Publications by authors named "Nicholas D Adams"

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Anti-tumor Activity of the Type I PRMT Inhibitor, GSK3368715, Synergizes with PRMT5 Inhibition through MTAP Loss.
Andrew Fedoriw, Satyajit R Rajapurkar, Shane O'Brien, Sarah V Gerhart, Lorna H Mitchell, Nicholas D Adams

Cancer Cell· July 2019

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Reductive carboxylation supports redox homeostasis during anchorage-independent growth.
Lei Jiang, Alexander A Shestov, Pamela Swain, Chendong Yang, Seth J Parker, Nicholas D Adams

Nature· April 2016

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New IDH1 mutant inhibitors for treatment of acute myeloid leukemia.
Ujunwa C Okoye-Okafor, Boris Bartholdy, Jessy Cartier, Enoch N Gao, Beth Pietrak, Nicholas D Adams

Nat Chem Biol· November 2015

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Discovery of a Potent Class of PI3Kα Inhibitors with Unique Binding Mode via Encoded Library Technology (ELT).
Hongfang Yang, Patricia F Medeiros, Kaushik Raha, Patricia Elkins, Kenneth E Lind, Nicholas D Adams

ACS Med Chem Lett· May 2015

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Mutant IDH1 enhances the production of 2-hydroxyglutarate due to its kinetic mechanism.
Alan R Rendina, Beth Pietrak, Angela Smallwood, Huizhen Zhao, Hongwei Qi, Nicholas D Adams

Biochemistry· July 2013

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Discovery of GSK1070916, a potent and selective inhibitor of Aurora B/C kinase.
Nicholas D Adams, Jerry L Adams, Joelle L Burgess, Amita M Chaudhari, Robert A Copeland

J Med Chem· May 2010

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Discovery of the First Potent and Selective Inhibitor of Centromere-Associated Protein E: GSK923295.
Xiangping Qian, Andrew McDonald, Han-Jie Zhou, Nicholas D Adams, Cynthia A Parrish

ACS Med Chem Lett· April 2010

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Discovery of GSK2126458, a Highly Potent Inhibitor of PI3K and the Mammalian Target of Rapamycin.
Steven D Knight, Nicholas D Adams, Joelle L Burgess, Amita M Chaudhari, Michael G Darcy

ACS Med Chem Lett· April 2010

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Novel ATP-competitive kinesin spindle protein inhibitors.
Cynthia A Parrish, Nicholas D Adams, Kurt R Auger, Joelle L Burgess, Jeffrey D Carson

J Med Chem· October 2007

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Total synthesis of bafilomycin V(1): a methanolysis product of the macrolide bafilomycin C(2).
James A Marshall, Nicholas D Adams

J Org Chem· February 2002

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Addition of Allenylzinc Reagents, Prepared in Situ from Nonracemic Propargylic Mesylates, to Aldehydes. A New Synthesis of Highly Enantioenriched Homopropargylic Alcohols.
James A Marshall, Nicholas D Adams

J Org Chem· July 1999

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