· November 2017

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Salmonella Mitigates Oxidative Stress and Thrives in the Inflamed Gut by Evading Calprotectin-Mediated Manganese Sequestration.
Vladimir E Diaz-Ochoa, Diana Lam, Carlin S Lee, Suzi Klaus, Judith Behnsen, Nicholas Chim

Cell Host Microbe· June 2016

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The Structure and Interactions of Periplasmic Domains of Crucial MmpL Membrane Proteins from Mycobacterium tuberculosis.
Nicholas Chim, Rodrigo Torres, Yuqi Liu, Joe Capri, Gaëlle Batot

Chem Biol· August 2015

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Insights into redox sensing metalloproteins in Mycobacterium tuberculosis.
Nicholas Chim, Parker M Johnson, Celia W Goulding

J Inorg Biochem· April 2014

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Structural snapshots along the reaction pathway of Yersinia pestis RipA, a putative butyryl-CoA transferase.
Rodrigo Torres, Benson Lan, Yama Latif, Nicholas Chim, Celia W Goulding

Acta Crystallogr D Biol Crystallogr· April 2014

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Heme uptake in bacterial pathogens.
Heidi Contreras, Nicholas Chim, Alfredo Credali, Celia W Goulding

Curr Opin Chem Biol· April 2014

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Structural and biochemical characterization of the essential DsbA-like disulfide bond forming protein from Mycobacterium tuberculosis.
Nicholas Chim, Christine A Harmston, David J Guzman, Celia W Goulding

BMC Struct Biol· October 2013

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Insights on how the Mycobacterium tuberculosis heme uptake pathway can be used as a drug target.
Cedric P Owens, Nicholas Chim, Celia W Goulding

Future Med Chem· August 2013

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Structures of oligomers of a peptide from β-amyloid.
Johnny D Pham, Nicholas Chim, Celia W Goulding, James S Nowick

J Am Chem Soc· August 2013

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The Mycobacterium tuberculosis secreted protein Rv0203 transfers heme to membrane proteins MmpL3 and MmpL11.
Cedric P Owens, Nicholas Chim, Amanda B Graves, Christine A Harmston, Angelina Iniguez

J Biol Chem· July 2013

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Withdrawn.
Nicholas Chim, Cedric P. Owens, Heidi Contreras, Celia W. Goulding

Infect Disord Drug Targets· November 2012

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Biochemical, structural and molecular dynamics analyses of the potential virulence factor RipA from Yersinia pestis.
Rodrigo Torres, Robert V Swift, Nicholas Chim, Nicole Wheatley, Benson Lan

PLoS One· February 2012

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Structural insights into RipC, a putative citrate lyase β subunit from a Yersinia pestis virulence operon.
Rodrigo Torres, Nicholas Chim, Banumathi Sankaran, Céline Pujol, James B Bliska

Acta Crystallogr Sect F Struct Biol Cryst Commun· January 2012

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Structure of H/ACA RNP protein Nhp2p reveals cis/trans isomerization of a conserved proline at the RNA and Nop10 binding interface.
Bon-Kyung Koo, Chin-Ju Park, Cesar F Fernandez, Nicholas Chim, Yi Ding

J Mol Biol· September 2011

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Discovery and characterization of a unique mycobacterial heme acquisition system.
Michael V Tullius, Christine A Harmston, Cedric P Owens, Nicholas Chim, Robert P Morse

Proc Natl Acad Sci U S A· March 2011

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